Myasthena Gravis Flashcards

1
Q

What does myasthenia gravis affect

A

Communication between the motor neuron and the inner cared muscle cells

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2
Q

What is the etiology of myasthenia gravis?

A

Autoimmunity with an unknown trigger

Possible sensitized T cells

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3
Q

What is the patho of myasthenia gravis?

A

Autoimmunity abs target acetylcholine receptors and bind to them -> less acetylcholine is binding -> muscle weakness and weakened contractions due to less acetylcholine actions

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4
Q

Many people with myasthenia gravis also have an abnormal what?

A

Thymus due to hyperplasia or tumor (large thymus)

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5
Q

How is myasthenia gravis diagnosed?

A
Hx
Px
Anticholinesterase test 
Nerve stimulation
Assay for ach receptor antibodies
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6
Q

How is myasthenia gravis treated?

A

Reversible anticholinesterase drugs
Immunosuppressive therapy
Plasmapheresis

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7
Q

What is the myasthenic crisis?

A

Sudden worsening of symptoms and weakness severe enough to compromise ventilation

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8
Q

When does the myasthenic crisis usually occur?

A

During a period of stress

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9
Q

What are mnft of myasthenia gravis ?

A

Eye muscle weakness
Unstable gait
Difficulty speaking (dysarthria)
Weakness in arms hands legs fingers and neck

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10
Q

What is myasthenia gravis?

A

Autoimmune disorder affecting transmission at neuromuscular junction

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