Microbiology Flashcards

1
Q

Etiologi Toxoplasmosis

A

Toxoplasma gondii

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2
Q

Dampak dari infeksi toxoplasmosis

A

Hidrosefalus, korioretinitis, kalsifikasi serebralis

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3
Q

Siklus hidup T. gondii

A
  1. Tropozoit - merah, sitoplasma biru, dalam jaringan hospes
  2. Pseudokista - infeksi kronis, infektif ke hewan/manusia yang memakan daging infected
  3. Ookista - pada mukosa usus halus kucing, keluar dengan feses
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4
Q

Sifat T. gondii

A
  1. Mati diluar tubuh
  2. Obligat interseluler
  3. Mati akibat pemanasan, kekeringan, pembekuan, pencairan
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5
Q

Sekuele pada bayi

A
  1. Ringan : scar korioretinal

2. Berat : ??

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6
Q

Diagnosis Toxoplasmosis saat kehamilan

A
Antibodi IgG dan IgM
Seropositif : titer IgG 1/20 hingga 1/1000
Reinfeksi : titer IgG dan IgM tinggi
Seronegatif : -
Serokonversi : - jadi +
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7
Q

Diagnosis Toxoplasmosis saat prenatal

A

Waktu : 14-27 minggu
Sampel : Kordosentesis/amniosentesis
Pemeriksaan : PCR, ELISA

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8
Q

Tatalaksana obat pada toxoplasmosis

A

Spiramycin 1-3 g/hari
Pyrimethamine 25 g
Sulfadiazine 3 g
selama 3 minggu

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9
Q

Ciri virus rubella

A
  1. Paramyxovirus, genus Morbilivirus RNA single strand
  2. Inkubasi 7-20 hari
  3. Hanya infeksi ke manusia
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10
Q

Diagnosis rubella

A
  1. Viremia 1 minggu

2. Titer maks antibodi 1-2 minggu setelah ruam

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11
Q

Sindrom Rubella Kongenital

A
  1. Lesi mata (Katarak, glaukoma)
  2. Tuli sensorineural
  3. Microcephaly
  4. PDA
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12
Q

Ciri CMV

A
  1. Herperviridae DNA double strand
  2. Intranuclear inclusion bodies (Owl’s eye sign)
  3. Gejala bisa fatal atau laten (paradoxical)
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13
Q

Tipe infeksi CMV

A

??

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14
Q

Diagnosis prenatal CMV

A

PCR, isolasi virus dari amniosentesis

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15
Q

Gejala CMV

A
  1. Oligohidramnion, Polihidramnion
  2. Asites janin
  3. Mikrosefalus, Hidrosefalus
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16
Q

Tatalaksana infeksi CMV

A

Terminasi kehamilan, terutama jika kehamilan < 20 minggu

17
Q

Tipe virus Herpes

A

HSV 1 - genital

HSV 2 - genital

18
Q

Ciri virus herpes

A

DNA, membentuk intranuclear inclusion body eosinofilik

19
Q

Gejala infeksi herpesvirus

A
  1. Ruam genital dengan nyeri

2. Blister pada kulit bayi

20
Q

Tatalaksana antepartum infeksi herpesvirus

A

C-section jika tampak lesi primer

21
Q

Etiologi Vaginosis Bakterialis

A
  1. Mobiluncus
  2. Bacteroides
  3. Prevotella
  4. Haemophillus
  5. Peptostreptococcus
22
Q

Diagnosis Vaginosis bakterialis

A

Scoring Nugent (identifikasi dengan pewarnaan gram)
0-3 negatif
4-6 intermediate
>7 positif

23
Q

Komplikasi Vaginosis bakterialis

A
  1. Preterm
  2. KPD dan preterm KPD
  3. Korioamniositis
24
Q

Tatalaksana Vaginosis bakterialis

A

Metronidazole 500 mg bid 7 hari
gel 0,75% 5 g intravaginal 1 kali selama 5 hari
Klindamisin krim 5% intrvaginal 4 kali selama 5 hari