Diabetes Insipidus Flashcards

1
Q

What issue occurs that results in DI?

A

Deficiency/decreased response to ADH

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2
Q

In Nephrogenic DI what occurs?

A

The kidneys do not respond to ADH

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3
Q

What are some reasons why the kidneys in Nephrogenic DI are not responsive to ADH?

A

Genetic trait affecting the V2 receptor that affects ADH receptor on the distal tubule
Drugs like lithium
Electrolyte imbalances

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4
Q

In central DI, what two subcategories are there?

A

Partial - insifficient amount of ADH

Complete - no ADH at all

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5
Q

In central DI what is the issue that brings about DI?

A

A defect in the synthesis or release of ADH

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6
Q

What are things that may cause central DI?

A

Head injury

Or surgery near the hypothalamus or posterior pituitary

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7
Q

What is the patho for central DI?

A

Loss of 80-90% of ADH secreting neurons -> polyuria

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8
Q

What are mnft of DI?

A

Polyuria

Excessive thirst

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9
Q

Which type of DI can maintain near normal water balance if they gave access to water when thirsty?

A

Partial Cdi

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10
Q

How is DI diagnosed?

A

24 hour output
MRI
measurement of ADH serum levels

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11
Q

What is the treatment for DI?

A

Thiazide diuretics

Desmopressin acetate

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12
Q

What two types of DI are there?

A

Neurogenic/central

Nephrogenic

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