neurology Flashcards
seizure definition
a hypersynchronous activation of a group of neurons within the brain
isolated seizure definition
seizure lasting less than 5 mins
cluster seizure definition
2 or more seizures within 24hrs, with complete recovery in-between
status epilepticus definition
- seizures lasting longer than 5 mins
or - 2 seizures without complete recovery in-between
partial/focal seizure definition
asymmetric, one part of brain affected
partial/focal seizure clinical signs
- facial twitching
- hypersalivation
- behavioural changes
- consciousness maintained
simple-partial/focal seizure definition
no change in mentation
complex-partial/focal seizure definition
change in mentation
generalised (tonic/clonic) seizure definition
bilateral cerebral hemisphere involvement
generalised (tonic/clonic) seizure definition
bilateral cerebral hemisphere involvement
generalised (tonic/clonic) seizure clinical signs
- autonomic signs (urination/defecation)
- loss of consciousness
- pre-ictal, ictal and post ictal phases
pre-ictal phase of seizure (minutes)
- stage before seizure
- behaviour changes, altered mentation, attention seeking behaviour
ictal phase of seizure (<5 mins)
- loss of consciousness
- muscle contraction
- urination/defecation
post-ictal phase of seizure (mins-days)
- abnormal neurological signs
- wobbly, quiet, varies
extracranial causes of seizures
toxins
- slug bait, antifreeze, permethrin (cats), pesticides, ivermectin (collies), human drugs
metabolic
- portosystemic shunts, hypoglycaemia, hypercalcaemia
intracranial causes of seizures
structural
- brain tumour, inflammation, hydrocephalus
functional
- idiopathic epilepsy
idiopathic epilepsy
- most common causes of seizures
- animals diagnosed >6 months-6 years
- recurrent seizures
- normal inter-ictal neuro exam
- normal MRI, metabolic, CSF exam
diagnostics for seizures
- history
- bloods
- MRI with contrast
- CSF analysis
seizure mimic disorders
- narcolepsy/cataplexy
- fly-catching
- movement disorder
- syncope
- 3rd degree AV block
narcolepsy/cataplexy
- sleep-wake disorder
- inherited
- loss of muscle tone
- no autonomic signs
fly catching
- unknown cause
- minutes to hours
- normal mentation
- no autonomic signs
movement disorder
- episodic
- patient remains conscious
- spontaneous, involuntary movements
syncope
- fainting
- temp loss of consciousness
- due to reduced oxygen to brain
- cardiac/neuro/hypoglycaemia related
3rd degree AV block
- prolonged hypoxic event
- partial seizure like episodes
canine epileptoid cramping syndrome
- movement disorder common in border terriers
- conscious and responsive
- no autonomic signs
emergency management of seizures
- provide oxygen therapy
- place IV catheter
- diazepam 0.5-1mg/kg IV bolus, 2mg/kg rectally, 0.5mg/kg intranasally
- assess circulation and temp
- give mannitol IV if seizure lasts >15mins or cerebral oedema
- collect bloods
phone triage questions for seizures
- history of seizures
- exposed to any toxins
- head trauma?
- how long is the patient seizing for?
- how many seizures?
- is patient conscious and responsive
- autonomic signs? (urine, defecation)
- only transport patient when stable
nursing of seizure patients
- quiet ward
- lights dimmed
- bottom kennel (easy access when seizing)
- seizure plan on kennel with doses calculated
- seizure pack with medication drawn up
if patient seizures…
- note time
- call vet
- remove any dangers
- dim lights, reduce noise
- limit handling (just make them safe)
- monitor vitals
- don’t put hands in mouth
phenobarbital as medical management of seizures
- (epiphen)
- first line treatment, acts on GABA receptors in brain
- increases synaptic inhibition
- 2 weeks to become stable
side effects of phenobarbital for seizures
- hepatotoxicity (with high doses)
- sedation
- polydipsia/uria
- polyphagia
potassium bromide as medical management of seizures
- (libromide)
- first line anti-epileptic or in conjunction
- reduces neuronal excitability
- 4 months to become stable
side effects of potassium bromide as medical management of seizures
- gastric irritation
- nausea
- polydipsia/uria
- sedation
- pancreatitis
- can cause serious lung issues in cats
levetiracetam as medical management of seizures
- unknown method of action
- used as adjunct to other anti-epileptic drugs
- excreted unchanged in kidneys (fine with renal patients)
- orally bioavailable
- can cause ataxia, vomiting
imepitoin as medical management of seizures
- (pexion)
- only licensed for idiopathic epilepsy
- acts on GABA receptors reducing electrical activity
- can be used for noise phobias
- do not use in dogs with impaired hepatic, renal or CVS function
advice for clients
- nurse consult after initial diagnosis
- follow up calls to check in
- written communication
- support groups
- what does the owner need to know to care for pet at home
polyradiculoneuritis
- immune mediated disease
- affects myelin and/or axons (axonopathy)
- most common peripheral neuropathy in dogs
presentation of polyradiculoneuritis
- short-strided gate progressing to tetraparesis (weak limbs)
- dysphonia (change in voice)
diagnosis of polyradiculoneuritis
- accurate patient history
- physical and neuro exam
- EMG (electromyeligram)
- NCV (nerve conduction velocity)
- muscle and nerve biopsies
treatment of polyradiculoneuritis
intensive nursing care and physiotherapy
myasthenia gravis
- disease of neuromuscular transmission affecting NMJ (junctionopathy)
- congenital or required
- autoantibodies act on Ach receptor and alter function
- reduces number of functional receptors so muscles cant contract normally
- 3 types of the disease
presentation of myasthenia gravis
- muscle weakness and fatigue
- more obvious when exercising
- regurgitation due to oesophageal weakness
focal myasthenia gravis
- targets one muscle group
generalised myasthenia gravis
- targets all muscle groups
diagnosis of myasthenia gravis
- presumptive based on history and presentation
- thoracic radiographs- megaoesophagus
- edrophonium/tensilon test- patient can walk normally after
treatment of myasthenia gravis
- anticholinesterase therapy (bromides)
side effects: GI signs, hypersalivation
polymyositis
- immune mediated inflammatory myopathy
- infiltration of inflammatory cells into skeletal muscle
- idiopathic but can be associated with systemic disease
- focal (one muscle) or diffuse
presentation of polymyositis
- exercise intolerance and stiffened gate
- muscle atrophy, dysphonia, regurgitation (effects oesophagus)
- signs often wax and wane initially
diagnosis of polymyositis
- diagnosis of exclusion
- clinical history, biochemistry (increase in creatinine kinase), electrodiagnostic testing, muscle biopsy
treatment of polymyositis
- corticosteroids at immunosuppressive doses
- azothrioprine can be used along side steroids if patients cant handle their side effects
treatment of aspiration pneumonia
- early admin of antibiotics
- oxygen therapy, iv fluids
- walking, turning patients
- raised eating balls of food (wet food)
- mechanical ventilation if necessary
aspiration pneumonia
- inhalation of GI contents into lungs
- pulmonary damage and inflammation
- coughing, tachypnoea, crackles on auscultation
pressure sores
- common complication for recumbent patients
- increased pressure over bony prominences
- leads to ischaemia and necrosis
prevention of pressure sores
- thick padded bedding
- turning every 2-4hrs
- donut bandage
- porous bedding
- incontinence pads
- non slippery floors
- physiotherapy
treatment of pressure sores
- bandages and commercial boots useful
- debride if necessary
- antibiotics if infected
muscle contracture
recumbancy and immobilisation leads to:
- adaptive shortening of muscles and soft tissues
- inelasticity of soft tissues
considerations for neurological diseases
- temperament
- client expectations, limits
- disease process
- other diseases
spinal cord definition
extracranial part of CNS
spinal column definition
encases and protects spinal cord and nerves
patient workup steps
- history
- physical exam
- neuro exam
- differential diagnosis
- diagnostic tests
- diagnosis/prognosis
- treatment
when is a neuro exam indicated?
- seizures
- behavioural changes
- gait abnormalities
- change in posture, positioning