Connective Tissue Flashcards
CT support cells include
- Fibroblasts
- Myofibroblasts
- Chondroblasts
- Osteoblasts
- Adipocytes
What cells are CRUCIAL in response to injurty
Fibroblasts
What is the role of Myofibroblasts
Due to the fact that it contains actin microfilaments, critical in reshaping tissue as it reparis after injury
Kupffer cells
Macrophages of liver
What type of collagen leaves into extracellular space
Procollagen
Scurvy patho
Vit C deficiency causes reduced hydroxylation of selected prolines and lysines from Pro-α-chain
Osteogenesis Imperfecta patho
Collagen gene mutation so that there is no formation of Collagen
Ehlers-Danlos patho
Collagen and lysine hydroxylase gene mutaiton
Menkes Disease patho
Dificient cross-linking due to Cu deficiency because Cu is required by lysyl oxidase
Menkes Disease clinical
- Depigmented hair
- Arterial tortuosity, ruputre
- Cerebral degeneration
- Osteoporosis, anemia
Type I collagen found in
- Skin
- Tendon
- Ligaments
- Bone
- Cornea
Type II collagen found in
- Cartilage
- Intervertebral discs
- Vitreous body of the eye
Type III collagen found in
Blood vessels
Forms reticular fibers in various organs and tissues
First collagen synthesized in wound healing and then replaced by Type I collagen
Where is loose irregular CT found
Submucosa of many organs
Papillary dermis of skin
Elastic fibers composed of
Elastin and fibrillin
