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DRUGS > CARDIO - Lipid lowering agents > Flashcards

CARDIO - Lipid lowering agents Flashcards

1
Q

Statins

A

[Lovastatin, Pravastatin, simvastatin, atorvastatin, rosuvastatin]

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2
Q

Statin MOA

[Lovastatin, Pravastatin, simvastatin, atorvastatin, rosuvastatin]

A

Blocks HMG-CoA Redutase (can’t make mevalonate to make cholesterol)

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3
Q

Statin Lipid effects

A

Decrease LDL

Decrease TAG

Increase HDL

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4
Q

Statins AE

A

Hepatotoxicity

Myopathy (increase with fibrates and niacin)

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5
Q

Lipid lowering agent that decreases mortality in CAD patients

A

Statins

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6
Q

Fibrates:

A

Gemfibrozil, Clofibrate, bezafibrate, fenofibrate

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7
Q

Fibrates MOA

A

Activates PPAR-a (HDL synthesis)

Upregulates LPL

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8
Q

Fibrates lipid effects

A

Decrease LDL

Decrease TAG

Increase HDL

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9
Q

Fibrates toxicity

A

Myopathy (increase with statins)

Gallstones

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10
Q

Niacin MOA

A

Decrease FA release (by inhibiting HSL)

Decrease VLDL synthesis

Decrease HDL clearance

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11
Q

Niacin lipid effects

A

Decrease LDL

Decrease TAG

Increase HDL

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12
Q

Niacin toxicity

A

Flushing and pruritis (stop with NSAIDs)

Hyperglycemia (acanthosis)

Hyperuricemia (gout)

Hepatotoxicity

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13
Q

Bile acid resins:

A

cholestyramine, cholestipol, cholesevelam

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14
Q

Bile acid resin MOA

A

Bind bile in intestines, prevent absorption in ileum

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15
Q

Bile acid resin lipid effects

A

Decrease LDL

Increase TAG

Increase HDL

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16
Q

bile acid resin toxicity

A

Nausea, bloating, cramps

Decreased absorption of other drugs and fat-soluble vitamins

17
Q

Ezetemibe MOA

A

Prevent cholesterol absorption in small intestine

18
Q

Ezetimibe lipid effects

A

Deceased LDL

19
Q

Ezetimibe toxicity

A

Diarrhea

Hepatotoxicity with statins

20
Q

Omega-3-FA MOA

A

Decrease TAG synthesis

21
Q

Omega-3-FA lipid effects

A

Decrease TAG

22
Q

Omega-3-FA toxicity

A

Nausea

DRUGS (41 decks)

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