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DRUGS > Neuro Pharm - Epilepsy drugs > Flashcards

Neuro Pharm - Epilepsy drugs Flashcards

1
Q

Ethosuxamide MOA, use, AE

A

MO​A:

  • Blocks THALAMIC T-type Ca++ channels

use:

  • absence seizures

AE:

  • Fatigue
  • GI
  • Headache
  • Itching (urticaria)
  • SJS
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2
Q

Ethosuxamide MOA, use, AE

A

MOA:

  • Blocks THALAMIC T-type Ca++ channels

use:

  • absence seizures

AE:

  • Fatigue
  • GI
  • Headache
  • Itching (urticaria)
  • SJS
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3
Q

Ethosuxamide MOA, use, AE

A

MOA:

  • Blocks THALAMIC T-type Ca++ channels

use:

  • absence seizures

AE:

  • Fatigue
  • GI
  • Headache
  • Itching (urticaria)
  • SJS
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4
Q

Benzo’s for seizures

A

Loazepam

Diazepam

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5
Q

Benzo’s for seizures: MOA, use, AE

A

lorazepam, diazepam

MOA:

  • increase GABAA channel opening frequency

Use:

  • DOC acute status epilepticus
  • eclampsia seizures (first line is MgSO4)

AE:

  • sedation
  • tolerance
  • respiratory depression
  • dependence
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6
Q

Benzo’s for seizures: MOA, use, AE

A

lorazepam, diazepam

MOA: increase GABAA channel opening frequency

Use:

  • DOC acute status epilepticus
  • eclampsia seizures (first line is MgSO4)

AE:

  • sedation
  • tolerance
  • respiratory depression
  • dependence
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7
Q

Benzo’s for seizures: MOA, use, AE

A

lorazepam, diazepam

MOA: increase GABAA channel opening frequency

Use:

  • DOC acute status epilepticus
  • eclampsia seizures (first line is MgSO4)

AE:

  • sedation
  • tolerance
  • respiratory depression
  • dependence
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8
Q

Phenytoin: MOA, use, AE

A

MOA:

  • increase Na+ channel INactivation
  • zero-order kinetics
  • Fosphenytoin for parenteral use

Use:

  • DOC status epilepticus prophylaxis
  • simple, complex, tonic-clonic

AE:

  • Gingival hyperplasia
  • Hirsutism
  • SLE-like
  • P450 induction
  • peripheral neuropathy
  • megaloblastic anemia
  • nystagmus, diplopia, ataxia
  • teratogen (fetal hydantoin syndrome)
  • LAD
  • SJS
  • Osteopenia
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9
Q

Phenytoin: MOA, use, AE

A

MOA:

  • increase Na+ channel INactivation
  • zero-order kinetics
  • Fosphenytoin for parenteral use

Use:

  • DOC status epilepticus prophylaxis
  • simple, complex, tonic-clonic

AE:

  • Gingival hyperplasia
  • Hirsutism
  • SLE-like
  • P450 induction
  • peripheral neuropathy
  • megaloblastic anemia
  • nystagmus, diplopia, ataxia
  • teratogen (fetal hydantoin syndrome)
  • LAD
  • SJS
  • Osteopenia
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10
Q

Phenytoin: MOA, use, AE

A

MOA:

  • increase Na+ channel INactivation
  • zero-order kinetics
  • Fosphenytoin for parenteral use

Use:

  • DOC status epilepticus prophylaxis
  • simple, complex, tonic-clonic

AE:

  • Gingival hyperplasia
  • Hirsutism
  • SLE-like
  • P450 induction
  • peripheral neuropathy
  • megaloblastic anemia
  • nystagmus, diplopia, ataxia
  • teratogen (fetal hydantoin syndrome)
  • LAD
  • SJS
  • Osteopenia
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11
Q

Carbamazepine: MOA, use, AE

A

MOA:

  • Na+ channel INactivatoin

Use:

  • DOC simple seizures
  • DOC complex seizures
  • tonic-clonic
  • DOC trigeminal neuralgia
  • Bipolar mood stabilizer

AE:

  • Blood dyscrasias (aganulocytosis and aplastic anemia)
  • SIADH
  • diplopia and ataxia
  • liver toxicity
  • P450 induction
  • teratogen
  • SJS
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12
Q

Carbamazepine: MOA, use, AE

A

MOA:

  • Na+ channel INactivatoin

Use:

  • DOC simple seizures
  • DOC complex seizures
  • tonic-clonic
  • DOC trigeminal neuralgia
  • Bipolar mood stabilizer

AE:

  • Blood dyscrasias (aganulocytosis and aplastic anemia)
  • SIADH
  • diplopia and ataxia
  • liver toxicity
  • P450 induction
  • teratogen
  • SJS
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13
Q

Carbamazepine: MOA, use, AE

A

MOA:

  • Na+ channel INactivatoin

Use:

  • DOC simple seizures
  • DOC complex seizures
  • tonic-clonic
  • DOC trigeminal neuralgia
  • Bipolar mood stabilizer

AE:

  • Blood dyscrasias (aganulocytosis and aplastic anemia)
  • SIADH
  • diplopia and ataxia
  • liver toxicity
  • P450 induction
  • teratogen
  • SJS
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14
Q

Valproic acid: MOA, use, AE

A

MOA:

  • Blocks NMDA channels
  • Blocks K+ currents
  • increases Na+ channel INactivatoin
  • Increase GABA via inhibiting GABA transaminases

Use:

  • DOC tonic-clonic
  • simple, complex, myoclonic, tonic-clonic with absence
  • bipolar mood stabolizer

AE:

  • rare but fatal hepatotoxicity
  • Neural tube defects (blocks intestinal folate absorption)
  • tremor
  • weight gain
  • GI
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15
Q

Valproic acid: MOA, use, AE

A

MOA:

  • Blocks NMDA channels
  • Blocks K+ currents
  • increases Na+ channel INactivatoin
  • Increase GABA via inhibiting GABA transaminases

Use:

  • DOC tonic-clonic
  • simple, complex, myoclonic, tonic-clonic with absence
  • bipolar mood stabolizer

AE:

  • rare but fatal hepatotoxicity
  • Neural tube defects (blocks intestinal folate absorption)
  • tremor
  • weight gain
  • GI
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16
Q

Valproic acid: MOA, use, AE

A

MOA:

  • Blocks NMDA channels
  • Blocks K+ currents
  • increases Na+ channel INactivatoin
  • Increase GABA via inhibiting GABA transaminases

Use:

  • DOC tonic-clonic
  • simple, complex, myoclonic, tonic-clonic with absence
  • bipolar mood stabolizer

AE:

  • rare but fatal hepatotoxicity
  • Neural tube defects (blocks intestinal folate absorption)
  • tremor
  • weight gain
  • GI
17
Q

Gabapentin: MOA, use, AE

A

MOA:

  • Inhibits high-volatage-activated Ca++ channels

Use:

  • simple and complex seizures
  • peripheral neuropahty
  • Post-herprtic neuralgia

AE:

  • sedation
  • ataxia
18
Q

Gabapentin: MOA, use, AE

A

MOA:

  • Inhibits high-volatage-activated Ca++ channels

Use:

  • simple and complex seizures
  • peripheral neuropahty
  • Post-herprtic neuralgia

AE:

  • sedation
  • ataxia
19
Q

Gabapentin: MOA, use, AE

A

MOA:

  • Inhibits high-volatage-activated Ca++ channels

Use:

  • simple and complex seizures
  • peripheral neuropahty
  • Post-herprtic neuralgia

AE:

  • sedation
  • ataxia
20
Q

Phenobarbital: MOA, use, AE

A

MOA:

  • Increases duration of GABAA channel opening

use:

  • DOC seizures in neonates
  • simple, complex, tonic-clonic

AE:

  • P450 induction
  • sedation
  • tolerance
  • dependence
  • cardio-respiratory depression
21
Q

Phenobarbital: MOA, use, AE

A

MOA:

  • Increases duration of GABAA channel opening

use:

  • DOC seizures in neonates
  • simple, complex, tonic-clonic

AE:

  • P450 induction
  • sedation
  • tolerance
  • dependence
  • cardio-respiratory depression
22
Q

Phenobarbital: MOA, use, AE

A

MOA:

  • Increases duration of GABAA channel opening

use:

  • DOC seizures in neonates
  • simple, complex, tonic-clonic

AE:

  • P450 induction
  • sedation
  • tolerance
  • dependence
  • cardio-respiratory depression
23
Q

Topirimate: MOA, use, AE

A

MOA:

  • Blocks Na+ channels
  • Increases GABA action

Use:

  • tonic clonic, simple, complex
  • migraine prophylaxis
  • pseudotumour cerebri

AE:

  • weight loss
  • kidney stones
  • mental dulling
  • sedation
24
Q

Topirimate: MOA, use, AE

A

MOA:

  • Blocks Na+ channels
  • Increases GABA action

Use:

  • tonic clonic, simple, complex
  • migraine prophylaxis
  • pseudotumour cerebri

AE:

  • weight loss
  • kidney stones
  • mental dulling
  • sedation
25
Q

Topirimate: MOA, use, AE

A

MOA:

  • Blocks Na+ channels
  • Increases GABA action

Use:

  • tonic clonic, simple, complex
  • migraine prophylaxis
  • pseudotumour cerebri

AE:

  • weight loss
  • kidney stones
  • mental dulling
  • sedation
26
Q

Lamotrigine: MOA, use, AE

A

MOA:

  • Blocks VG-Na+ channels

Use:

  • simple, complex, tonic-clonic, absence
  • Bipolar disorder for maintenance or depressive phase

AE:

  • SJS (mus tbe titrated slowly)
27
Q

Levatiracetam

A

Unknown action

partial, complex, tonic-clonic

28
Q

Tigabine: MOA and use

A

Inhibit GABA reuptake

simple, complex

29
Q

Vigabatrin: MOA and use

A

IRREVERSIBLY inhibits GABA transaminases ot increase GABA

simple, complex

30
Q

SJS

A

Prodrome: malaise and fever

Then rapid onset of erythematous/puriric macules (oral, occualr, genital)

Increase surface area = epidermal necrosis and sloghing

DRUGS (41 decks)

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