Myocardial Infarction Flashcards
What happens in MI?
An MI is when there has been compromised blood flow to the myocardial tissue that leads to cell death.
In a MI, The heart’s myocardial tissue layer dies from decreased blood flow due to what causes:
Blockage in the coronary artery from coronary artery disease (most common)
Coronary spasms from illicit drug usage drugs like cocaine or hypertension. This causes constriction of the coronary artery and stops blood flowing to the heart muscle.
Damage to the coronary artery due to coronary artery dissection. This is a tear in the inner layer “tunica intima” of the artery which causes blood to leak in the “tunica media”. This restricts the flow of blood through the coronary artery. It can happen spontaneously and occurs more likely in young, active women.
Blockages in the _________________-coronary arteries can cause the worst damage from a myocardial infarction
Why is this ?
left
This is because blockages in the left coronary artery can cause anterior wall death which affects the left ventricle. Anterior MIs affect the most myocardial tissue, especially if the blockage occurs before it branches off and this can extend into the septum and lateral wall.
supplies right and left ventricle and septum. This is the most common site for blockages.
Left anterior descending artery
supplies the left atrium and ventricle
left circumflex
supplies the right
atrium and ventricle
Right coronary artery
supplies the right ventricle and septum
right marginal artery
What happens to the heart muscle after a MI?
When a coronary artery becomes 100% blocked the muscle cells die. Cell death is irreversible after about 30 minute. The cells are gone forever and can never be replaced.
Myocardial cell death is irreversible after about __________ minutes
30 minutes
What are early signs of an MI?
no physical changes to heart muscle yet (until about 6-8 hours), but when the myocytes die cardiac enzymes are released: CK-MB (4 to 6 hours after MI), troponin (2-4 hours…most regarded) myoglobin (1 hours after injury…show injury but not too specific).
Within ________________ hours inflammation sets in and _______________- come on the scene and congregate at the damaged tissue site. This causes complication of possible _________________. In addition, within 24 hours the heart fails to __________efficiently (cardiogenic shock) and ______________ can develop (atrial and ventricular dysrhythmia along with AV blocks).
24-36; neutrophils; pericarditis; pump; arrthymias
Within 10 days, _______________occurs when the macrophages come on the scene. They are WBCs who’ve come to clean up the dead cells and other components. However, the new tissue formed from granulation is not well formed and is ______________. This increases the chance of cardiac ____________.
granulation; weak ; rupture
Within __________ months scarring occurs, and the heart is affected in size and functionality due to increased collagen.
2 months
other complications of MI
Heart failure, depression, and ventricular aneurysm
signs & symptoms of MI : mnemonic CRUSHING
Chest pain (intense, heavy)
Radiating chest pain that goes to left arm, jaw, back
Unrelieved by nitroglycerin or rest (chest pain)
Sweating (cold)
Hard to breathe (shortness of breath)
Increased heart rate, blood pressure or irregular heart rate
Nausea with vomiting
Going to be anxious and scared