3.6

Question 1

____ is the lining of the cheek (between the cheek and gums)

Answer 1

buccal

Question 2

___ is the ventral surface of the tongue and floor of mouth (under the tongue)

Answer 2

sublingual

Question 3

Administering drugs to the oral cavity can give us systemic and local effects. Systemic by absorption through …

Answer 3

buccal or SL epithelia

Question 4

Intermediate properties between intestinal mucosa and epidermis is ….

Answer 4

coated with mucous, but a squamous epithelium

Question 5

Epithelium is the principle barrier for _____ and is highly vascularized (blood supply-good for systemic delivery)

Answer 5

drug absorption (go throught many skin cell layers)

Question 6

Buccal and sublingual membranes (are or are not keratinized)

Answer 6

are not keratinized

top of mouth is keratinized

Question 7

Buccal is (more or less) thick than sublingual

Answer 7

more (2-8 times more)

Question 8

Permeability of sublingual is (higher or lower) than buccal

Answer 8

higher

Question 9

Saliva is critical in that it can dissolve the drug but it could also ____ the drug away.

Answer 9

wash

Question 10

Advantage of sublingual/buccal delivery is…

Answer 10

1. Avoidance of GI acid degradation
2. Avoid GI enzymatic degradation
3. Avoid hepatic first pass

(Unless swallowed)

Question 11

No hepatic first pass- drainage is to the ___vein

Answer 11

jugular

Question 12

Nitroglycerin sublingual is super lipophilic and has a ___ onset of action and high blood levels

Answer 12

rapid (1-3 minutes)

Question 13

(Buccal or SL) delivery can be used for prolonged action can be several hours

Answer 13

buccal

Question 14

Disadvantage of sublingual/buccal is the low _______ for most drugs due to skin-like properties.

Answer 14

permeability

Question 15

Disadvantage of sublingual/buccal is drug can be washed away (saliva) and has unpredictable bioavailability due to …

Answer 15

mucosal variations

Question 16

Sublingual products are designed for rapid drug release over a ____ period of time. As drug is dissolves in sublingual pool of saliva before washed away.

Answer 16

short

Question 17

Buccal designed for (faster or slower) drug release over a sustained period of time.

Answer 17

slower

due to lower permeability, slower absorption

Question 18

Buccal/SL drug must be bland and non-irritating to avoid stimulating…

Answer 18

saliva flow

Question 19

Lightly compressed tablets help facilitate …

Answer 19

disintegration

Question 20

Nitroglycerin is adsorbed to ____ to reduce explosive risk and evaporation.

Answer 20

lactose

Question 21

Levsin/SL is unusual in that it can be ____

Answer 21

chewed or swallowed

Question 22

Abstral (fentanyl) is very lipophilic and has high hepatic and intestinal first pass effect making it a poor candidate for ____ delivery for GI absorption.

Answer 22

oral drug

good candidate for oral absorption, i.e. buccal/SL

Question 23

Croscarmellose sodium is a..

Answer 23

super disintegrant

Question 24

____ tablets such as Saphris, (similar to ODT) but want it to be absorbed in to the mouth (stay in the mouth) and peak plasma concentration within 0.5 to 1.5 hours.

Answer 24

Lyophilized

Question 25

____ tablets (or tablet triturates) are prepared by forcing a moistened blend of drug and excipients followed by forcing wet mass out of mold and allowing to dry. Tend to be softer than compressed tablets.

Answer 25

Molded

Question 26

Subsys (____ SL) spray that relieves pain as little as 5 minutes

Answer 26

Fentanyl

Question 27

Film-drug is uniformly mixed with fast-dissolving polymer an example drug is ____

Answer 27

Suboxone SL film

Question 28

Nicorette (Leo) nicotine has high hepatic first pass and an example of _____

Answer 28

chewing gum

Question 29

Nicorette has nicotine where there is resin exchange with saliva cations (weak base/cation in our mouth will knock off the drug off of resin) and _____ is critical

Answer 29

chewing

Question 30

_____ dissolves slowly in the mouth, hard tablets, prepared like hard candy

Answer 30

lozenges

Question 31

Commit Nicotine is an example lozenges and similar to Nicorette, nicotine is bound to a _____

Answer 31

cation exchange resin

Question 32

Lozenge on a stick (called _____) example could be fentanyl citrate- Actiq

Answer 32

lollipops

Question 33

____ tablets are designed to slowly disintegrate/dissolve and goal to keep in place. Example drug is Striant (testosterone) and Sitavig acyclovir)

Answer 33

Mucoadhesive

Question 34

Mucoadhesive excipients include...

Answer 34

cellulose derivatives

Question 35

Sitavig is applied to upper gum for 12-14 hours delivery for ...

Answer 35

Herpes labialis (local action)

Question 36

Oravig is a buccal tablet used for ___ for local action

Answer 36

oropharyngeal candidiasis

Question 37

Orally disintegrating tablets for buccal drug delivery include...

Answer 37

Zelapar- parkinson's disease (buccal- avoid food + water) Fentora (fentanyl citrate)

Question 38

Use of ____ drug delivery system- involves release of CO2 with pH changes that favor dissolution then absorption

Answer 38

Oravescent (pH decrease- favor ionize form and dissolve, then the pH increases-favor union form and absorbed

Question 39

General guideline for buccal/SL tablets is to avoid....

Answer 39

eating, drinking, chewing, smoking, and talking