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DDS > 3.6 > Flashcards

3.6 Flashcards

1
Q

____ is the lining of the cheek (between the cheek and gums)

A

buccal

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2
Q

___ is the ventral surface of the tongue and floor of mouth (under the tongue)

A

sublingual

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3
Q

Administering drugs to the oral cavity can give us systemic and local effects. Systemic by absorption through …

A

buccal or SL epithelia

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4
Q

Intermediate properties between intestinal mucosa and epidermis is ….

A

coated with mucous, but a squamous epithelium

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5
Q

Epithelium is the principle barrier for _____ and is highly vascularized (blood supply-good for systemic delivery)

A

drug absorption (go throught many skin cell layers)

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6
Q

Buccal and sublingual membranes (are or are not keratinized)

A

are not keratinized

top of mouth is keratinized

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7
Q

Buccal is (more or less) thick than sublingual

A

more (2-8 times more)

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8
Q

Permeability of sublingual is (higher or lower) than buccal

A

higher

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9
Q

Saliva is critical in that it can dissolve the drug but it could also ____ the drug away.

A

wash

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10
Q

Advantage of sublingual/buccal delivery is…

A
  1. Avoidance of GI acid degradation
  2. Avoid GI enzymatic degradation
  3. Avoid hepatic first pass

(Unless swallowed)

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11
Q

No hepatic first pass- drainage is to the ___vein

A

jugular

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12
Q

Nitroglycerin sublingual is super lipophilic and has a ___ onset of action and high blood levels

A

rapid (1-3 minutes)

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13
Q

(Buccal or SL) delivery can be used for prolonged action can be several hours

A

buccal

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14
Q

Disadvantage of sublingual/buccal is the low _______ for most drugs due to skin-like properties.

A

permeability

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15
Q

Disadvantage of sublingual/buccal is drug can be washed away (saliva) and has unpredictable bioavailability due to …

A

mucosal variations

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16
Q

Sublingual products are designed for rapid drug release over a ____ period of time. As drug is dissolves in sublingual pool of saliva before washed away.

A

short

17
Q

Buccal designed for (faster or slower) drug release over a sustained period of time.

A

slower

due to lower permeability, slower absorption

18
Q

Buccal/SL drug must be bland and non-irritating to avoid stimulating…

A

saliva flow

19
Q

Lightly compressed tablets help facilitate …

A

disintegration

20
Q

Nitroglycerin is adsorbed to ____ to reduce explosive risk and evaporation.

A

lactose

21
Q

Levsin/SL is unusual in that it can be ____

A

chewed or swallowed

22
Q

Abstral (fentanyl) is very lipophilic and has high hepatic and intestinal first pass effect making it a poor candidate for ____ delivery for GI absorption.

A

oral drug

good candidate for oral absorption, i.e. buccal/SL

23
Q

Croscarmellose sodium is a..

A

super disintegrant

24
Q

____ tablets such as Saphris, (similar to ODT) but want it to be absorbed in to the mouth (stay in the mouth) and peak plasma concentration within 0.5 to 1.5 hours.

A

Lyophilized

25
Q

____ tablets (or tablet triturates) are prepared by forcing a moistened blend of drug and excipients followed by forcing wet mass out of mold and allowing to dry. Tend to be softer than compressed tablets.

A

Molded

26
Q

Subsys (____ SL) spray that relieves pain as little as 5 minutes

A

Fentanyl

27
Q

Film-drug is uniformly mixed with fast-dissolving polymer an example drug is ____

A

Suboxone SL film

28
Q

Nicorette (Leo) nicotine has high hepatic first pass and an example of _____

A

chewing gum

29
Q

Nicorette has nicotine where there is resin exchange with saliva cations (weak base/cation in our mouth will knock off the drug off of resin) and _____ is critical

A

chewing

30
Q

_____ dissolves slowly in the mouth, hard tablets, prepared like hard candy

A

lozenges

31
Q

Commit Nicotine is an example lozenges and similar to Nicorette, nicotine is bound to a _____

A

cation exchange resin

32
Q

Lozenge on a stick (called _____) example could be fentanyl citrate- Actiq

A

lollipops

33
Q

____ tablets are designed to slowly disintegrate/dissolve and goal to keep in place. Example drug is Striant (testosterone) and Sitavig acyclovir)

A

Mucoadhesive

34
Q

Mucoadhesive excipients include…

A

cellulose derivatives

35
Q

Sitavig is applied to upper gum for 12-14 hours delivery for …

A

Herpes labialis (local action)

36
Q

Oravig is a buccal tablet used for ___ for local action

A

oropharyngeal candidiasis

37
Q

Orally disintegrating tablets for buccal drug delivery include…

A

Zelapar- parkinson’s disease (buccal- avoid food + water)

Fentora (fentanyl citrate)

38
Q

Use of ____ drug delivery system- involves release of CO2 with pH changes that favor dissolution then absorption

A

Oravescent

(pH decrease- favor ionize form and dissolve, then the pH increases-favor union form and absorbed

39
Q

General guideline for buccal/SL tablets is to avoid….

A

eating, drinking, chewing, smoking, and talking

DDS (29 decks)

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