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MINI 4 > Cytokines > Flashcards

Cytokines Flashcards

1
Q

IL-1

A

Activator of Th Cells, produced by APCs, precursor to NK cell and chemotaxis for macrophages and neutrophils

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2
Q

IL-2

A

redundancy of B-cell proliferation, negative feedback on Th2 (produced by Th1)

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3
Q

IL-3

A

Hematopoesis

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4
Q

IL-4

A

proliferation of B-cells, produced by Th2, negative effector on Th1,
works with IL-5 to make B-cells switch to IgE

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5
Q

IL-5

A

Synergistic effect with IL-4 to make B-cells switch to IgE

redundancy of B-cell proliferation

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6
Q

IL-6

A

Hematopoesis

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7
Q

IL-7

A

Hematopoesis

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8
Q

IL-8

A

Chemotaxis (CXCL8) for neutrophils, T-cells and basophils

also associated with skin

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9
Q

IL-10

A

anti-inflammatory

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10
Q

IL-11

A

Hematopoesis

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11
Q

IL-12

A

drives production of TNF

produces Th1 during leprosy

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12
Q

IL-13

A

product of Th2

leads to production of B-cells

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13
Q

IL-17

A

pro-inflammatory

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14
Q

RANTES
Eotoxin
SDF-1

A

Chemotaxis

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15
Q

IFN alpha, INF beta

A

requirements for NK cell

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16
Q

What kind of cell produces this INF gamma

A

NK cell produces this

17
Q

TNF alpha and TNF beta are associated with what

A

associated with skin
fever inducer
pro-inflammatory

18
Q

Bacterial Septic Shock is caused by what?

A

overproduction TNF alpha and IL-1 via macrophage

19
Q

Toxic Shock Syn

A

TNF alpha and IL-1 via superantigens production of T-cells

20
Q

What is the pathway of Th1 in leprosy

A

IL 12»» TH1»> IL-2, TNF beta, IFN-gamma&raquo_space;»CMI» tuberculoid form

21
Q

what is the pathway of Th2 in leprosy

A

IL 4»»TH2»»IL-4, IL-5, IL-10»>antibody production»>Lepromatous form

22
Q

Cytokine therapy of INF alpha (roferon):

A

treatment of hep C, B, hairy cell leukemia

23
Q

INF beta (avonex) is involved with what kind of treatment?

A

involved with treatment of MS

24
Q

INF gamma (actimmine) is involved with what kind of treatement?

A

involved with treament of CGD

25
Q

ELISPOT procedure does what

A

acid procedure quantifies cytokines

26
Q

What can block IL-4 production?

A

INF gamma

27
Q

Which family of cytokines interfere with viral replication?

A

INF alpha Beta and gamma

28
Q

What does IL-15 do?

A

Activates NK-cells

29
Q

What are chemokines?

A

Cytokines that promote chemotaxis

30
Q

What is the function of IL-23?

A

regulator of T cells

MINI 4 (23 decks)

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