4.11 Advance (12)/Transdermal

Question 1

Some limitations of transdermal drug delivery is that the drug should be ____, ____, and ____

Answer 1

small, lipophilic, and potent

Question 2

_______ - such as enthanol and propylene glycol can increase S.C. permeation by altering the lipids or keratin. This is added in transdermal drug delivery.

Answer 2

Penetration enhancers

Question 3

Follow manufacturers’ recommendation to place patches is important for reducing the risk of loss of drug due to the difference in S.C. thickness and different number of _____ that allow bypass of S.C.

Answer 3

appendages

Question 4

Difference patch ____ determines the amount of drug released over time.

Answer 4

Size (surface area)

Question 5

Application time for transdermal patches of about 7-10 days, because they are ______

Answer 5

occlusive

Question 6

Prolong application time of transdermal patches may lead to _______ + _______ to the skin due to water and warmth of the applicated patch.

Answer 6

maceration and microbial growth

Question 7

Prolonged application time of transdermal patches can increase skin hydration, and occlusion can (increase or decrease) drug permeability.

Answer 7

increase

Question 8

The _____ is the rate-limiting barrier for drug transport

Answer 8

skin

Question 9

Fever and directly applying heat on patches can (increase or decrease) drug release and absorption.

Answer 9

increase

but in some cases can lead to dangerously high levels- Heat-induced Increase

Question 10

Components of transdermal patches comes in three layers: The _____ outer layer, drug/polymer in the middle, and the band-aid-like (release liner)

Answer 10

occlusive

Question 11

______ is an example of a Adhesive Matrix system where the application time is 72 hours and beware of applying heat as it may increase drug absorption where this drug is already potent and increasing absorption is dangerous.

Answer 11

Duragesic (Fentanyl)

Question 12

The adhesive is a matrix system with drug uniformly mixed in. Some includes…

Answer 12

Duragesic
Daytrana
Xulane
Lidoderm

Question 13

An uncommon theme of patch transdermal delivery where this drug, ____, can be cut to size to apply on the area being treated only (local action only)

Answer 13

Lidoderm

Question 14

_______ type of transdermal system where the drug is formulated as a saturated solution (reservior) and teh polymer membrane controls the release and control the entry of drug into the circulation.

Answer 14

Membrane-Controlled (Reservoir)

e.g. androderm

Question 15

Membrane-Controlled transdermal system is a _____ order release and if contents of patch leaks then you lose control of drug release and may lead to drug toxicity.

Answer 15

zero

Question 16

_______ a transdermal combination system in which the rate-controlling membrane gives zero-order release to a matrix system. The drug in the adhesive gives a “bursting effect” (through appendages) or saturates the skin binding sites.

Answer 16

Membrane-Matrix Hybrid

Question 17

Catapres and ______ are examples of Membrane-Matrix Hybrid. The ____ is a drug where you apply it behind the ear because the S.C. is thinner with more shunts (appendages) and takes 4 hours for therapeutic affect to occur.

Answer 17

TransdermScop