antigens and antibodies

Question 1

Based on its complexity what is the most antigenic molecule in our body?

Answer 1

Proteins

Question 2

What are the four factors that contribute to the immunogenicity of an antigen?

Answer 2

Dose
Route
Host factors
Adjuvant effects

Question 3

Adjuvant effects is what?

Answer 3

When the immune response to an antigen is enhanced by the presence of a chemical substance

Question 4

Haptens are what?

Answer 4

Small molecules that are not immunogenic on their own. They must be conjugated to a carrier to be immunogenic

Question 5

What needs MHC to bind to it?

Answer 5

T cells ( remember T cells can only recognize peptide antigens which are loaded on the MHC that are presented to the T cell)

Question 6

MHC 1 is for what?

Answer 6

Endogenously derived peptides ( VIRUS)

Question 7

MHC 2 is for what

Answer 7

exogenously derived peptides ( BACTERIA)

Question 8

The portion of the antigen that binds to the antigen recognition molecule such as on a antibody or T cell is referred to as what?

Answer 8

Epitope

Question 9

Epitopes that are on the same amino acid chain are called what?

Answer 9

Linear epitopes

Question 10

When epitopes are formed by a 3D confirmation are called what?

Answer 10

conformational epitope

Question 11

If an antigen has 4 epitopes. what is its valence?

Answer 11

4 ( remember the total valence is the total number of epitopes)

Question 12

What type of epitope is the first to be lost when an antigen is degraded?

Answer 12

conformational epitopes

Question 13

What are the four faces of the Antigen Elimination Curve

Answer 13

1) Equilibrium phase
2) catabolic decay phase
3) immune elimination phase
4) Detectable antigen specific antibody

Question 14

Which phase occures within a day or two of the ag entering the body?

Answer 14

equilibrium phase

Question 15

at what stage does the adaptive immune system begins to respond by the production of antibodies?

Answer 15

immune elimation phase

Question 16

When are antibodies first detected ?

Answer 16

Detectable antigen specific antibody ( Remember they are produced in the immune elimination phase however you cant see them because they are busy working on the rest of the antigen)

Question 17

Antigen removal is during what phase?

Answer 17

Catabolic decay phase

Question 18

What facilitates antigen recognition by B lymphocytes?

Answer 18

BCR

Question 19

The antigen binding region of the heavy and light chains are referred to as what?

Answer 19

Variable domains ( Vheavy V light)

Question 20

What determines the effector portion of the molecule?

Answer 20

Constant region