Non-neoplastic WBC disorders Flashcards
an increase in the total number of WBCs per liter of blood is called what?
Leukocytosis
Where are granulocytes produced and stored?
Bone marrow
A patient with leukocytosis will have an increase production of WBCs in the bone marrow because of what three things?
1) Inflammation
2) chronic infection
3) myelo-proliferative disorders ( chronic myeloid leukemia)
3 patients comes to a clinic. patient 1 has an acute bacterial infection, patient 2 is suffering from burns and patient 3 is needing a refill on her corticosteroids. When looking at all three patients white blood cell differential you as the doctor will see an increase in which type of white blood cell?
Neutrophils
Remember what can cause Neutrophilia
Patient with severe sepsis and inflammation comes to the clinic. What kind of changes in the neutrophils will you see as a result of those two conditions?
Morphological changes in neutrophils
Dohle bodies, Toxic Granules & cytoplasmic vacuoles
Neutrophils with a coarser and darker than normal granules will be called what?
a) Toxic Granules
b) Dohle bodies
c) cytoplasmic vacuoles
A) Toxic Granules
The Neutrophils that have dilated RERs that makes them have a dull gray patch would be called:
Dohle bodies
A patient comes to your clinic with a fever, and chronic whooping cough. You order a CBC and a Leukocyte alkaline phosphatase test . The results of the test come back and you see an increase in leukocytes and her LAP test score is High. The most likely diagnosis would be:
Leukemoid reaction
A low Leukocyte Alkaline Phosphatase test will be diagnosed as:
Chronic Myeloid Leukemia
A patient was diagnosed with Hodgkins Lymphoma. In this patient Mast cells/ basophils will release a chemotactic factor that will express an increase in the same kind of WBC that one will see in allergic reactions. What WBC will be increased?
Eosinophils ( eosonophilia)
A patient with TB or bacterial endocarditis will have an increase in what kind of WBCs?
Monocytes ( monocytosis)
A patient with ulcerative colitis ( chronic inflammation) will have an increase in what kind of WBCs?
Monocytes ( monocytosis)
A 18 year old patient is suffering from a fever, sore throat, posterior cervical lymphadenopathy and after inspection you see a grayish/white membrane on his tonsils along with hepato-splenomegaly. He is most likely suffering from what?
Infectious Mononucleosis
After looking a peripheral blood smear of a patient, you see atypical lymphocytes that have a ballerina skirt appearance. what would this be called?
Lymphocytosis
A patient presents to your clinic with an enlarged lymph node that is tender to touch, it is reddish. What kind of Lymphadenopathy will this patient most likely have?
Acute non specific lymphadenitis
What are the three lymphadenopathies that will NOT be tender to touch?
Chronic Lymphadenitis
Metatastic Tumor
Lymphoma/Leukemia
Follicular Hyperplasia will activate which cells?
B cells
remember it is associated with early HIV and rheumatoid arthritis
In Para-cortical hyperplasia which cells will be activated?
T cells
remember its associated with viral infections or Infectious Mononucleosis
A decrease in circulating WBCs is called what?
Leucopenia
Neutropenia can arise from what?
inadequate or ineffective erythropoesis which leades to Hypercellular Bone Marrow
A patient with lymphopenia you would first suspect what?
Hiv/AIDS
A person with overwhleming bacterial, fungal infections will increase the peripheral utilization of neutrophils which will lead to what?
Neutropenia
What kind of Anti-cancer drugs will lead to neutropenia?
Alkylating agents/ anti metabolites
The most common cause of agranulocytosis is what?
Drug toxicity
