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DRUGS > NEURO - Glaucoma > Flashcards

NEURO - Glaucoma Flashcards

1
Q

Accommodation receptor and muscle

A

M3 - ciliary

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2
Q

Miosis receptor and muscle

A

M3 - sphincter pupillae

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3
Q

Mydriasis receptor and muscle

A

a1 - Radial muscle (dilator pupillae)

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4
Q

Increase aqueous humour production receptor

A

b2

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5
Q

Decrease aqueous humour production receptor

A

a2

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6
Q

alpha agonists for glaucoma

A

Epinepherine (a1)

Brimonidine (a2)

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7
Q

Epinephrine MOA

A

a1 vasoconstriction causing decreased aqueous humour production

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8
Q

Epinephrine AE

A

Mydriasis (a1), so CANNOT use for closed-angle glaucoma

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9
Q

Brimonidine MOA

A

a2 agonist decreasing aqueous humour production

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10
Q

Brimonidine AE

A 
a2 agonist (decrease sympathetics), so causes:
blurry vision
ocular hyperemia
Foreign-body sensation
ocular allergic reactions
ocular pruritus
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11
Q

beta-blockers for glaucoma

A

timidol
betaxolol
carteolol

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12
Q

b-blockers in glaucoma MOA

A

decease aqueous humour production

*No pupillary/vision changes because that is via M3 and a1

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13
Q

Diuretics in glaucoma

A

Acetazolamide

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14
Q

acetazolamide MOA

A

inhibit CA, which decreases aqueous humour production

*No pupillary/vision changes because that is via M3 and a1

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15
Q

Cholinomimetics in glaucoma

A

Direct: pilocarpine, carbachol

Indirect: physostigmine, chothiophate

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16
Q

Direct cholinomimetic MOA

A

pilocarpine, carbachol

Contract ciliary muscles (M3) to open trabecular meshwork and increase aqueous humour outflow

17
Q

Cholinomimetics in glaucoma AE

A

Miosis (another action via M3, but via sphincter pupillae)

Cyclospasm (via ciliary contraction)

18
Q

Indirect cholinomimetic MOA

A

Physostigmine, echothiophate

Physostigmine for emergencies - very effective opener of canal os schlemm

19
Q

Prostaglandins in glaucoma

A

Latanoprost (PGF-2a)

20
Q

Latanoprost MOA

A

PGF-2a, increases outflow of aqueous humour

21
Q

Latanoprost AE

A

Darkening (browning) of iris

used off-label for eyelash growth

22
Q

Glaucoma treatment contraindicated in closed-angle glaucoma

A

epinepherine (because of mydriasis)

23
Q

glaucoma rx causing iris browning

A

latanoprost

24
Q

glaucoma rx that won’t affect vision/accomadation

A

beta-blockers or acetazolamide

DRUGS (41 decks)

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