MCAT BIO CH. 11 PART 1 Flashcards
What are the three types of muscle?
- Skeletal
- Cardiac
- Smooth
What are tendons?
Connect muscles, strong connective tissue formed of collagen
What are the four ways skeletal muscles can move?
- Flexing
- Extending
- Abducting
- Adducting
What skeletal muscle movement is flexing?
Muscles can move a joint by flexing
What skeletal muscle movement is extending?
Increasing the angle of the joint
What skeletal muscle movement is abducting?
Moving away from the body’s midline
What skeletal muscle movement is adducting?
Moving towards the body’s midline
What is the only way for bones and joints to move?
By contracting skeletal muscles
What does it mean when a skeletal muscle has an origin?
Point on this bone where the muscle attaches
What does it mean when a skeletal muscle has a muscle insertion?
Point where the muscle attaches on the bone more distant from the center of the body
What are muscles that are antagonistic?
Muscles that are responsible for movement in opposite direction
What are muscles that are synergistic?
Muscles that move a joint in the same direction
When antagonistic muscles receive stimulation by neurons, how do they differ between contraction and relaxation?
Difference in timing of the signal (frequency) and the amount of neurotransmitter released
What are fascicles based on structure of skeletal muscle?
Connective tissue that holds the contractile tissue together in bundles to allow flexibility within the muscle
What are muscle fibers?
Myofibers; single skeletal muscle cell
Where are myofibers found?
Located within each fascicles bundle
What is an important factor of the nucleus of skeletal muscle cells?
They are multinucleate syncytia
How is the multinucleate syncytia formed in skeletal muscle cells?
By the fusion of individual cells during development
What is sarcolemma?
The myofiber cell membrane
What is the sarcolemma made out of?
Of plasma membrane and an additional layer of polysaccharide and collagen
Why is it important for the myofiber to have sarcolemma?
Helps the cell to fuse with tendon fibers
What are myofibrils?
Smaller myofiber units that generate contractile force of skeletal muscle
What are the proteins in the myofibril that generate contraction?
Actin and myosin
What is the difference between actin and myosin when they polymerize?
Actin polymerizes to form thin filaments, myosin forms thick filaments
What is the reason for the striated appearance of the skeletal muscle?
Due to the overlapping arrangement of bands of thick and thin filaments in sarcomeres
What are the sarcomeres bound by?
Z lines
How are the sarcomeres aligned and where are they located?
End to end, in myofibril
Thick filaments are also attached to the Z lines. T/F
False: they are not
Thin filaments attach to each Z line and overlap with ______ in the middle of each ______?
Thick filaments; sarcomere
What are I bands based on myofibril?
Regions of he sarcomere composed only of thin filaments
What are A band based on myofibril?
The full length of the thick filament represents the A band within each sarcomere
What is the H zone based on myofibril?
Region composed of only thick filaments
Where is contraction generated based on myofibril structure?
Overlapping regions of thick and thin filaments
Based on thick and thin filaments, when does contraction occur based on their structure?
When the thin and thick filaments slide across each other, drawing the Z lines of each sarcomere closer together
During muscle contraction, do thick and thin filaments shorten? What shortens?
No they slide across each other; the sarcomere sheens without them changing their lengths
Filament sliding requires….?
ATP hydrolysis
Which protein uses ATP to create movement?
Myosin - sometimes also named myosin ATPase
Each myosin monomer contains a ___ and a ____?
Head and tail
The head of the myosin monomer attaches to what?
The myosin binding site; a specific site on an actin molecule
When myosin and actin are connected, they’re said to be connected by….
A crossbridge
Contraction occurs when what decreased, based on myosin and actin?
When the angle between the head and the tail decreases
What is the first step of filament sliding in skeletal muscle?
Cross bridge formation; myosin has ADP and Pi bond
What is cross bridge formation?
Binding of the myosin head to a myosin binding site on actin
What is the second step of filament sliding in skeletal muscle?
Power stroke from myosin
What is the power stroke from myosin and when does it happen during filament sliding?
Myosin head moves to a low energy confirmation and pulls actin chain towards center of sarcomere; ADP is released and during 2nd step
What happens during step two then myosin head moves to a low energy confirmation?
They pull actin chain towards center of sarcomere
In which step of filament sliding does a new ATP molecule binds?
Step 3
What is the third step of filament sliding in skeletal muscle?
ATP binding necessary to release actin by the myosin head
What is the four step of filament sliding in skeletal muscle?
ATP hydrolysis, myosin head cocked formation
What does is mean when mentioned the myosin heads are cocked?
Set in a high-energy conformation
In the myofiber, contraction only occurs when…?
The cytoplasmic Ca2+ increases
Which molecule contains troponin-tropomyosin complex?
Thin filaments
What does troponin-tropomyosin complex?
Prevents contraction when Ca2+ is not present
What is tropomyosin?
A long fibrous protein that winds around the actin polymer, blocking all the myosin-binding sites
What is troponin?
A globular protein bound to the tropomyosin that can bind Ca2+
What happens to troponin when it binds to Ca2+?
It undergoes conformation change that moves tropomyosin out of the way so that myosin heads can attach to actin
What protein is responsible for ATP hydrolysis during muscle contraction?
Myosin protein with the ATPase activity
What is the neuromuscular junction?
The synapse between an axon terminus and a myofiber
The neuromuscular junction is a single point. T/F
False: A long invagination of the cell membrane - axon terminus is elongated to fill the long synaptic cleft
What is the purpose of the neuromuscular junction?
Allow the neuron to depolarize a large region of the postsynaptic membrane at once
What is the motor end plate?
The postsynaptic membrane of the neuromuscular junction
What is the neurotransmitter as the neuromuscular junction point?
ACh acetylcholne
During the impulse transmission at the NMJ, an action potential arrives at the axon terminus and triggers the opening of _______ channels?
voltage-gated Ca 2+ channels
During the impulse transmission at the NMJ, the resulting increase in ________ triggers the _______ of ACh?
Intracellular Ca 2+; release of vesicles of acetylcholine
What does the postsynaptic membrane contain to read ACh?
Contains ACh receptors which are ligand-gated Na+ channels
Based on impulse transmission in NMJ, how does ACh reach their receptors?
By diffusing across the synaptic cleft
What happens when ACh binds to the receptors of the postsynaptic membrane receptors?
A postsynaptic sodium influx, which depolarizes the postsynaptic membrane
What is the end late potential?
The depolarization of the postsynaptic membrane when ACh binds to the receptors of the postsynaptic membrane
What is the miniature EPP?
The smallest measurable AP dcaused by exocytosis of a single ACh vesicle
When does ACh stop stimulating postsynaptic receptors?
Until it is destroyed by acetylcholinesterase
What are T-tubules?
Transverse tubules; deep invaginations of the cell membrane which allow the AP to travel into the thick cell
What is the structure of the sarcoplasmic reticulum?
A huge, specialized smooth endoplasmic reticulum that enfolded each myofibril in the cell
What is the SR specialization?
Specialized to sequester and release Ca 2+
How is the calcium removed from the SR?
Active transporters remove calcium from the sarcoplasm
What is the sarcoplasm?
Myofiber cytoplasm
What happens when the AP travels down the T-tubular network?
It depolarizes the cell and the sarcoplasmic reticulum
The sarcoplasmic reticulum contains what? What does it allow?
Voltage-gated Ca 2+ channels, allows calcium to rush out of the SR into the sarcoplasm upon depolarization
When the cell myofiber repolarizes, what happens to the calcium?
It is actively sequestered by the SR and contracted is ended
The smallest measurable muscle contraction is know as….?
Muscle twitch
What are the two ways the nervous system can increase the force of contraction?
- Motor unit recruitment
2. Frequency summation
What is a motor unit?
A group of myofibers innervated by the branches of a single motor neuron’s axon
What does a muscle twitch result from?
The activation of one motor neuron and a larger twitch can be obtained by activating more motor neurons
What is a motor unit recruitment?
Activating or recruiting more motor neurons and thus more myofibers
When does each contraction ends?
When the SR returns calcium to low resting levels