Neoplasia Flashcards
What categories can neoplasms be broken into?
Benign and malignant
Characteristics of a benign neoplasm
Uncontrolled, slow growth of cells that are differentiated, non invasive
Characteristics of a malignant neoplasm
Disorderly, rapid undifferentiated growth that does not stop. Cancerous. It kills local tissue to make space for itself, very invasive
What is cancer due to?
Mutated genes
Which gene is defective in most cancers?
TP53 gene
What does the TP53 gene do?
Causes apoptosis when DNA is damaged
What do DNA repair genes do?
“Spell check” by fixing incorrect DNA sequence, detect and fix altered genes
What do Proto Oncogenes do?
They increase cell division
What happens if the Proto oncogene is mutated?
Uncontrolled cell division occurs leading to increased tissue growth
What does the tumor suppressor gene do?
Stops cell division and decrease cell growth
What happens if the tumor suppressor gene is mutated?
Cell division is uninhibited and there is an increase in tissue/cell growth
What is an oncogene?
Causes malignant or cancerous growth
What is the suffix for a benign tumor?
OMA
What is the suffix for a malignant tumor in epithelium and mesenchyme?
Carcinoma in epithelium and sarcoma in mesenchyme
How big does a tunic have to be in order to be clinically detectable?
1 cm