Nervous tissue

Question 1

Lewy bodies are

Answer 1

Cytoplasmic inclusions of degenerating neurons of the Substantia Nigra, Pars compacta, evident in patients with Parkinson’s disease and in cortical and brain-stem neurons in patients with certain forms of dementia

Question 2

Negri bodies are

Answer 2

Eosinophilic cytoplasmic inclusions seen in degenerating neurons in the hippocampus and cerebellar cortex in patients with rabies

Question 3

Tau Protein issues

Answer 3

Becomes excessively phosphorylated and prevents crosslinking of microtubules causing neurofibrillary tangles seen in Alzheimer’s disease, ALS, and Down Syndrome

Question 4

Axon cytoplasm contains only

Answer 4

Mitochondria and smooth ER

Question 5

What is transported via slow anterograde transport

Answer 5

1. Soluble cytoplasmic components
2. Cytoskeletal proteins
3. Enzymes
4. Precurors of small molecule NT

Question 6

Astrocytes remove

Answer 6

Glutamate and K ions from the extracellular space

Question 7

Only CN or SN affected in MS and why

Answer 7

Optic N because it is the only N formed by oligodendrocytes

Question 8

MS target

Answer 8

Oligodendrocytes

Question 9

Guillian-Barre target

Answer 9

Schwann cells

Question 10

Blood brain barrier consists of

Answer 10

1. Capillary endothelila cells
2. Basal lamina
3. Astrocytes
4. Pericytes