MCAT BIO CH. 8 PART 1 Flashcards
What is action potential?
Localized area of depolarization of the plasma membrane that travels along an axon
What is synaptic transmission?
Signal exiting the end of an axon at a synapse, transformed into a chemical signal with the release of neurotransmitter into the synaptic cleft
What is the soma?
Central cell body of the neuron
What does the soma contain?
The nucleus and biosynthetic activity takes place
What is the structure axons and dendrites?
Slender projections from the neuron; only one axon and multiple dendrites
What are bipolar neurons? What about multipolar neurons?
- Neurons with only one axon 2. Multipolar
What are synaptic knobs?
A button-like swelling on an axon where it has a synapse (connection) with another neuron
What is the synaptic cleft?
Small gap that chemical messengers travel across after being released from synaptic knob
What is the difference between a neuron and a nerve?
Neuron is a single cell; nerve is a large bundle of many different axons from different neurons
What are the two primary membrane proteins are required to establish the resting membrane potential?
- Na+/K+ ATPase
2. Leak K channels
How does the Na+/K+ ATPase work in regards to its ion pumping?
Pumps three Na out, two K in with hydrolysis of 1 ATP molecule
What type of transport s Na+/K+ ATPase?
Primary active transport
Are there only K+ leak channels?
No; very few sodium leak channels
Because the cells are negative on the inside and positive on the outside, they are described as _____?
Polarized
Action potential, based on the cell being always polarized, is a….?
Disturbance to the membrane potential, a wave of depolarization of the plasma membrane traveling along an axon
After depolarization, what returns the membrane potential normal?
Repolarization
Why is action potential considered electrochemical?
Because its no just movement of electrical impulse (electrons) but also ions
What are key proteins in the propagation of action potentials?
Voltage-gated sodium channels
What happens in response to a change in the membrane potential?
Ion channels open to allow sodium to flow down their gradient into the cell and depolarization
When are the voltage-gated sodium channels opened based on depolarization?
At threshold potential, approx -50 mV
When do the ion sodium channels become inactive? (To what voltage?) based on depolarization?
-35 mV
How does the neighboring neurons also go through depolarization?
Some sodium ions flow down the interior of the axon and depolarize the next section of the membrane
What happens in the beginning of repolarization?
- Na channel inactive
2. K+ channels open but more slowly and for longer
Does the K+ channels cause the mV to return to - 70mV?
No, it overshoots and reaches - 90 mV before the channels close
What is the axons wrapped in?
Insulating sheath called myelin
What are myelin sheaths created by?
Schwann cells
What is Schwann cell?
Type of glial cell; wrap layers of specialized membrane around axons
Where are Schwann cells found? What about the central nervous system?
Peripheral nervous system; myelination accomplished by oligodendrocytes
How does myelin affect the ions in the axons?
No ions can enter or exit the neuron, allowing it to travel and depolarize
What are gaps known in the myelin sheath termed?
Nodes of Ranvier
If there are no membrane depo. and no voltage-gated Na+ channels in regions wrapped in myelin, then where are they located?
Nodes of Ranvier
What is saltatory conduction?
Myelin sheath spending movement of action potential by forcing it to jump from node to node
What glial cells?
Specialized, non-neuronal cells that typically provide structural and metabolic support to neurons
Glial cells generate action potentials T/F
False: they only maintain a resting membrane potential
What are the five types of glial cells you should maybe remember?
- Schwann cells
- Oligodendrocytes
- Astrocytes
- Microglia
- Ependymal cells
Where are astrocytes located and what is their purpose?
CNS; Guide neuronal development and regulate synaptic communication (with neurotransmitters)
Where are microglia located and what is their purpose?
CNS; remove dead cells and debris
Where are ependymal cells located and what is their purpose?
CNS; produce and circulate cerebrospinal fluid
What is equilibrium potential?
No net movement of ions across the membrane
How are equilibrium potential measured (based on what it moves (hint)) ?
Equilibrium potential is specific for particular ion
How do the equilibrium potential of Na and K differ?
Na is + 50 mV while K+ is - 90 mV
What is the name of the equation that can predict the equilibrium potential for a specific ion?
Nersnt equation
What does Eion represent in the equilibrium potential equation?
The equilibrium potential for the ion
What does R represent in the equilibrium potential equation?
Is the universal gas constant
What does T represent in the equilibrium potential equation?
Temperature in Kelvin
What does z represent in the equilibrium potential equation?
valence of the ion
What does F represent in the equilibrium potential equation?
Faraday’s constant
What does [X] represent in the equilibrium potential equation?
concentration of the ion on each side of the plasma membrane
What does the valence of the electron help determine based on the Nersnt equation? What about the concentrations of the ion?
Chemical gradient; electrical gradient
What is the Nersnt equation?
Eion = RT/zF In ( [X]outside /[X]inside)
Since the resting membrane potential is close to the equilibrium potential of K+ (-90 mV), what does that indicate?
There are a large number of K+ leak channels in the membrane
If the cell is almost completely permeable to potassium, which is there a slightly positive mV compared to the equilibrium potential of K+ ?
Because there are a few Na+ leak channels allowing Na+ in
What is the refractory period?
Neuron unresponsive to membrane depolarization and unable to transmit another action potential for a shot period of time
What are the two phases of the refractory period?
- Absolute refractory period
2. Relative refractory period
What is the absolute refractory period?
Neuron will not fire another action potential no matter how strong a membrane depo. is induced
Why can’t the neuron not fire another action potential during absolute refractory period?
Sodium channels have been INACTIVATED (not closed)
What is the relative refractory period?
Neuron can be induced but depo. required is greater than normal because the membrane is hyperpolarized
When do electrical synapses occur?
When the cytoplasm of two cells are joined by gap junctions
When do chemical synapses occur?
End of axons meet their target cells; action potential converted into chemical signal
What happens when the action potential goes through the axon, where does it end up? (based on synaptic transmission)
Synaptic knob
What does the depolarization in the synaptic knob from the action potential causes? (based on synaptic transmission)
Depolarization of the presynaptic membrane opens voltage-gated calcium channels
What does the opening of voltage-gated calcium channels cause? (based on synaptic transmission)
Calcium influx into the presynaptic cell; exocytosis of neurotransmitter stored in secretory vesicles
What happens after the exocytosis of the neurotransmitters that were stored in secretory vesicles? (based on synaptic transmission)
Diffuse across the synaptic cleft
What is the synaptic cleft?
Small space between cells
After the diffusion of neurotransmitter across the s. cleft, what does it do? (based on synaptic transmission)
Binds to receptor proteins in the postsynaptic membrane
What are included in the receptors proteins in the postsynaptic membrane? (based on synaptic transmission)
Ligand-gated ion channels
What does the opening of the ligand-gated ion channels cause? (based on synaptic transmission)
Changes the membrane polarization
What happens to the neurotransmitter that had bonded to the receptor protein? (based on synaptic transmission)
Degraded or removed; terminates signal
What is an example of a chemical synapse commonly used?
Neuromuscular junction between neurons and skeletal muscle
What neurotransmitter is released from the neuromuscular junction?
Acetylcholine (AChE)
What happens in the neuromuscular junction when an action potential reaches such a synapse, based on neuromuscular junction?
Acetylcholine is released into the synaptic cleft
Where does the acetylcholine go when it is released into the synaptic cleft, based on neuromuscular junction?
Binds to the acetylcholine receptor on the surface of the postsynaptic cell membrane
What happens when the acetylcholine receptor is binded to by ACh, based on neuromuscular junction?
The receptor opens its associated sodium channel, allowing sodium to flow down a gradient into the cell
Allowing sodium to flow down a gradient into the postsynaptic cell, does what (based on neuromuscular junction)?
Depolarizes the postsynaptic cell membrane
What happens to the acetylcholine that had bonded to the receptor (based on neuromuscular junction)?
Degraded by the enzyme acetylcholinesterase (AChE)
What is an excitatory neurotransmitter?
Depolarizes the postsynaptic membrane
What is an inhibitory neurotransmitter?
Induce hyper polarization of the postsynaptic membrane
It is not the neurotransmitter that determines the effect on the postsynaptic cell, it is the ________?
Receptor
What is summation?
The decision of a postsynaptic neuron to whether fire an action potential is determined by both excitatory and inhibitory effects of the synapses
What is temporal summation?
Pre-synaptic neuron fires action potentials so rapidly that the EPSPs and IPSPs pile up on top of another
What does EPSPs stand for?
Excitatory postsynaptic potentials
Whatdoes IPSPs stand for?
Inhibitory postsynaptic potentials
What is spatial summation?
The EPSPs and IPSPs from all the synapses on the postsynaptic membrane are summed at a given moment in time
What is the sensory function of a nerve? What is it carried by?
Receiving information; PNS
What Is the integrative function of a nerve? What is it carried by?
Processing the information; CNS
What is the motor function of a nerve? What is it carried by?
Acting on it; PNS
What are two types of effectors?
Muscles and glands
What do motor neurons do?
Carry information from the nervous system toward organs which can act upon that information
What are efferent neurons? Where do they go?
Carry information away from the central nervous system and intervene effectors; carry to effectors
What are sensory neurons?
Carry information towards the central nervous systems
What are afferent neurons?
Sensory neurons that carry information towards the central nervous systems
How do reflexes occur?
Sensory neuron transmits an action potential to synapse with a motor neuron in the spinal cord, causing an action to occur
What is an example of a reflex?
Muscle stretch reflex
What happens during the muscle stretch reflex?
Sensory neuron detects stretching of a muscle, using sensory neuron to contract i
What is a monosynaptic reflex arc?
A reflex involving only two neurons and one synapse
What is an inhibitory interneuron?
A short neuron that forms an inhibitory synapse with a motor neuron
The interneuron is the simple example of the ____ role of the nervous system?
Integrative
What is reciprocal inhibition?
Concurrent relaxation and contraction, basically one and the other
If a reflex occurs without the involvement of the brain, how are we aware of the action?
- Sensory neuron also branches to form a synapse with a neuron leaning to the brain
- Other sensory information is received after the action is taken
What is included in the CNS?
Brain and spinal cord
What is included in the PNS?
All nerves and sensory structures outside of the brain and spinal cord
What are the two categories of the PNS?
- Somatic
2. Autonomic
What is the somatic division of the PNS?
Conscious sensation and deliberate, voluntary movement skeletal muscle is the somatic division
What is the autonomic division of the PNS?
Concerned with digestion, metabolism, circulation, perspiration and other involuntary processes
Where are the two categories of the autonomic division?
- Sympathetic
2. Parasympathetic
What is the sympathetic system?
Fight or flight
What is the parasympathetic system?
Rest and digest