Cartilage and bone Flashcards
Cartilage ECM Is rich with
Type II collagen fibrils and GAGs
Hyaline cartilage is
- Forms a template for bone formation during embryogenesis
- Articular cartilage on the surface of bones at synovial joints
- Cartilage of the nose, portions of the laynx, trachea, and Bronchi
Hyaline cartilage is rich in
- Hyaluronic acid
- Chondroitin sulfate
- Keratan sulfate
- High water content (resists compression)
Elastic cartilage found in
- External Ear
- Auditory Canal
- Epiglottis of the Larynx
Fibrocartilage features
Has type I collagen in addition to type II collagen making it very resistant to being streched
Fibrocartilage found in
Intervertebral disks
Menisci of the knee
Attachment of ligaments and tendons to bone
Hydroxyapatite
Crystalline strucutre that is comprised of Calcium and Phosphate ions
Osteoclasts responsible for
Breaking down bone matrix and releasing Calcium
Howship’s Lacuna is
The space carved out of bone by an osteoclast
Osteoclast activity is regulated by
Calcitonin and Vit D3
Intramembranous bone formation
Primitive mesenchyme can give rise directly to bone
Endochondral bone formation
Bone is formed on the template of preexisiting hyaline cartilage
Diaphysis
Center of the shaft of a long bone
Where endochondral ossification begins
The Reserve zone of bone growth
Consists of chondrocytes at the epiphyseal end of the growth plate
The proliferating zone of bone growth
Deep to the reserve zone and consists of proliferating chondrocytes that form clones aligned in columns parallel to the long axis of the bone
The zone of hypertrophy of bone growth
consits of chondrocytes deep to the proliferating zone that undergo hypertrophy by becoming larger and producing type 10 collagen and growth factors
Cortical/lamellar bone consists of
- Periosteum
- Outer circumferential lamellae
- Osteons
- Inner circumferential lamellae
- Spongy bone
- Endosteum
Osteon is
A Haversian canal with its surrounding lamellae constituents and forms the basic unit of mature lamellar bone
Volkmann’s canals are
Blood vessel canals that are perpendicular to Haversian canals.
Lack surrounding osteon
