Neuro Pharm - Epilepsy drugs Flashcards
Ethosuxamide MOA, use, AE
MOA:
- Blocks THALAMIC T-type Ca++ channels
use:
- absence seizures
AE:
- Fatigue
- GI
- Headache
- Itching (urticaria)
- SJS
Ethosuxamide MOA, use, AE
MOA:
- Blocks THALAMIC T-type Ca++ channels
use:
- absence seizures
AE:
- Fatigue
- GI
- Headache
- Itching (urticaria)
- SJS
Ethosuxamide MOA, use, AE
MOA:
- Blocks THALAMIC T-type Ca++ channels
use:
- absence seizures
AE:
- Fatigue
- GI
- Headache
- Itching (urticaria)
- SJS
Benzo’s for seizures
Loazepam
Diazepam
Benzo’s for seizures: MOA, use, AE
lorazepam, diazepam
MOA:
- increase GABAA channel opening frequency
Use:
- DOC acute status epilepticus
- eclampsia seizures (first line is MgSO4)
AE:
- sedation
- tolerance
- respiratory depression
- dependence
Benzo’s for seizures: MOA, use, AE
lorazepam, diazepam
MOA: increase GABAA channel opening frequency
Use:
- DOC acute status epilepticus
- eclampsia seizures (first line is MgSO4)
AE:
- sedation
- tolerance
- respiratory depression
- dependence
Benzo’s for seizures: MOA, use, AE
lorazepam, diazepam
MOA: increase GABAA channel opening frequency
Use:
- DOC acute status epilepticus
- eclampsia seizures (first line is MgSO4)
AE:
- sedation
- tolerance
- respiratory depression
- dependence
Phenytoin: MOA, use, AE
MOA:
- increase Na+ channel INactivation
- zero-order kinetics
- Fosphenytoin for parenteral use
Use:
- DOC status epilepticus prophylaxis
- simple, complex, tonic-clonic
AE:
- Gingival hyperplasia
- Hirsutism
- SLE-like
- P450 induction
- peripheral neuropathy
- megaloblastic anemia
- nystagmus, diplopia, ataxia
- teratogen (fetal hydantoin syndrome)
- LAD
- SJS
- Osteopenia
Phenytoin: MOA, use, AE
MOA:
- increase Na+ channel INactivation
- zero-order kinetics
- Fosphenytoin for parenteral use
Use:
- DOC status epilepticus prophylaxis
- simple, complex, tonic-clonic
AE:
- Gingival hyperplasia
- Hirsutism
- SLE-like
- P450 induction
- peripheral neuropathy
- megaloblastic anemia
- nystagmus, diplopia, ataxia
- teratogen (fetal hydantoin syndrome)
- LAD
- SJS
- Osteopenia
Phenytoin: MOA, use, AE
MOA:
- increase Na+ channel INactivation
- zero-order kinetics
- Fosphenytoin for parenteral use
Use:
- DOC status epilepticus prophylaxis
- simple, complex, tonic-clonic
AE:
- Gingival hyperplasia
- Hirsutism
- SLE-like
- P450 induction
- peripheral neuropathy
- megaloblastic anemia
- nystagmus, diplopia, ataxia
- teratogen (fetal hydantoin syndrome)
- LAD
- SJS
- Osteopenia
Carbamazepine: MOA, use, AE
MOA:
- Na+ channel INactivatoin
Use:
- DOC simple seizures
- DOC complex seizures
- tonic-clonic
- DOC trigeminal neuralgia
- Bipolar mood stabilizer
AE:
- Blood dyscrasias (aganulocytosis and aplastic anemia)
- SIADH
- diplopia and ataxia
- liver toxicity
- P450 induction
- teratogen
- SJS
Carbamazepine: MOA, use, AE
MOA:
- Na+ channel INactivatoin
Use:
- DOC simple seizures
- DOC complex seizures
- tonic-clonic
- DOC trigeminal neuralgia
- Bipolar mood stabilizer
AE:
- Blood dyscrasias (aganulocytosis and aplastic anemia)
- SIADH
- diplopia and ataxia
- liver toxicity
- P450 induction
- teratogen
- SJS
Carbamazepine: MOA, use, AE
MOA:
- Na+ channel INactivatoin
Use:
- DOC simple seizures
- DOC complex seizures
- tonic-clonic
- DOC trigeminal neuralgia
- Bipolar mood stabilizer
AE:
- Blood dyscrasias (aganulocytosis and aplastic anemia)
- SIADH
- diplopia and ataxia
- liver toxicity
- P450 induction
- teratogen
- SJS
Valproic acid: MOA, use, AE
MOA:
- Blocks NMDA channels
- Blocks K+ currents
- increases Na+ channel INactivatoin
- Increase GABA via inhibiting GABA transaminases
Use:
- DOC tonic-clonic
- simple, complex, myoclonic, tonic-clonic with absence
- bipolar mood stabolizer
AE:
- rare but fatal hepatotoxicity
- Neural tube defects (blocks intestinal folate absorption)
- tremor
- weight gain
- GI
Valproic acid: MOA, use, AE
MOA:
- Blocks NMDA channels
- Blocks K+ currents
- increases Na+ channel INactivatoin
- Increase GABA via inhibiting GABA transaminases
Use:
- DOC tonic-clonic
- simple, complex, myoclonic, tonic-clonic with absence
- bipolar mood stabolizer
AE:
- rare but fatal hepatotoxicity
- Neural tube defects (blocks intestinal folate absorption)
- tremor
- weight gain
- GI
Valproic acid: MOA, use, AE
MOA:
- Blocks NMDA channels
- Blocks K+ currents
- increases Na+ channel INactivatoin
- Increase GABA via inhibiting GABA transaminases
Use:
- DOC tonic-clonic
- simple, complex, myoclonic, tonic-clonic with absence
- bipolar mood stabolizer
AE:
- rare but fatal hepatotoxicity
- Neural tube defects (blocks intestinal folate absorption)
- tremor
- weight gain
- GI
Gabapentin: MOA, use, AE
MOA:
- Inhibits high-volatage-activated Ca++ channels
Use:
- simple and complex seizures
- peripheral neuropahty
- Post-herprtic neuralgia
AE:
- sedation
- ataxia
Gabapentin: MOA, use, AE
MOA:
- Inhibits high-volatage-activated Ca++ channels
Use:
- simple and complex seizures
- peripheral neuropahty
- Post-herprtic neuralgia
AE:
- sedation
- ataxia
Gabapentin: MOA, use, AE
MOA:
- Inhibits high-volatage-activated Ca++ channels
Use:
- simple and complex seizures
- peripheral neuropahty
- Post-herprtic neuralgia
AE:
- sedation
- ataxia
Phenobarbital: MOA, use, AE
MOA:
- Increases duration of GABAA channel opening
use:
- DOC seizures in neonates
- simple, complex, tonic-clonic
AE:
- P450 induction
- sedation
- tolerance
- dependence
- cardio-respiratory depression
Phenobarbital: MOA, use, AE
MOA:
- Increases duration of GABAA channel opening
use:
- DOC seizures in neonates
- simple, complex, tonic-clonic
AE:
- P450 induction
- sedation
- tolerance
- dependence
- cardio-respiratory depression
Phenobarbital: MOA, use, AE
MOA:
- Increases duration of GABAA channel opening
use:
- DOC seizures in neonates
- simple, complex, tonic-clonic
AE:
- P450 induction
- sedation
- tolerance
- dependence
- cardio-respiratory depression
Topirimate: MOA, use, AE
MOA:
- Blocks Na+ channels
- Increases GABA action
Use:
- tonic clonic, simple, complex
- migraine prophylaxis
- pseudotumour cerebri
AE:
- weight loss
- kidney stones
- mental dulling
- sedation
Topirimate: MOA, use, AE
MOA:
- Blocks Na+ channels
- Increases GABA action
Use:
- tonic clonic, simple, complex
- migraine prophylaxis
- pseudotumour cerebri
AE:
- weight loss
- kidney stones
- mental dulling
- sedation
Topirimate: MOA, use, AE
MOA:
- Blocks Na+ channels
- Increases GABA action
Use:
- tonic clonic, simple, complex
- migraine prophylaxis
- pseudotumour cerebri
AE:
- weight loss
- kidney stones
- mental dulling
- sedation
Lamotrigine: MOA, use, AE
MOA:
- Blocks VG-Na+ channels
Use:
- simple, complex, tonic-clonic, absence
- Bipolar disorder for maintenance or depressive phase
AE:
- SJS (mus tbe titrated slowly)
Levatiracetam
Unknown action
partial, complex, tonic-clonic
Tigabine: MOA and use
Inhibit GABA reuptake
simple, complex
Vigabatrin: MOA and use
IRREVERSIBLY inhibits GABA transaminases ot increase GABA
simple, complex
SJS
Prodrome: malaise and fever
Then rapid onset of erythematous/puriric macules (oral, occualr, genital)
Increase surface area = epidermal necrosis and sloghing