Muscle Clinical Pathology Flashcards
what does creatine kinase (CK) do?
converts creatine to creatine phosphate and reverse
what is creatine kinase composed of?
2 brain (B) or muscle (M) subunits
where is CK-MM found?
skeletal and cardiac muscle
when might increased serum AST occur?
hemolysis
hepatocellular damage
muscle necrosis/degeneration
what can severe muscle necrosis cause with bicarbonate?
can artifactually increase measured serum bicarbonate
when does creatine kinase peak?
6-12 hours
after a single myopathic event, how quickly does creatine kinase increase?
rapidly
returns to normal in 1-3 days
what are the cardiac muscle biomarkers?
CK-MB
pro-BNP
troponin
LDH
where is most troponin found?
myofibrils
some free in cytoplasm
where is myoglobin usually assessed?
in urine: reacts like blood or hemoprotein
what is hematuria?
red blood cells in urine sediment
clears with centrifugation
