MACROSCOPIC AND MICROSCOPIC ANALYSIS OF THE REPRODUCTIVE SYSTEM Flashcards
MALE REPRODUCTIVE SYSTEM
- Testis
- Genital Ducts
- Accessory Glands
- Penis
Overall Functions of Male Reproductive System:
- Production of Sperm
- Secretion of Hormones
- Production of substances required for sperm activity
Semen
spermatozoa + secretions
TESTES
Regions:
- Tunica Albuginea (dense connective tissue)
- Mediastinum Testis ( fibrous regions)
- Testicular Lobules
-each lobule contains seminiferous tubules
containing interstitial cells (of Leydig).
Testicular Lobules
Leydig Cells/ Interstitial Cells
- Round, Polygonal
- Central Nuclei
- Eosinophilic Cytoplasm
- 250 – 1000 tubules per Testicular Lobule
Seminiferous tubules
Seminiferous tubules
Contains:
> Spermatogenic epithelium
Basement Membrane
Myoid Cells ( for contraction)
Sertoli cells
> Physically and metabolically support developing sperm cell precursors
Steroli Cells
> Produce androgen-binding protein, which concentrates testosterone
Secrete fluid that carries sperm along the tubules
Steroli Cells
shed debris from differentiating
spermatids,
Phagocytoses
Spermatids undergo spermiogenesis
-Condensing of nucleus
- Formation of flagellum w/ mitochondrial middle piece
-Formation of Acrosomal Cap
EXCRETORY GENITAL DUCTS
- Epididymis
- Ductus Deferens/ Vas Deferens
- Urethra
EXCRETORY GENITAL DUCTS
Collective Function:
transport sperm from scrotum to penis during ejaculation.
4-5m in length
* WHERE MATURATION OCCURS
* Lined with pseudostratified columnar epithelium
Epididymis
Epididymis Regions:
a. Head
b. Body
c. Tail
Passage of Sperm through epididymis takes
2-4 weeks.
- Also has pseudostratified column.
Ductus/ Vas Deferens
- Has three layers of smooth muscle
> Peristaltic movement
Epith
- Produce Secretions mixed with sperm to produce
semen
ACCESSORY GLANDS
ACCESSORY GLANDS
- Seminal Gland/ Vesicle
- Prostate Gland
- Bulbourethral Gland
- Lined with both simple and pesudostratified
columnar epithelium (containing secretory cells) - Exocrine Glands
- Secretion makes up 70% of ejaculate
Seminal Vesicles
Seminal Vesicles
-Secretion makes up 70% of ejaculate, containing:
> Fructose
Prostaglandins
Fibrinogen
- Collection of 30-50 tubuloacinar glands embedded in a dense fibromuscular stroma
Contains three zones (arranged around the urethra)
Prostate Gland
- contains mucosal glands
Transition Zone (5%)
- contains submucosal glands
Central Zone (25%)
- contains main prostate glands
Peripheral Zone (75%)
- AKA Cowper glands
- Empties into proximal part of penile urethra
Bulbourethral Gland
- Contians three cylindrical masses of
erectile tissue, penile urethra and skin
PENIS
Corpora Cavernosa
dorsal
Corpus Spongiosum
ventral
> pseudostratified columnar epithelium
Penile Urethra
Retractable fold in skin with sebaceous
glands
Foreskin (prepuce)
> Blood filling cavernous spaces in tissue
Triggered by external stimuli to CNS
Controlled by autonomic nerves
Penile Erection
> Relaxes muscle of the small helicine arteries and adjacent tissues, allowing vessels of the cavernous tissue to fill with blood
Enlargement of corpora muscles
Parasympathetic Stimulation
Occurs at ejaculation
Sympathetic Stimulation
FEMALE REPRODUCTIVE SYSTEM
- Paired Ovaries
- Paired Oviducts (Uterine Tubes)
- Uterus
- Vagina
- External Genitalia
- Mammary Glands
> Not part of Reproductive System per se, but undergo changes directly connected to the functional state of reproductive organs.
Mammary Glands
- “almond shaped”
- Contains a Cortex and Medulla
Ovaries
Ovaries Contain the following epithelium:
> Cuboidal
Surface/Germinal
Tunica Albuginea
– loose connective tissue
- blood vessels
Medulla
– cellular connective tissue
- contains ovarian follicles
Cortex
- Consists of an oocyte surrounded by layers of
epithelial cells and lamina
Ovarian Follicles
-Formed from developing fetal gonad
-Contains one primary oocyte arrested in meiotic
prophase I
Primordial Follicles
- Develop from primordial follicles
- Enlarging primary oocyte surrounded by larger
epithelial cells now called granulosa cells
Primary Follicles
-Responsible for steroid hormone production
during maturation
Granulosa Cells
-Contains glycoproteins (ZO proteins) to which
the sperm surface must bind to reach the oocyte at
fertilization
Zona Pellucida
Follicular Growth and Development
> Onset of Puberty
Initiated by Follicle Stimulating Hormone
Growth of Oocytes
Proliferation and Changes in Follicular Cells
Formation of Secondary/Antral Follicles
Formation of Graffian Follicles
Oocyte Differentiation
- Growth of Cell and Nuclear Enlargement
- Production of more Mitochondria
- RER becoming more extensive
- Enlargement of Golgi Complex
- Formation of Cortical Granules
What happens at follicular growth?
- Formation of Unilaminar Primary Follicle
- Formation of Multilaminar Primary Follicle
- Formation of Zona Pellucida
- Formation of Follicular Theca
*Involves movement of a very large, dominant graafian follicle to the ovary surface
*Completion of meiosis I,
*Release of a polar body from the oocyte
Forms the Corpus Luteum
Ovulation
estrogen
Granulosa Lutein
progesterone
Theca Lutein
- Where the secondary oocyte enters
- Where oocyte degenerates if not fertilized
UTERINE TUBES OR OVIDUCTS
Regions of Uterine Tubes
- Infundibulum
- Ampulla
- Isthmus
- Intramural part
> with fimbrae
Infundibulum
> longest region
where fertilization normally occurs
Ampulla
> narrower portion near the uterus
Isthmus
> passes through uterine wall
Intramural part
“Pear Shaped” Organ
UTERUS
Uterine Wall
* Three Layers:
- Perimetrium
- Myometrium
- Endometrium
> covered by mesothelium
Perimetrium
> highly vascularized
Myometrium
> simple columnar epithelium
Endometrium
UTERUS Regions:
- Fundus
- Isthmus
- Cervix
entry point of the uterine tubes
Fundus
> cylindrical structure
Has two openings:
Cervix
main uterine lumen
Internal Os
to vagina
External Os
*Narrow, inferior end of uterus.
*Endocervical Mucosa is lined with simple columnar epithelium
* Contains cervical glands
> secretes mucous
CERVIX
s lined with nonkeratinized simple sq. epithelium
Exocervical Mucosa
*Lacks Glands
VAGINA
VAGINA Consists of
> Mucosa
Muscular Layer
Adventitia
Epithelium of vagina is
stratified squamous
which is later metabolized by bacteria into lactic acid,
giving low pH of Vagina
Squamous cells accumulate glycogen
*AKA Vulva:
* All contain stratified sq. epithelium
EXTERNAL GENITALIA
> contains tubuloacinar glands
Vestibule
lacking hair follicles; has oil glands
Labia Minora
similar histologically to skin of
scrotum
Labia Majora
erectile structure similar to penis
Clitoris
*Alveolar secretory units develop after puberty
on a branching duct system with lactiferous sinuses converging at the nipple.
* Highly modified Apocrine Sweat Glands
MAMMARY GLANDS
Milk secretion
lactation
which begins in late pregnancy and continues until weaning, involves both protein exocytosis and apocrine secretion of lipid droplets
Milk secretion (lactation)