VIROLOGY - Filoviridae, FLAVIVIRUSES, HEPEVIRUS, HEPADNAVIRUS Flashcards
flaviviridae’s structure
enveloped positive sense ssRNA
important arthropod-borne viruses in human and veterinary medicine
flavivirus
MOT for flaviviridae
mosquitoes and ticks
geographical distribution of flaviviridae
worldwide expect polar regions
what are the mosquito borne flaviviruses
- Encephalitis viruses
- St. Louis Encephalitis: Americas, Caribbean
- Japanese Encephalitis: N and SE Asia, India
- Murray Valley Encephalitis: Australia
- West Nile: Africa, Asia, Europe
- Ilheus: Central and South America
- Yellow Fever
- Dengue types 1, 2, 3 , 4
what are the tick borne flaviviruses
- Russian Spring-Summer Encephalitis: Russia
-Central European Encephalitis: Western and Central Europe
what does it mean to be an arboviruses
the vectors are arthropods
flavivirus; name is derived from the latin flavus means
yellow
Zira virus infection were discovered in what country
brazil
what is the first disease identified in flaviviridae
yellow fever
the out break in brazil caused by zika virus led to reports of what syndrome, it was been find out as well to cause pregnant women giving birth to babies with birth defects and poor pregnancy outcomes
guillain barre syndrome; zika virus
this disease caused by a flaviviridae became one of the great plagues throughout the history and is known to cause jaundice to patients
yellow fever
reservoir and vector of yellow fever
monkey as reservoir and mosquito is the vector
the first virus clearly associated with transmission by a mosquito
yellow fever - flavivirus
incubation period of yellow fever
3-6 days
mortality rate of yellow fever
5-50%
vector of yellow fever
aedes agypti
the post prevalent arbovirus in the world
dengue virus
vector of dengue virus
aedes aegypti
reservoir of dengue virus
human is the natural reservoir
most important mosquito borne disease in the USA
st. louis encephalitis virus
vector of st. louis encephalitis
culex tarsalis
reservoir of st. louis encephalitis
wild birds
diagnosis for yellow fever
rt pcr, serologic assays, and histology
rx or prevention of yellow fever
no specific antiviral treatment
supportive care
vector control
live attenuated vaccine 17-d vaccine
first isolated from a febrile human in the west nile district of uganda in 1937
west nile virus
are responsible for transmission from birds to humans
bridge mosquitoes
principal mosquito vector pf murray valley encephalitis virus
Culex annulirostris
caused by a group B arbovirus (Flavivirus) and transmitted by Culex mosquitoes
JAPANESE ENCEPHALITIS
rural mosquito that breeds in rice
fields -principal vector of japanese encephalitis
Culex tritaeniorhynchus
Control of Japanese Encephalitis
- Formalin inactivated mouse brain vaccine-Nakayama strain
- Live attenuated vaccine—from JE strain SA 14142,
- Vaccination of pigs
Tick-Borne Flavivirus
Russian Spring-Summer encephalitis (RSSE) complex
Central European Encephalitis
MOT of hepacivirus
parenteral/sexual
diagnosis for hepacivirus
anti-HCV EIA
RT PCR
quantitative bDNA
this hepa virus is Usually undiagnosed as it is asymptomatic
HCV
used to monitor antiviral therapy of HCV
RT PCR and quantitative bDNA
