Cardiovascular Disease Flashcards
What is Hyperlipidemia?
Increased cholesterol, phospholipids, and triglyceride levels in blood
How are lipids transported in the blood?
Apoproteins
What is a lipoprotein?
Apoprotein-lipid complex
What are the different lipid densities?
LDL
VLDL
HDL
Which lipids don’t you want in your blood?
LDL
VLDL
Which lipids are good lipids?
HDL
How are lipids transported into the blood through the intestinal tract?
Cholymicrons
What is atherosclerosis?
Atheroma that forms in the intima of a larger blood vessel wall
What is an atheroma?
Fibrofatty tissue
What does atherosclerosis result in?
Hypoperfusion (ischemia) of tissues
What is an infarction and what is it a result from?
Cell death due to ischemia
What are the three stages of a lesion in atherosclerosis?
Fatty streak
Fibrous atheromatous plaque
Complicated lesion
What is the “fatty streak” stage of a lesion?
Cells and lipids are deposited in the vessel wall resulting in discolouration. Change only occurs in blood vessel wall. There is still 90% patency of BV
Describe the “fibrous atheromatous plaque” stage
Further deposition of cells (macrophage and platelets) lipids, fibres and smooth muscle cells. Change still only occurs in the vessel wall. 40%-50% compromise
Describe “complicated lesion” stage
This stage triggers an MI, stroke. Change occurs in the lumen of the BV. The thrombus can be dislodged and travel elsewhere in the body and cause a blockage.