Muscles Lectures Flashcards
What causes the force of a contraction to be stronger than the one before it in wave summation?
The tautness of the elastic components and the partially contracted state of filaments
define tropomyosin
a component of thin filament; when skeletal muscle is relaxed, tropomyosin covers myosin-binding sites on actin molecules which prevents myosin from binding to actin
define isometric contractions
Muscle length does not change. Think of this as holding a position with a muscle.
What are the steps of contraction in smooth muscle
- Ca2+ enters the cell from the interstitial fluid or is released by the sarcoplasmic reticulum
- Ca2+ binds to calmodulin
- Calmodulin activates myosin light chain kinase
- MLCK uses ATP to add a phosphate group to a portion of the myosin head
- Once the phosphate group is attached the myosin head can attach to actin and contraction can occur
What are the two arrangements of smooth muscle?
single-unit and multi-unit
What is fascicular arrangement correlated with?
the amount of power a muscle can produce
the range of motion a muscle can produce
What are the two types of contractile proteins?
myosin and actin
Fibers can generate considerable ATP by aerobic cellular respiration, which gives them a moderately high resistance to fatigue are ———————–
fast oxidative glycolytic fibers
define H zone
narrow region in center of each A band that contains thick filaments and no thin filaments
what is the muscle version of cytoplasm
sarcoplasm
What partially accounts for the slow onset of contraction of smooth muscle?
The lack of transverse tubules makes it slower for Ca2+ to reach the filaments
Pair the connective tissue types (endomysium, perimysium, epimysium) with the type of muscle it goes with
Skeletal muscle: all three
cardiac muscle: no epimysium
smooth muscle: only endomysium
What is the location, function, appearance, and control of skeletal muscle?
location: skeletal
function: move bones
appearance: multinucleated and striated
control: voluntary
What is compartment syndrome?
pressure constricts structures within a compartment resulting in damage to blood vessels. If left untreated it can lead to nerve damage and muscle scar tissue and contracture
50% of muscle fibers in skeletal muscle are this type of fiber
slow oxidative
define z disc
narrow, plate shaped regions of dense material that separate one sarcomere from the next
What are the two muscles of mastication?
masseter and temporalis
The force of a muscle contraction depends on the ——— in a muscle prior to contraction
length of the sarcomeres
When does wave summation occur?
When a second action potential triggers muscle contraction before the first contraction has finished. It results in a stronger contraction.
Long cylindrical cell covered by endomysium and sarcolemma called
muscle cell
What makes stretching more effective?
increasing the temperature of the tissue
The basic functional units of myofibrils is
sarcomere
What is the location, function, appearance, and control of smooth muscle?
location: various organs
function: various including peristalsis
appearance: one nucleus and nonstriated
control: involuntary
Define fascia
a dense sheet or broad band of irregular connective tissue
The two types of cardiac enlargements are
physiological and pathological
Define epimysium
dense, irregular, connective tissue, encircling the entire muscle
What causes plantar fasciitis?
chronic irritation of the plantar aponeurosis at its origin on the calcaneus.
What is central fatigue?
A sudden feeling of tiredness and desire to cease activity caused by changes in the central nervous system. Thought to be protective.
What is hypertrophy caused by?
increased synthesis of thick and thin filaments
A nerve impulse (nerve action potential) elicits a muscle action potential in the following three ways
release acetylcholine
activation of acetylcholine receptors
production of muscle action potential
What can smooth muscle sustain?
long-term tone which maintains a steady pressure on the contents within the organ or vessel (blood pressure and arterioles)
Define myosin
Makes up the thick filament in the sarcomere. Consists of a tail and two myosin heads, which bind to myosin-binding sites on actin.
What are the structural proteins?
titin, alpha actinin, myomesin, nebulin, and dystrophin
What is tone?
A small amount of tension in the muscle even at rest. Established by alternating, involuntary activation of small groups of motor units in a muscle.
What do most running injuries involve?
the knee
A single somatic motor neuron makes contact with an average of 150 skeletal muscle fibers, and all of the muscle fibers in one motor unit contract in a term called
unison
What is the lever (bone) acted on by?
resistance and effort
Give a brief explanation of the creatine phosphate cycle
When contraction begins and the ADP level starts to rise, creatine kinase catalyzes the transfer of a high-energy phosphate group from creatine phosphate back to ADP. This direct phosphorylation reaction quickly generates new ATP molecules. Since the formation of ATP from creatine phosphate occurs very rapidly, creatine phosphate is the first source of energy when muscle contraction begins.
More:
While muscle fibers are relaxed, they produce more ATP than they need for resting metabolism. Most of the excess ATP is used to synthesize creatine phosphate (KRĒ-a-tēn), an energy-rich molecule that is found in muscle fibers (Figure 10.11a). The enzyme creatine kinase (CK) catalyzes the transfer of one of the high-energy phosphate groups from ATP to creatine, forming creatine phosphate and ADP. Creatine is a small, amino acid–like molecule that is synthesized in the liver, kidneys, and pancreas and then transported to muscle fibers. Creatine phosphate is three to six times more plentiful than ATP in the sarcoplasm of a relaxed muscle fiber. When contraction begins and the ADP level starts to rise, CK catalyzes the transfer of a high-energy phosphate group from creatine phosphate back to ADP. This direct phosphorylation reaction quickly generates new ATP molecules. Since the formation of ATP from creatine phosphate occurs very rapidly, creatine phosphate is the first source of energy when muscle contraction begins. The other energy-generating mechanisms in a muscle fiber (the pathways of anaerobic glycolysis and aerobic respiration) take a longer period of time to produce ATP compared to creatine phosphate. Together, stores of creatine phosphate and ATP provide enough energy for muscles to contract maximally for about 15 seconds.
What are anabolic steroids?
synthetic variations of testosterone that increase muscle size and strength
define M line
region in the center of the H zone that contains proteins that hold thick filaments together at center of sarcomere.
What are the two sources of oxygen for muscle tissue?
- oxygen that diffuses into muscle fibers from the blood
2. oxygen released by myoglobin within muscle fibers.
what are three factors that affect maximum tension?
amount of stretch before contraction and nutrient and oxygen availabilty
A narrow ——————- zone in the center of each A band contains thick but not thin filaments.
H
The ability of muscular tissue to contract forcefully when stimulated by an action potential is called
contractility
what is the latent period?
the action potential sweeps over the sarcolemma, and the calcium ions are released from the sarcoplasmic reticulum.
What are the unique structural features of smooth muscle?
no sarcomeres intermediate filaments no striations no transverse tubules caveolae cavus for extracellular Ca2+ dense bodies twists as it contracts
define nebulin
wraps around entire length of each thin filament, helps anchor thin filaments to Z discs and regulates length of thin filaments during development
An increase in the number of muscle fibers called
hyperplasia
define endomysium
Made of RETICULAR connective tissue, separates individual muscle fibers from one another.
What are the four phases of twitch contraction?
latent, contraction, relaxation, and refractory
What is unfused tetanus?
A skeletal fiber is stimulated at a rate of 20-30 times per second and can only partially relax between stimuli.
The functions of the fascia are
allows free movement of muscles
fills spaces between muscles
What will happen if two stimuli are applied immediately after the other?
the muscle will only respond to the first one
what is the primary function of slow oxidative fibers?
maintaining posture and aerobic endurance activities
how can running injuries be treated?
price, nsaids, steroid injections, and rehab
what is the primary function of fast glycolytic fibers?
rapid, intense movements of short duration
What influences the proportions of types of skeletal muscle fibers in a muscle?
- action of muscle
- person’s exercise routine
- genetics
There are small pouch-like invaginations of the plasma membrane in the smooth muscles called ———————————————– that contain extracellular calcium
caveolae
The neurons that stimulate a skeletal muscle to contract called
somatic motor neurons
Muscular tissue contributes to homeostasis by
body movements
moving substances
producing heat
define actin
The main component of thin filaments. Has a myosin-binding site where myosin head binds during muscle contraction
define titin
structural protein that connects Z discs to M line of sarcomere. Stabilizes thick filament position, and creates the elasticity and extensibility of myofibrils.
List the organizations of tissues in muscles starting from the largest and going to the smallest
skeletal muscle->fascicle->muscle fiber (cell)->myofibril->sarcomere->filaments
Supporting protein in the middle of the sarcomere forming the ——- line
M line
What is the total force/tension a single muscle fiber can produce dependent on?
the rate at which nerve impulses arrive at the NMJ
Explain the contraction cycle
Before step 1
calcium binds to troponin moving tropomyosin off the binding sites
What are the three muscle types in a muscle group and what are their definitions
- agonist/prime mover: a muscle that contracts to cause an action
- antagonist: stretches and yields to the prime mover and does the opposite action
- synergists: contract and stabilize intermediate joints when a prime mover crosses more than one joint. supports the movement of the prime mover
Describe how the muscle contraction spreads from the sarcomere to the bones
sarcomeres contract, which pulls on dystrophin which is connected to the sarcolemma, which causes the sarcolemma to move, which then causes the entire cell to contract, the more cells that contract the stronger contraction is in the muscle. That contraction of the muscle pulls on tendons which pull on bones and cause movement.