Neuro - Alzheimers, huntingtons, migraine Flashcards
1
Q
Memantine (mech , tox)
A
Alzheimers:
Mech: NMDA receptor antagonist; helps prevent excitodocity mediated by Ca++
Tox: dizziness, confusion, hallucinations
2
Q
Donepizil, Galantamine, Rivastigmine, Tacrine
A
Alzheimers:
Mech: AChE inhibitors
Tox: nausea, dizziness, insomnia
3
Q
Tetrabenazine and reserpine
A
Huntingtons:
Mech: VMAT inhibitors; limit dopamine vesicle packageing and release
4
Q
Haloperidol
A
Huntingtons
D2 Receptor antagonist
5
Q
Triptans (sumotriptan) mech
A
5Ht 1B/1D agonist.
Inhibit trigeminal nerve activation; prevent vasoactive peptide release; induce vasoconstriction
6
Q
Triptans (sumotriptan) use
A
Acute migraine, cluster headaches
7
Q
Triptans (sumotriptan) AE
A
Coronary vasospasm (contrainindicated in patients with CAD or Prinzmetal angina)
Mild paresthesia
