Drug Reactions Flashcards by Dallas Toon

(cardiovascular) Coronary vasospasm

Cocaine, sumatriptan, ergot alkaloids

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(cardiovascular) Cutaneous flushing

Vancomycin, Adenosine, Niacin, Ca2+ channel blockers; Mnemonic: “VANC”

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(cardiovascular) Dilated cardiomyopathy

Doxorubicin, daunorubicin

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(cardiovascular) Torsades de pointes

Class III (e.g., sotalol) and class IA (e.g., quinidine) antiarrhythmics, macrolide antibiotics, antipsychotics, TCAs

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(endocrine/reproductive) Adrenocortical insufficiency

HPA suppression 2¡ to glucocorticoid withdrawal

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(endocrine/reproductive) Hot flashes

Tamoxifen, clomiphene

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(endocrine/reproductive) Hyperglycemia

Tacrolimus, Protease inhibitors, Niacin, HCTZ, beta-blockers, Corticosteroids; Mnemonic: “Taking Pills Necessitates Having Blood Checked”

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(endocrine/reproductive) Hypothyroidism

Lithium, amiodarone, sulfonamides

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(GI) Acute cholestatic hepatitis, jaundice

Erythromycin

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(GI) Diarrhea

Metformin, Erythromycin, Colchicine, Orlistat, Acarbose; Mnemonic: “Might Excite Colon On Accident”

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(GI) Focal to massive hepatic necrosis

Halothane, Amanita phalloides (death cap mushroom), Valproic acid, Acetaminophen; Mnemonic: Liver “HAVAc”

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(GI) Hepatitis

INH

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(GI) Pancreatitis

Didanosine, Corticosteroids, Alcohol, Valproic acid, Azathioprine, Diuretics (furosemide, HCTZ); Mnemonic: “Drugs Causing A Violent Abdominal Distress”

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(GI) Pseudomembranous colitis

Clindamycin, ampicillin, cephalosporins ; Mnemonic: Antibiotics predispose to superinfection by resistant C. difficile

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(Hematologic) Agranulocytosis

Dapsone, Clozapine, Carbamazepine, Colchicine, Methimazole, Propylthiouracil; Mnemonic: Drugs CCCrush Myeloblasts and Promyelocytes

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(Hematologic) Aplastic anemia

Carbamazepine, Methimazole, NSAIDs, Benzene, Chloramphenicol, Propylthiouracil; Mnemonic: Can’t Make New Blood Cells Properly

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(Hematologic) Direct Coombs- positive hemolytic anemia

Methyldopa, penicillin

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(Hematologic) Gray baby syndrome

Chloramphenicol

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(Hematologic) Hemolysis in G6PD deficiency

INH, Sulfonamides, Dapsone, Primaquine, Aspirin, Ibuprofen, Nitrofurantoin; Mnemonic: Hemolysis IS D PAIN

(Hematologic) Megalo”blast”ic anemia

Phenytoin, Methotrexate, Sulfa drugs; Mnemonic: Having a blast with PMS

(Hematologic) Thrombocytopenia

Heparin, cimetidine

(Hematologic) Thrombotic complications

OCPs (e.g., estrogens)

(Musculoskeletal/skin/connective tissue) Fat redistribution

Protease inhibitors, Glucocorticoids; Mnemonic: Fat PiG

(Musculoskeletal/skin/connective tissue) Gingival hyperplasia

Phenytoin, verapamil, cyclosporine, nifedipin

(Musculoskeletal/skin/connective tissue) Hyperuricemia (gout)

Pyrazinamide, Thiazides, Furosemide, Niacin, Cyclosporine; Mnemonic: Painful Tophi and Feet Need Care

(Musculoskeletal/skin/connective tissue) Myopathy

Fibrates, niacin, colchicine, hydroxychloroquine, interferon-, penicillamine, statins, glucocorticoids

(Musculoskeletal/skin/connective tissue) Osteoporosis

Corticosteroids, heparin

(Musculoskeletal/skin/connective tissue) Photosensitivity

Sulfonamides, Amiodarone, Tetracyclines, 5-FU; Mnemonic: "SAT For Photo"

(Musculoskeletal/skin/connective tissue) Rash (Stevens- Johnson syndrome)

Antiepileptic drugs (ethosuximide, carbamazepine, lamotrigine, phenytoin, phenobarbital), Allopurinol, Sulfa drugs, Penicillin; Mnemonic: "Steven Johnson has epileptic Allergy to Sulfa drugs and Penicillin"

(Musculoskeletal/skin/connective tissue) SLE-like syndrome

Sulfa drugs, Hydralazine, INH, Procainamide, Phenytoin, Etanercept; Mnemonic: Having lupus is "SHIPP-E"

(Musculoskeletal/skin/connective tissue) Teeth discoloration

Tetracyclines

(Musculoskeletal/skin/connective tissue) Tendonitis, tendon rupture, and cartilage damage

Fluoroquinolones

(Neurologic) Cinchonism

Quinidine, quinine

(Neurologic) Parkinson-like syndrome

Antipsychotics, Reserpine, Metoclopramide ; Mnemonic: Cogwheel rigidity of ARM

(Neurologic) Seizures

INH (vitamin B6 deficiency), Bupropion, Imipenem/cilastatin, Tramadol, Enflurane, Metoclopramide; Mnemonic: With seizures, I BITE My tongue

(Neurologic) Tardive dyskinesia

Antipsychotics, metoclopramide

(Renal/genitourinary) Diabetes insipidus

Lithium, demeclocycline

(Renal/genitourinary) Fanconi syndrome

Expired tetracycline

(Renal/genitourinary) Hemorrhagic cystitis

Cyclophosphamide, ifosfamide ; Rx:Prevent by co-administering with mesna

(Renal/genitourinary) Interstitial nephritis

Methicillin, NSAIDs, furosemide

(Renal/genitourinary) SIADH

Carbamazepine, Cyclophosphamide, SSRIs ; Mnemonic: Can't Concentrate Serum Sodium

(Respiratory) Dry cough

ACE inhibitors

(Respiratory) Pulmonary fibrosis

Bleomycin, Amiodarone, Busulfan, Methotrexate; Mnemonic: Breathing Air Badly from Medications

Antimuscarinic

Atropine, TCAs, H1-blockers, antipsychotics

Disulfiram-like reaction

Metronidazole, certain cephalosporins, griseofulvin, procarbazine, 1st-generation sulfonylureas

Nephrotoxicity/ ototoxicity

Aminoglycosides, vancomycin, loop diuretics, cisplatin