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MYCV > MIDTERM LEC TOPICS - ADENO, PARVO, PAPOVA > Flashcards

MIDTERM LEC TOPICS - ADENO, PARVO, PAPOVA Flashcards

1
Q

how many family of DNA viruses are there?

A

7 families

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2
Q

how many family of RNA viruses are there?

A

14 families

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3
Q

are adenovirus naked or with envelope

A

naked icosahedral

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4
Q

type of DNA of adenoviridae

A

linear double stranded DNA

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5
Q

size of adenoviridae

A

70-90 nm

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6
Q

adenoviridae is first isolated from cultures of

A

human adenoids and tonsils in 1950

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7
Q

the Only member of adenovirus cause human infection

A

Mastadenovirus

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8
Q

how many serotypes of human adenoviruses have been described currently?

A

52 serotypes

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9
Q

they infect wide range of host, animals, humans and birds

A

adenoviridae

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10
Q

what disease are the most common clinical manifestation associated with adenovirus infection

A

respiratory and gastrointestinal disease

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11
Q

adenoviridae infects infants and general population in how many percent?

A

18% of all acute acute diarrheal infection in infant
5% respiratory disease in general population

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12
Q

what serotypes of adenovirus can cause gastroenteritis in infant and young children,

A

serotypes 40 and 41

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13
Q

MOT of adenoviridae

A

aerosol/airborne

respiratory disease - respiratory secretions, stool, fomites

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14
Q

what is the incubation period for respiratory disease caused by adenoviridae

A

2-14 days

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15
Q

what are the common upper respiratory tract infections caused by adenovirus

A

colds, tonsilitis, pharyngitis, pharyngoconjunctival fever, and sometimes croup (viral infection of the larynx )

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16
Q

complications of respiratory disease caused by adenoviridae to infants

or ano ung possible secondary infection nito sa infant if may respiratory disease

A

eye and conjunctivitis often accompany respiratory disease

otitis media - often a complication to respiratory disease

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17
Q

describe the lower respiratory tract infection of adenoviridae

A

quite severe in children and the pneumonia is often fatal in infants and young children

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18
Q

what is the unique feature of adenovirus that causes epidemics in the military

A

it can cause severe and acute respiratory disease , often resulting in considerable morbidity and mortality

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19
Q

Adenoviruses can be detected from respiratory secretions or stool in cell culture using various epithelial cell lines such

A

A-549, Hep-2, and He-La cells –

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20
Q

describe the cytopathic effect appearance of adenovirus

A

Grape like cluster cytopathic effect

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21
Q

the viral capsid of adenoviridae has how many capsomere, hexons, and penton

A

252 capsomeres
240 hexons
12 pentons

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22
Q

adenovirus

the genome consist of linear double stranded DNA with a molecule of approx. __ kilo base pairs

A

26-45

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23
Q

adenoviridae is stable and viable for about _____

A

week at 37C but inactivated at 50C

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24
Q

adenoviridae are resistant to

A

ether and bile salts

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25
Q

tropism of adenoviridae

A

nucleus of epithelial cells

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26
Q

genus under adenoviridae

A

mastadenovirus
aviadenovirus

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27
Q

which one of the genus of adenoviridae infects birds

A

aviadenovirus

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28
Q

85 serotypes of human adenovirus is divided into how many species

A

7 species (A to G )

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29
Q

commonly causes respiratory and gastrointestinal disease but is also associated with conjuctivitis, keratitis, and disseminated multi-organ disease for immunocompromised patients

A

adenovirus

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30
Q

MOT of adenoviridae

A

respiratort
feco oral
fomites

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31
Q

incubation period for adenoviridar

A

2-14 days for respiratory
3-10 days for gastro

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32
Q

the major cause of nonbacterial pharyngitis and tonsillitis, presenting as febrile common cold.

A

adenovirus

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33
Q

Adenovirus types what are associated with
pneumonia in adults resembling primary atypical pneumonia

A

3 and 7

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34
Q

ADENOVIRIDAE

the cause of an acute respiratory
disease (ARD) syndrome among military recruits.

A

serotypes 4,7,21

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35
Q

adenoviridae

it tends to occur in outbreaks, such
as at children’s summer camps

A

Pharyngoconjunctival fever:

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36
Q

Pharyngoconjunctival fever is associated with what serotypes

A

3, 7, 14

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37
Q

adenoviridae

a serious condition which
may appear as an epidemics, usually caused by type 8 and less often by types 19 and 37

A

Epidemic keratoconjunctivitis (EKC)

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38
Q

this condition caused by adenoviridae that occurs mainly in adults and is highly contagious

A

Epidemic keratoconjunctivitis (EKC)

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39
Q

acute follicular conjunctivitis caused by adenovirus are caused by which serotypes

A

3, 4, 11

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40
Q

which conjunctivitis is adenovirus similar with?

A

chlamydial conjunctivitis

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41
Q

Some fastidious adenoviruses can cause diarrheal disease
in children (serotypes __and ___)

A

40 and 41

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42
Q

systemic infection caused by adenovirus serotype 3 and 7

A

meningitis

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43
Q

test that can be done in nose and throat swab in VTM for detecction of adenovirus

A

virus culture

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44
Q

test that can be done in bronchoalveolar lavage fluid for the detection of adenovirus

A

pcr

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45
Q

test that can be done in nasopharyngeal aspirates for the detection of adenovirus

A

immunofluorescence - takes less than 2 hrs

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46
Q

test that can be done in conjunctival swab in virus from VTM in detection of adenovirus

A

culture and PCR

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47
Q

test that can be done in feces in the detection of adenovirus

A

PCR
rapid test devices
electron microscopy

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48
Q

is there antiviral chemotherapy available for adenovirus infection

A

No specific antiviral chemotherapy (supportive care only)

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49
Q

treatment and prevention for adenovirus infection in pools

A

For swimming poo-associated conjunctivitis-adequate levels of
CHLORINE in water

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50
Q

do we have vaccines available for adenovirus

A

yes but only for military recruits

Non-attenuated live Adenovirus types 4, 7, and 21 packaged in enteric capsules (military only

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51
Q

AAVs means

A

(Adenovirus Associated Viruses)

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52
Q

(Adenovirus Associated Viruses) are members of

A

parvoviridae

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53
Q

these are dependent with adenoviruses or herpes simplex virus to provide missing functions

A

(Adenovirus Associated Viruses)

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54
Q
  • Smallest of the DNA viruses (~22nm
A

Parvoviridae

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55
Q

physical of parvoviridae

A
  • Small, non-enveloped icosahedral capsid
    Linear single stranded DNA genome
56
Q

2 subfamilies of parvoviridae

A

densovirinae
parvovirinae

57
Q

the subfamily of -parvoviridae that infects invertebrates (insects and crustaceans)

A

densovirinae

58
Q

the subfamily of -parvoviridae that infects vertebrates

A

parvovirinae

59
Q

3 important genus affecting humans of parvovirinae

A

dependoparvovirus
erythroparvovirus
bocaparvovirus

60
Q

genus of parvovirinae that is the canine parvovirus

A

faudovirus

61
Q

genus of parvovirinae that is a feline parvovirus

A

protoparvovirus

62
Q

genus of parvovirinae that is a porcine parvovirus

A

tetraparvovirus

63
Q

Characterized by their dependance on helper viruses such as
adenoviruses or herpesviruses for replication

A

Dependoparvovirus

64
Q

Adeno-associated viruses (AAV)
* Can cause ___ illness

A

mild respiratory

65
Q
  • Can be used in gene-replacement therapy because of its low
    immunogenicity and wide tissue tropism
A

Adeno-associated viruses (AAV)

66
Q

Associated with a variety of respiratory infections including
bronchiolitis, pneumonia, and upper respiratory tract infections
which may become severe in young children

A

Human Bocavirus (HBoV)

67
Q

Human Bocavirus (HBoV) mot

A

respiratory droplets

68
Q

diagnosis` for Human Bocavirus (HBoV)

A

PCR, antigen detection, immunofluorescence, electron microscopy

69
Q

Cell receptor: of parvovirus

70
Q

parvovirus B19

Cell receptor: P antigen found in the surface of

A

red blood cells, erythroid progenitors, vascular endothelium and fetal myocytes

71
Q

parvovirus causes Infections such as

A

Infections causes no symptom or mild illness such as flu symptoms,
rashes and joint pains

72
Q

slapped cheek” rash in children, and joint pains in adults is caused by

A

Parvovirus B19

73
Q

parvovirus on Individual with weakened immune system can cause

A

low blood
count

74
Q

parvovirus on Individual having a pregnancy can cause

A

miscarriage

75
Q

parvovirus b19

  • Virus spreads by
A

respiratory and oral secretion

76
Q

parvovirus b19

Worldwide prevalence typically in __

77
Q

Incubation period of parvovirus b19

A

12-18 days

78
Q

At risk group of parvovirus b19

A

Pregnant women, immunocompromised patients and
those with hemolytic anemia

79
Q

swelling of joint

A

Polyarthropathy Syndrome

80
Q

Polyarthropathy Syndrome is caused by

A

parvovirus

81
Q

Polyarthropathy Syndrome caused by parvovirus usually last____

A

1-3 weeks but can last for months

82
Q

do Polyarthropathy Syndrome goes away without any long term problems?

83
Q

parvovirus infection

due to infection of red blood cell pre-cursors and
immune-mediated destruction

A

aplastic crisis

84
Q

”slapped-cheek disease”
* Common in children aged 4-11 years
* May be associated with lymphadenopathy and joint symptoms

A

erythema infectiosum

85
Q

excessive fluid build up in the fetus caused by parvovirus

A

hydrops fetalis

86
Q

Diagnosis for parvovirus b19

A

Antibody Testing (Parvovirus IgM)-
pcr
pcr and antibody testing using cord blood

87
Q

this diagnosis is for acute infection of parvovirus

A

antibody testing (parvovirus IgM)

88
Q

this diagnosis is for acute infection of parvovirus especially immunocompromised and patients with aplastic crises

89
Q

this diagnosis is for fetal infection caused by parvovirus

A

PCR and antibody testing using cord blood

90
Q

treatment for parvovirus

A

supportive care

91
Q

5th disease of parvovirus b19

A

erythema infectiosum

92
Q

parvovirus b19 is under what genus

A

erythroparvovirus

93
Q

PAPOVA IN PAPOVAVIRIDAE means

A

papilloma
polyoma
vacuolating

94
Q
  • Naked icosahedral capsid containing circular double stranded DN
A

PAPOVAVIRIDAE

95
Q

Papillomaviridae will result to

A

Warts, condylomas, papillomas, cervical cancer

96
Q

Polyomaviridae will result to

A

BK Virus, JC virus, Merkel Cell Polyomavirus,
Trichodysplasia spinulosa Polyomavirus

97
Q

Papillomaviruses size

98
Q

papillomaviruses Can cause infections in

A

humans, dogs, cattle, monkeys and many
other species

99
Q

Viral tropism of HPV

A

cutaneous/mucosal tissue

100
Q

papillomaviruses is * Divided into more than ___serotype

101
Q

in papilloma virumes, Envelope proteins E___ are transforming proteins associated with
initiating cancer

102
Q

HPV high risk genotypes cause ce___ cancer

A

cervical, vulvar, vaginal, squamous cell
oropharynx, anal and penile

103
Q

how many percent of all cervical cancers are caused by Hhuman papilloma virus

104
Q

in the 95% of the cervical cancers caused by HPV, the 70% is caused by

A

hpv 16 and 18

105
Q

MOT of Papillomaviruses

A

Sexual, Vertical, Direct contact with infected material

106
Q

Incubation period pf papillomaviruses

A

genital warts- 3 months after exposure,
cancer - several years from the acquisition of infection

107
Q

Clinical Manifestations of papillomaviruses in skin

A

common warts
flat warts
epidermodysplasia verruciformis

108
Q

common warts (verruca vulgaris ) is caused by what HPV

109
Q

Flat Warts (Verrucae plana) is caused by what HPV

110
Q

Mucus Membrane clinical manifestation of papillomaviruses

A

genital wats
\laryngeal warts

111
Q
  1. Genital Warts is caused by what HPV
112
Q

Laryngeal Warts is caused by what HPV

113
Q

Carcinoma clinical manifestation of papillomaviruses

A

cervical cancer
other cancers such as cancer of squamous cell carcinoma found in penis, vulva, vagina, laryngeal carcinoma

114
Q

Cervical cancer is caused by what HPV

A

16, 18, 31, 33, 35

115
Q

Diagnosis for papillomaviruses

A

Histopathologic or cytologic examination of cutaneous
biopsy or cells, DNA probe assays, NAA

116
Q

treatment for papillomaviruses

A
  • Self-limiting and normally recede in 6-12 months
  • Ablative treatments with podophyllin or liquid nitrogen
  • Vaccines: Cervarix, Gardasil (HPV 6 and 11), and Gardasil-9 (HPV
    31, 33, 45, 52, 58
117
Q

Polyomavirus size

118
Q

characteristic of a Polyomavirus

A

icosahedral, naked, circular double-stranded DNA

119
Q

polyomavirus is Believed to be transmitted through

A

respiratory or oral secretions

120
Q
  • Infections of these viruses usually occur during childhood and
    appears to have little clinical significance.
A

Polyomavirus

121
Q

polyomavirus

  • Latency in __ can result in symptomatic
    reactivation
A

kidney and B lymphocytes

122
Q

MOT of polyomaviruses

A

Respiratory droplets

123
Q

under polyomavirus

Had been isolated in urine from children with cystitis and evidence of
infection has been demonstrated in children with acute respiratory
illness

124
Q

BK virus,

Reactivation in renal transplant patients can result to

A

urethral strictures

125
Q

bk virus, reactivation in bone marrow transplant patients can cause

A

hemorrhagic cystitis

126
Q

Treatment for BK virus

127
Q

Diagnosis for BK virus

A

PCR (blood and urine), Electron Microscopy of urinary sediments

128
Q

under polyomavirus that is * Clinical importance in patients who are immunosuppressed due to
T-cell dysfunction in whom the virus reactivates to cause progressive
multifocal leukoencephalopathy (PML)

129
Q

diagnosis for JC virus

A

PCR (Brain biopsy or CSF), Serological Assays, Histological
examinations

130
Q

MCPv integrates its DNA into the genome of

A

Merkel Cells

131
Q

Diagnosis for merkel cell polyomavirus

A

Tumor biopsy, PCR | Treatment: Surgery, Immunotherapy

132
Q

Growth of abnormal hair-like structures in the skin

A

Trichodysplasia Spinulosa Polyomavirus

133
Q

Clinical presentation: red scaly patches on skin, itching or discomfort,
hair like growths

A

Trichodysplasia Spinulosa Polyomavirus

134
Q

diagnosis of Trichodysplasia Spinulosa Polyomavirus

A

Skin biopsy | Treatment: Cidofovir cream, Corticosteriods,
Laser therapy

135
Q

viruses under polyomaviruses

A

John Cunningham (JC), BK Virus, Merkel Cell
Polyomavirus, Trichodysplasia spinulosa polyomavirus

MYCV (16 decks)

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