nutrition: chapter 20 Flashcards
glucose
primary source of energy for the body
insulin
- produced by beta cells of the pancreas
- needed for glucose transport into cells
diabetes
- metabolic diseases characterized by hyperglycemia
people with diabetes either:
- produce very little to no insulin (insulin deficiency)
- ineffectively use insulin (insulin resistance)
- produce inadequate insulin amount (insulin insufficiency)
hyperglycemia
elevated blood sugar level
classifications
- type 1 diabetes
- type 2 diabetes
- gestational diabetes
- other types
- impaired glucose tolerance
symptoms
- polydipsia
- polyuria
- polyphagia
- unintentional weight loss (type 1)
- blurred vision, fatigue, dehydration, skin irritation or infection, general weakness, loss of strength
lab tests will show
- hyperglycemia
- abnormal glucose tolerance tests (done in pregnancy)
- elevated glycosylated hemoglobin A1c (3 month avg.)
- glucosuria
- proteinuria
- microalbuminuria
diabetic ketoacidosis (DKA)
stages of glucose metabolism
- initial interchange with glycogen (glycogenolysis) and reduction to a smaller central compound (glycolysis pathway)
- joining with the other two energy-yielding nutrients, fat and protein (pyruvate link)
- final common energy production (citric acid cycle and electron transport chain)
exogenous
originating from outside the body
sources of blood glucose
- dietary intake
- glycogen from liver and muscles
uses of blood glucose
- for immediate energy needs: glycolysis
- change to glycogen for storage: glycogenesis
- convert to fat for longer-term storage: lipogenesis
glucagon
- opposes insulin
- responds to hypoglycemia
- alpha cells
somatostatin
- acts as a referee for insulin and glucagon
- delta cells
abnormal metabolism in diabetes (glucose)
- cells are starved for glucose
- glucose concentrations increase in the blood
- hyperglycemia results
abnormal metabolism in diabetes (fat)
- lipolysis in the adipose tissue increases
- fatty acids are released in the blood
- elevated triglyceride levels result
- ketogenesis ensues in the liver
- ketones accumulate in the body
- diabetic ketoacidosis results
abnormal metabolism in diabetes (protein)
- protein tissues are broken down
- weight loss, muscle weakness, and urinary nitrogen loss result
long term complications
- retinopathy (eye damage)
- nephropathy (kidney damage)
- neuropathy (nerve damage)
- heart disease
- dyslipidemia
- hypertension
postprandial
after eating; normally 1-2 hours after a meal
Cushing’s syndrome
glucagonoma
- rare neuroendocrine tumor
- found in alpha cells of pancreas
- leads to overproduction of glucagon
- may cause diabetes, weight loss, high glucagon levels, and hypoaminoacidemia
pheochromocytoma
- tumor of the adrenal medulla or the sympathetic nervous system
- affected cells secrete excess epinephrine or norepinephrine
- causes headache, hypertension, and nausea
hypoglycemia
low blood glucose level
GLUT4
insulin-regulated protein that is responsible for glucose transport into cells