Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

DRUGS > Anti-cancer > Flashcards

Anti-cancer Flashcards

1
Q

6-MP activation

A

HGPRT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

6-MP breakdown

A

XO

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

6-MP toxicity

A

myelosuppression, hepatotoxicity (hepatitis and cholestasis)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Increase 6-MP toxicity via:

A

alloputinol or febuxostat (block XO)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

6-MP MOA

A

Purine analog

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Cladiribine MOA

A

purine analog

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Rx of Hairy cell

A

Cladribine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Cladribine toxicity

A

myelo, nephrotoxicity, neurotoxicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Cytarabine MOA

A

pyrimidine analog

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Cytarabine AE

A

panCYTopenia (leuko, thrombo, megaloblastic anemia)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

5-FU MOA

A

pyrimidine analog; inhibits thymidilate synthase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Purine analogs

A

6-MP, azathioprine, cladribine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

pyrimidine analogs

A

cytarabine, 5-FU

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Leucovorin: when it works and doesn’t work

A

works for MTX; does NOT work for 5-FU (actually potentiates it)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

MTX MOA

A

folic acid analog; competitively inhibits DHF reductase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

MTX Rx

A

cancers: leukemiaa (ALL), lymphomas, chorioCA, sarcomas.

Non-neoplastic: ectopic pregnancy (medical abortion), RA, psoriasis, IBD, vasculitis.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

MTX AE

A

myelo (rx = leucovorin), hepatoxoicity, mucocytis, pulmonary fibrosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

hydroxyurea MOA

A

inhibits ribonucleotide reductase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

S-phase drugs

A

6-MP, 6-TG, azathioprine, cladribine, cytarabine, 5-FU, MTX, hydroxyurea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Anti-tumour ABx

A

Bleomycin, dactinomycin, doxorubicin, danaurubucin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Bleomycin MOA

A

Free-radical -> DNA strand breaks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Bleomycin AE

A

Pulmonary fibrosis, skin hyper pigmentation, mucocytis, *MINIMAL myelosuppresion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Doxo/daunorubicin MOA

A

Intercalates into DNA -> breaks + free radicals

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

doxo/daunorubicin AE

A

dilated cardiomyopathy, alopecia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
doxo/daunorubicin AE Rx
Dexrazoxane
26
Dactinomycin MOA
intercalates
27
Dactinomycin use
Child tumours (wilms, ewing, rhabdomyosarcoma)
28
akylating agents act on what stage of cell cycle?
G1
29
Name all alkylating agents
Busulfan, cycloforfamide, isofosfamide, nitrosureas (___mustanes + streptozocin)
30
Busulfan MOA
cross-links
31
busulfan AE
pulmonary fibrosis , hyperpigmentation
32
busulfan use
CML and ablating pt bone marrow before transplant
33
cyclophosphamide/isoforphamide MOA
cross-links @ G-N7
34
cyclophosphamide/isophosphamide AE + Rx
hemorrhagic cystitis; prevent/rx with mesna
35
nitrosureas (___mustines + streptozocin MOA/use
Bioactivated, cross BBB, crosslink DNA. BBB .: rx brain tumours (i.e. GBM)
36
nitrosureas (___mustines + streptozocin AE
CNS effects (confusion, dizzy, ataxia)
37
paclitaxel MOA
hyperstabilize polymerized MTs .: prevent anaphase
38
paclitaxel AE
myelo, alopecia, hypersensitivity
39
vincristine/vinblastin MOA
inhibit b-tubulin polymerization
40
vincristine AE
neurotoxicity (areflexia, peripheral neuritis, paralytic ileus)
41
vinblatine AE
myelosuppression
42
cisplatin/carboplatin MOA
crosslink DNA
43
Cisplatin/carboplatin AE and Rx
Ototoxicity and nephrotoxicity (prevent with amifortine (free radical scavenger) and chloride saline diuresis
44
etoposide/teniposide MOA
inhibit topo II --> DNA degradation
45
irinotecan/topotecan
inhibit topo I (prevent unwinding and replication)
46
Bevacizumab MOA and AE
MOA = VEGF; AE = bleed, clot, impaired wound healing
47
Erlotinib
MOA = EGFR
48
Imatinib MOA
tyrosine kinase of Bcr-Abl and c-kit
49
imatinib AE
fluid retention
50
Rituximab MOA
CD20 (so all non-hodgkin lymphomas)
51
Rituximab AE
PML
52
Tamoxifen MOA
Antagonist: breast Agonist: endometrium, bone
53
Tamoxifen use:
breast cancer prophylaxis AND treatment
54
Raloxifen MOA
Antagonist: breast and endometrium Agonist: bone
55
Raloxifen use:
breast cancer prophylaxis ONLY, OP prevention
56
Traztuzumab MOA/use
HER-2-nu (c-erb-B2) antibody. | Her-2-nu breast cancer and gastric cancer
57
HER-2-nu mechanism
tyrosine kinase receptor
58
Traztuzumab AE
Cardiotoxicity
59
Vemurafenib MOA
small molecule inhibitor of BRAF
60
Vemurafenib use
Malignant melanoma

DRUGS (41 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions