Cytokines Flashcards
IL-1
Activator of Th Cells, produced by APCs, precursor to NK cell and chemotaxis for macrophages and neutrophils
IL-2
redundancy of B-cell proliferation, negative feedback on Th2 (produced by Th1)
IL-3
Hematopoesis
IL-4
proliferation of B-cells, produced by Th2, negative effector on Th1,
works with IL-5 to make B-cells switch to IgE
IL-5
Synergistic effect with IL-4 to make B-cells switch to IgE
redundancy of B-cell proliferation
IL-6
Hematopoesis
IL-7
Hematopoesis
IL-8
Chemotaxis (CXCL8) for neutrophils, T-cells and basophils
also associated with skin
IL-10
anti-inflammatory
IL-11
Hematopoesis
IL-12
drives production of TNF
produces Th1 during leprosy
IL-13
product of Th2
leads to production of B-cells
IL-17
pro-inflammatory
RANTES
Eotoxin
SDF-1
Chemotaxis
IFN alpha, INF beta
requirements for NK cell
What kind of cell produces this INF gamma
NK cell produces this
TNF alpha and TNF beta are associated with what
associated with skin
fever inducer
pro-inflammatory
Bacterial Septic Shock is caused by what?
overproduction TNF alpha and IL-1 via macrophage
Toxic Shock Syn
TNF alpha and IL-1 via superantigens production of T-cells
What is the pathway of Th1 in leprosy
IL 12»» TH1»> IL-2, TNF beta, IFN-gamma»_space;»CMI» tuberculoid form
what is the pathway of Th2 in leprosy
IL 4»»TH2»»IL-4, IL-5, IL-10»>antibody production»>Lepromatous form
Cytokine therapy of INF alpha (roferon):
treatment of hep C, B, hairy cell leukemia
INF beta (avonex) is involved with what kind of treatment?
involved with treatment of MS
INF gamma (actimmine) is involved with what kind of treatement?
involved with treament of CGD
ELISPOT procedure does what
acid procedure quantifies cytokines
What can block IL-4 production?
INF gamma
Which family of cytokines interfere with viral replication?
INF alpha Beta and gamma
What does IL-15 do?
Activates NK-cells
What are chemokines?
Cytokines that promote chemotaxis
What is the function of IL-23?
regulator of T cells
