Cerebellum and Basal Ganglia Flashcards
Balace and eye movement controlled by
Flocculonodular lobe
Major input to cerebellum travel via
Inferior cerebellar peduncle and middle cerebellar peduncle
Major outflow of cerebellum travel via
Superior cerebellar peduncle
What are the three cell layers of the cortex of the cerebellum
Molecular layer
Purkinje layer
Granule cell layer
Climbing fibers originate from
Inferior olivary complex of nuclei on the contralateral side of the medulla
Hemisphere lesion of cerebellum leads to
Ipsilateral symptoms:
- Intention tremor
- Dysmetria
- Dysdiadochokinesia
- Scanning dysarthria
- Nystagmus
- Hypotonia
Vermal lesions of cerebellum lead to
Truncal ataxia
Major components of Basal Ganglia
- Striatum
- External and internal segments of Globus Pallidus
- Substantia nigra
- Subthalamic nucleus
Net effect of disinhibition in the direct pathway results in
Increased level of cortical excitation and promotion of movement
Net effect of disinhibition in the indirect pathway results in
A decreased level of cortical excitation and suppression of unwanted movement
Parkinson disease chx
- Loss of pigmented dopaminergic neurons from Substantia nigra
- Lew bodies
Lewy bodies are
intracytoplasmic eosinophilic inclusions that contain α-synuclein
Huntington disease due to
AD degeneration of GABAergic neurons in neostriatum causing atrophy of caudate nucleus
It is due to unstable nucleotide repeat on Chr 4
Wilson disease clinical manifestation
- Tremor
- Asterixis
- Parkinsonian symptoms
- Chorea
- neurpsychiatric symptoms
- fatty change
- Hepatitis
- Wing beating tremors
Wilson disease treatment
Penicillamine
