ENDO - Signaling pathways Flashcards

1
Q

LH

A

cAMP

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2
Q

GHRH

A

cAMP

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3
Q

Thrombopoetin

A

RTK-associated - JAK/STAT

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4
Q

FSH

A

cAMP

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5
Q

Prolactin

A

RTK-associated - JAK/STAT

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6
Q

Ang-II

A

IP3

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7
Q

Oxytocin

A

IP3

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8
Q

EGF

A

Intrinsic tyrosin kinase - MAPK

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9
Q

GH

A

RTK-associated - JAK/STAT

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10
Q

Immunomodulators (IL-2, IL-6, IFN)

A

RTK-associated - JAK/STAT

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11
Q

ACTH

A

cAMP

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12
Q

RTK-associated signal via:

A

JAK/STAT - cytokines (and prolactin)

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13
Q

H1

A

IP3

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14
Q

Intracellulars

A

E, P, T T3/T4, cortisol, aldosterone, Vit D

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15
Q

Gastrin

A

IP3

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16
Q

Intrinsic tyrosin kinase signal via

A

MAPK - growth

17
Q

ADH-V1

A

IP3

18
Q

PTH

A

cAMP

19
Q

calcitonin

A

cAMP

20
Q

IGF-1

A

Intrinsic tyrosin kinase - MAPK

21
Q

hCG

A

cAMP

22
Q

TSH

A

cAMP

23
Q

ANP

A

cGMP

24
Q

TRH

A

IP3

25
Q

G-CSF

A

RTK-associated - JAK/STAT

26
Q

CRH

A

cAMP

27
Q

Erythropoetin

A

RTK-associated - JAK/STAT

28
Q

Insulin

A

Intrinsic tyrosin kinase - MAPK

29
Q

BNP

A

cGMP

30
Q

MSH

A

cAMP

31
Q

PDGF

A

Intrinsic tyrosin kinase - MAPK

32
Q

GnRH

A

IP3

33
Q

FGF

A

Intrinsic tyrosin kinase - MAPK

34
Q

ADH-V2

A

cAMP

35
Q

Glucagon

A

cAMP

36
Q

NO (EDRF)

A

cGMP

37
Q

Exceptions to the H = cAMP rule

[THESE ARE IP3]

A

GnRH

TRH

ADH-V1

(Histamine)