Module 6.2 and 6.3 Fluid and Acid-Base Balance Flashcards

1
Q

The fluids in the body are located in the __________ and ________ compartments

A

The fluids in the body are located in the intracellular fluid (ICF) and extracellular fluid (ECF) compartments

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2
Q

The ECF includes

  • _______,
  • _______
  • _______
  • _______
A

The ECF includes

  • plasma,
  • interstitial fluid,
  • lymph, and
  • transcellular fluids.
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3
Q

Fill in the values on the table

A
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4
Q

Because of the presence of different barriers between the fluid compartments of the body, the ionic composition of each differs.

For example, the _________walls serve as the barrier between the plasma and ISF, and the _____ ____\_ of the cells forms the barrier between the ECF and ICF.

A

Because of the presence of different barriers between the fluid compartments of the body, the ionic composition of each differs.

For example, the blood vessel walls serve as the barrier between the plasma and ISF, and the plasma membrane of the cells forms the barrier between the ECF and ICF.

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5
Q

The following diagram outlines the major ionic differences between the plasma, ISF, and ICF.

Based on the ionic differences, decide which is plasma, which is ISF and which is ICF

A
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6
Q

Fluid balance in the body is dependent upon ___\_and ____\_ balance.

A

Fluid balance in the body is dependent upon salt and water balance.

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7
Q

Regulation of fluid balance occurs through regulation of _____\_and ______\_

A

Regulation of fluid balance occurs through regulation of ECF volume and osmolarity

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8
Q

Maintenance of ECF volume is important for maintenance of _______ _______ and is dependent upon ____ balance

A

Maintenance of ECF volume is important for maintenance of blood pressure and is dependent upon salt balance

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9
Q

Maintenance of ECF osmolarity is important for the maintenance of _______ and is dependent upon _______

A

Maintenance of ECF osmolarity is important for the maintenance of an isotonic cellular environment and is dependent upon water balance

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10
Q

Salt input occurs only through _______, and salt output occurs through _______ and _______loss

A

Salt input occurs only through ingestion, and salt output occurs through perspiration and urinary and fecal loss

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11
Q

Complete the table for the daily balance of salt input/output

A
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12
Q

Salt balance is regulated only by the kidneys through urinary loss

A

Salt balance is regulated only by the kidneys through urinary loss

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13
Q

Conservation or excretion of salt is achieved through regulation of both the _______ and the _______ of _______

A

Conservation or excretion of salt is achieved through regulation of both the glomerular filtration rate (GFR) and the tubular reabsorption of sodium (Na+)

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14
Q

Explain the image:

The effects of decreased blood pressure on renal handling of sodium (Na+):

  • Decreases in arterial blood pressure influence both the _______ and the secretion of _______.
  • As a result, sodium excretion is _______ and sodium conservation is _______, thus arterial blood pressure can be restored.
A

Explain the image:

The effects of decreased blood pressure on renal handling of sodium (Na+):

  • Decreases in arterial blood pressure influence both the glomerular filtration rate (GFR) and the secretion of aldosterone.
  • As a result, sodium excretion is decreased and sodium conservation is increased, thus arterial blood pressure can be restored.
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15
Q

Osmolarity is a measure of what?

A

Osmolarity is a measure of the concentration of individual solute particles dissolved in a fluid

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16
Q

A change in water balance that is not accompanied by a corresponding change in salt balance leads to changes in _______

A

A change in water balance that is not accompanied by a corresponding change in salt balance leads to changes in osmolarity

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17
Q
  • A deficit of water in the ECF, such as that associated with dehydration, results in a _______ cellular environment.
  • An excess of water in the ECF, such as that associated with overhydration, results in a _______ cellular environment.
A
  • A deficit of water in the ECF, such as that associated with dehydration, results in a hypertonic cellular environment.
  • An excess of water in the ECF, such as that associated with overhydration, results in a hypotonic cellular environment.
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18
Q

Explain the image:

Red blood cells in solutions of different tonicity:

  • The effects of isotonic (__\_), hypotonic (__\_) and hypertonic (__\_) solutions on a red blood cell.
  • In an _____\_ solution, the intracellular and extracellular water concentrations are the same and there is an equal and opposite movement of water across the membrane.
  • In a _____\_ solution, the extracellular water concentration is higher than the intracellular water concentration and there is a net movement of water into the cell causing the cell to swell.
  • In a _____\_ solution, the extracellular water concentration is lower than the intracellular water concentration and there is a net movement of water out of the cell causing the cell to shrink.
A

Explain the image:

Red blood cells in solutions of different tonicity:

  • The effects of isotonic (left), hypotonic (centre) and hypertonic (right) solutions on a red blood cell.
  • In an isotonic solution, the intracellular and extracellular water concentrations are the same and there is an equal and opposite movement of water across the membrane.
  • In a hypotonic solution, the extracellular water concentration is higher than the intracellular water concentration and there is a net movement of water into the cell causing the cell to swell.
  • In a hypertonic solution, the extracellular water concentration is lower than the intracellular water concentration and there is a net movement of water out of the cell causing the cell to shrink.
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19
Q

Hypertonicity (net water out) can result from

  • _______\_
  • _______\_
  • ________.
A

Hypertonicity (net water out) can result from

  • insufficient water intake,
  • excessive water loss, or
  • diabetes mellitus.
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20
Q

Someone with the following symptoms might be experiencing the effects of ________

  • neuronal changes resulting in altered mental functioning,
  • circulatory disturbances resulting in hypotension,
  • and anatomic changes, including dry skin, sunken eyeballs, and dry tongue
A

hypertonicity

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21
Q

Hypotonicity can result from

  • ________
  • ________ ___\_,
  • ________________
A

Hypotonicity can result from

  • renal failure,
  • inappropriate levels of vasopressin secretion,
  • or rapid ingestion of excessive quantities of water
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22
Q

Someone with the following symptoms might be experiencing the effects of ________:

  • neuronal changes resulting in altered mental functioning,
  • circulatory disturbances resulting in hypertension,
  • and muscle weakness.
A

Someone with the following symptoms might be experiencing the effects of hypotonicity:

  • neuronal changes resulting in altered mental functioning,
  • circulatory disturbances resulting in hypertension,
  • and muscle weakness.
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23
Q

Water input occurs through ________ and ________.

Water output occurs through ________, ________loss, and ________

A

Water input occurs through ingestion and metabolic production.

Water output occurs through perspiration, urinary and fecal loss, and insensible loss.

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24
Q

Insensible loss includes water output from the ________ (through ________) and from ________ (through ________)

A

Insensible loss includes water output from the lungs (through respiration) and from non-sweating skin (through evaporation)

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25
Fill in the table
26
Unlike salt balance, water balance is maintained by regulation of both ________ and \_\_\_\_\_\_\_\_
Unlike salt balance, water balance is maintained by regulation of both _input_ and _output_
27
* Input is regulated by \_\_\_\_\_\_\_\_, and is coordinated by the ________ of the \_\_\_\_\_\_\_\__._ * Output is regulated by ________ of water in the \_\_\_\_\_\_\_\_, which is mediated by the actions of the hormone \_\_\_\_\_\_\_\_. * *Regulation of water input and output occurs simultaneously*
* Input is regulated by _thirst_, and is coordinated by the _thirst centre_ of the _hypothalamus._ * Output is regulated by _tubular reabsorption_ of water in the _kidneys_, which is mediated by the actions of the hormone _vasopressin_. * *Regulation of water input and output occurs simultaneously*
28
Role of the hypothalamic neurons during a water (H2O) deficit flow chart:
29
In addition to the coordinated actions of ________ and \_\_\_\_\_, various other regulatory factors influence water balance
In addition to the coordinated actions of _vasopressin_ and _thirst_, various other regulatory factors influence water balance
30
Stressors such as \_\_\_\_\_, \_\_\_\_\_, or _____ increase vasopressin secretion, but do not influence thirst
Stressors such as _pain_, _fear_, or _trauma_ increase vasopressin secretion, but do not influence thirst
31
\_\_\_\_of the\_\_\_\_ stimulates thirst but does not influence vasopressin secretion
_Dryness of the oral cavity_ stimulates thirst but does not influence vasopressin secretion
32
Psychosocial factors, such as _____ and \_\_\_\_\_\_\_\_, also influence water input or output, irrespective of thirst or vasopressin secretion
Psychosocial factors, such as _habits_ and _social engagements_, also influence water input or output, irrespective of thirst or vasopressin secretion
33
Acid-base balance is achieved through the regulation of ____________ concentration in body fluids
Acid-base balance is achieved through the regulation of _hydrogen ion (H+)_ concentration in body fluids
34
The unit used to describe H+ concentration is \_\_\_\_\_, which is based on a logarithmic scale
The unit used to describe H+ concentration is _pH_, which is based on a logarithmic scale
35
A solution with a pH value less than 7 is \_\_\_\_\_, whereas a solution with a pH value greater than 7 is _____ or \_\_\_\_\_
A solution with a pH value less than 7 is _acidic_, whereas a solution with a pH value greater than 7 is _basic_ or _alkaline_
36
The H+ concentration of arterial blood is __________ regulated and is maintained within the pH range of ____ to \_\_\_\_
The H+ concentration of arterial blood is _homeostatically_ regulated and is maintained within the pH range of _7.35_ to _7.45_
37
Outside of the range of 7.35 to 7.45, there are changes in * the excitability of _____ and _____ cells, * in _____ conformation, and * in _____ balance, all of which interfere with normal cell functioning
Outside of the range of 7.35 to 7.45, there are changes in * _the excitability of neurons and muscle cells,_ * _in protein conformation, and_ * _in potassium (K+) balance,_ all of which interfere with normal cell functioning
38
The pH range compatible with life is pH _\_\_\__to _\_\_\_\_\__.
The pH range compatible with life is pH _6.8_ to _8.0_.
39
Chemical and physiological pH considerations: (Top) Relationship of pH to the relative concentrations of acid (H+) and base (OH-). (Bottom) The plasma pH range compatible with life is pH 6.8 – 8.0 and includes normal, acidic, and alkaline conditions within that range.
Chemical and physiological pH considerations: (Top) Relationship of pH to the relative concentrations of acid (H+) and base (OH-). (Bottom) The plasma pH range compatible with life is pH 6.8 – 8.0 and includes normal, acidic, and alkaline conditions within that range.
40
Acid-base balance is regulated through three lines of defence against changes in H+ concentration: * \_\_\_\_\_\_\_\_\_\_ * __________ and * \_\_\_\_\_\_\_\_\_\_
Acid-base balance is regulated through three lines of defence against changes in H+ concentration: * _chemical buffering,_ * _respiratory compensation, and_ * _renal compensation_
41
\_\_\_\_\_systems are always present, always available, and always being used, whereas _____ and _____ are feedback loops involving multiple steps and multiple body systems
_Chemical buffer_ systems are always present, always available, and always being used, whereas _respiratory compensation_ and _renal compensation_ are feedback loops involving multiple steps and multiple body systems
42
CHEMICAL BUFFERING SYSTEM Chemical buffering minimizes changes in pH by adding or removing a/n _____ or _____ from solution. Chemical buffering is the first line of defence and occurs within seconds.
Chemical buffering minimizes changes in pH by adding or removing an _acid_ or _base_ from solution. Chemical buffering is the first line of defence and occurs within seconds.
43
CHEMICAL BUFFERING SYSTEM Upon coming into contact with a \_\_\_\_\_\_\_\_\_\_, acids and bases spontaneously undergo the associated reactions; thus, this is the fastest defence against changes in pH.
Upon coming into contact with a _chemical buffer system_, acids and bases spontaneously undergo the associated reactions; thus, this is the fastest defence against changes in pH. The most important chemical buffer system in the **extracellular fluid (ECF)** is the __________ buffer pair, which can be described by what equation? The most important chemical buffer system in the extracellular fluid (ECF) is the _carbonic acid (H2CO3)-bicarbonate (HCO3–)_ buffer pair, which can be described by the equation. **H2CO3↔ HCO3– + H+**
44
CHEMICAL BUFFER SYSTEM **Intracellular fluid (ICF**) buffer systems include _\_\_\_\_\_\__, _\_\_\_\_\__, and _\_\_\_\_\_\__.
CHEMICAL BUFFER SYSTEM **Intracellular fluid (ICF**) buffer systems include _proteins_, _hemoglobin_, and _phosphates_.
45
CHEMICAL BUFFERING SYSTEM The most important chemical buffer system in the **extracellular fluid (ECF**) is the __________ buffer pair, which can be described by what equation?
The most important chemical buffer system in the extracellular fluid (ECF) is the _carbonic acid (H2CO3)-bicarbonate (HCO3–)_ buffer pair, which can be described by the equation: **H2CO3↔ HCO3– + H+**
46
RESPIRATORY COMPENSATION Respiratory compensation regulates pH through changes in _ventilation_.
Respiratory compensation regulates pH through changes in \_\_\_\_\_.
47
\_\_\_\_\_ _____ is the second line of defence and is activated within minutes.
_Respiratory compensation_ is the second line of defence and is activated within minutes.
48
RESPIRATORY COMPENSATION: Increases in ventilation decrease the plasma concentration of\_\_\_\_\_, which _____ the plasma concentration of H+, increasing plasma \_\_\_. Decreases in ventilation have the opposite effect.
Increases in ventilation decrease the plasma concentration of _carbon dioxide (CO2)_, which _decreases_ the plasma concentration of H+, increasing plasma _pH_. Decreases in ventilation have the opposite effect.
49
RESPIRATORY COMPENSATION The effect of CO2 on pH is mediated through the what equation?
The effect of CO2 on pH is mediated through the what equation? ## Footnote **CO2 + H2O ←--------------→ H2CO3 ↔HCO3– + H+**
50
Renal compensation regulates pH through changes to * _____ excretion * __________ excretion, and * __________ secretion in the urine
Renal compensation regulates pH through changes to * _H+_ excretion * _bicarbonate ion (HCO3–)_ excretion, and * _ammonium (NH4+)_ secretion in the urine
51
\_\_\_\_\_\_\_\_\_\_ is the third line of defence and is activated within hours to days of an acid-base imbalance.
_Renal compensation_ is the third line of defence and is activated within hours to days of an acid-base imbalance.
52
RENAL COMPENSATION A decrease in pH will result in _____ secretion of H+, increased reabsorption of \_\_\_\_\_, and increased synthesis of \_\_\_\_\_.
A decrease in pH will result in _increased_ secretion of H+, increased reabsorption of _Bicarbonate_ (_HCO3–)_, and increased synthesis of _HCO3–_.
53
Acid-base imbalances are categorized as 1. \_\_\_\_\_\_\_\_, 2. \_\_\_\_\_\_\_\_\_\_, 3. \_\_\_\_\_\_\_\_\_\_, and 4. \_\_\_\_\_\_\_\_\_\_.
Acid-base imbalances are categorized as 1. respiratory acidosis, 2. respiratory alkalosis, 3. metabolic acidosis, and 4. metabolic alkalosis.
54
Respiratory imbalances result from changes in _____ concentrations, whereas metabolic imbalances result from changes to _____ through means not related to _____ concentrations.
Respiratory imbalances result from changes in _CO2_ concentrations, whereas metabolic imbalances result from changes to _pH_ through means not related to _CO2_ concentrations.
55
**Respiratory acidosis** is due to increased plasma concentrations of _____ and is caused by \_\_\_\_\_\_\_.
**Respiratory acidosis** is due to increased plasma concentrations of _CO2_ and is caused by _hypoventilation_.
56
**Respiratory alkalosis** is due to decreased plasma concentrations of _____ and is caused by \_\_\_\_\_\_\_\_.
**Respiratory alkalosis** is due to decreased plasma concentrations of _CO2_ and is caused by _hyperventilation_
57
What two compensatory mechanisms are used to counteract respiratory acidosis and respiratory alkalosis?
Chemical Buffering Renal Compensation
58
**Metabolic acidosis** may result from * severe \_\_\_\_\_, * \_\_\_\_\_\_\_\_\_\_, * \_\_\_\_\_\_\_\_\_\_, or * \_\_\_\_\_\_\_\_\_\_.
**Metabolic acidosis** may result from * severe _diarrhoea_, * _diabetes mellitus_, * _strenuous exercise_, or * _uremic acidosis_.
59
**Metabolic alkalosis** may result from * excessive _____ or * ingestion of _____ \_\_\_.
**Metabolic alkalosis** may result from * excessive _vomiting_ or * ingestion of _alkaline drugs_.
60
What compensatory mechanisms are used to counteract metabolic imbalances in plasma pH (metabolic alkalosis and metabolic acidosis)?
* chemical buffering, * respiratory compensation * renal compensation