CARDIO - Lipid lowering agents Flashcards
Statins
[Lovastatin, Pravastatin, simvastatin, atorvastatin, rosuvastatin]
Statin MOA
[Lovastatin, Pravastatin, simvastatin, atorvastatin, rosuvastatin]
Blocks HMG-CoA Redutase (can’t make mevalonate to make cholesterol)
Statin Lipid effects
Decrease LDL
Decrease TAG
Increase HDL
Statins AE
Hepatotoxicity
Myopathy (increase with fibrates and niacin)
Lipid lowering agent that decreases mortality in CAD patients
Statins
Fibrates:
Gemfibrozil, Clofibrate, bezafibrate, fenofibrate
Fibrates MOA
Activates PPAR-a (HDL synthesis)
Upregulates LPL
Fibrates lipid effects
Decrease LDL
Decrease TAG
Increase HDL
Fibrates toxicity
Myopathy (increase with statins)
Gallstones
Niacin MOA
Decrease FA release (by inhibiting HSL)
Decrease VLDL synthesis
Decrease HDL clearance
Niacin lipid effects
Decrease LDL
Decrease TAG
Increase HDL
Niacin toxicity
Flushing and pruritis (stop with NSAIDs)
Hyperglycemia (acanthosis)
Hyperuricemia (gout)
Hepatotoxicity
Bile acid resins:
cholestyramine, cholestipol, cholesevelam
Bile acid resin MOA
Bind bile in intestines, prevent absorption in ileum
Bile acid resin lipid effects
Decrease LDL
Increase TAG
Increase HDL
bile acid resin toxicity
Nausea, bloating, cramps
Decreased absorption of other drugs and fat-soluble vitamins
Ezetemibe MOA
Prevent cholesterol absorption in small intestine
Ezetimibe lipid effects
Deceased LDL
Ezetimibe toxicity
Diarrhea
Hepatotoxicity with statins
Omega-3-FA MOA
Decrease TAG synthesis
Omega-3-FA lipid effects
Decrease TAG
Omega-3-FA toxicity
Nausea
