Guillain-Barre Syndrome Flashcards

1
Q

Where is the autoimmunity targeting in GB syndrome?

A

The PNS

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2
Q

Does GB usually go away?

A

Yes within around 6-12 months. That is why it is not tradition autoimmunity because traditional autoimmunity is lifelong

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3
Q

What is the etiology of GB syndrome?

A

Idiopathic - truly autoimmune but not of the traditional type

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4
Q

What GB preceded by about 1-4 weeks before autoimmunity starts?

A

Preceded by URT (viral infection usually EBV) or GI (bacterial infection usually compylobacter jejuni)

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5
Q

What is the patho of GB syndrome?

A

Abs and T cells target myelin sheaths in PNS -> damage of Schwann cells -> inflammation and damage -> loss of conduction

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6
Q

What are the manifestation of GB syndrome?

A

Signs of infection from URT or GI (if still present when autoimmunity starts)
Parasthesias (numbness and tingling) that turns into muscle weakness and then paralysis

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7
Q

What is unique about the progression of manifestations of GB syndrome?

A

The parasthesias start in the feet and then move in ascending order up the body. When the manifestations begin to go away they go away in descending order.

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8
Q

When parasthesias from GB syndrome pass either the hips or shoulders what is experienced?

A

Deep muscle pain

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9
Q

What is the main cause of death from GB syndrome?

A

Respiratory failure

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10
Q

How is GB syndrome diagnosed?(4)

A

Hx
Px (neuro & musculoskeletal exam to determine whether it is a neural, muscular or neuromuscular issue)
Weak tendon reflexes
Decreased nerve conduction
CSF analysis - slightly elevated proteins as innervation for PNS is at spinal cord

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11
Q

What is the treatment for GB syndrome?(4)

A

Preserve life
Plasmapheresis
IV IgG (immunoglobulins)
Pain meds

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12
Q

What is GB syndrome?

A

Untraditional autoimmunity that results in general paralysis

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