MACROSCOPIC AND MICROSCOPIC ANALYSIS OF THE URINARY SYSTEM Flashcards
COMPONENTS OF URINARY SYSTEM
-Kidneys
-Bladder
-Ureters
-Urethra
RENAL FUNCTIONS
- Acid-Base Balance
- Excretion of metabolic wastes
- Excretion of bioactive substances
- Secretion of renin
- Secretion of erythropoietin
- Conversion of Vitamin D
- Gluconeogenesis
- stains darker than medulla
Cortex
contains 8-12 renal pyramids containing a
renal lobe
Medulla (inner)
- apical end contains renal papilla and minor calyx
that eventually become one of three major clayces - are separated by structures called renal columns
Renal Pyramids
- Where renal artery and vein are located
- The ureter exits the kidney from here
Renal Hilum
- Largest
- Divides into 2 segmental arteries at hilum
Renal Artery
- Branch from segmental arteries
- Extend between renal pyramids towards
corticomedullary junction
Interlobar Arteries
- Branches from interlobar arteries
Arcurate Arteries
- Branches from arcurate arteries
- Extend all the way to renal cortex
Interlobular Arteries
- Where blood is filtered in the kidney
- drained by efferent arterioles
glomeruli
- branch into peritubular capillaries
Efferent arterioles
Functional units of the kidney
* 1- 4 million
NEPHRONS
Major Divisions of Nephron
- Renal Corpuscle
- Proximal Tubule
- Loop of Henle
- Distal Tubule
- Connecting Tubule
- links nephron to collecting ducts
Connecting Tubule
- Dilated part enclosing a tuft of capillary loops
- SITE OF BLOOD FILTRATION
RENAL CORPUCSCLE
RENAL CORPUCSCLE Contains the ff
- Glomerulus
- Glomerular Capsule ( Bowman’s Capsule)
- Podocytes
> Simple Squamous Epithelial
- Glomerular Capsule ( Bowman’s Capsule)
> Satellite Epithelial Cells
Compose the apparatus for renal filtration
Podocytes
GLOMERULUS Three Parts:
- Fenestrated Capillary Endothelium
- Fused Basal Laminae
- Slit Pores
> Contains Type IV Collagen
Produced by Podocytes
Fused Basal Laminae
For Reabsorption and Secretion of Substances
NEPHRON TUBULES
- located at renal cortex
Proximal Convoluted Cuboidal Tubule
Proximal Convoluted Cuboidal Tubule
> Simple Cuboidal Cells
Contains Microvilli
Abundant Mitochondria
Basolateral Folds
Proximal Convoluted Cuboidal Tubule
Molecules Reabsorbed:
-Glucose
-Amino Acids
-Electrolytes
-Water
- With Thin Ascending and Thin Descending parts
-contains SQUAMOUS epithelial - Also contains Thick Ascending Limb
> Further thickens to macula densa
Loop of Henle
- Specialized smooth muscle cells
- Have juxtaglomerular cells
> Secrete renin
Macula Densa
Where Electrolyte Levels are adjusted further
Distal Convoluted Tubule
- Join to form the cortical collecting ducts
> simple cuboidal epithelium
Connecting Tubules
> pale staining
few mitochondria
contain cell membranes rich in aquaporins
- for passive water reabsorption
delivers filtrate of plasma into minor calyces
Principal Cells
urine is also called
Filtrate
The calyces, renal pelvis, ureters, and urinary
bladder are lined by
urothelium
- Contain Large Bulbous superficial cells called
umbrella cells that contain uroplakin
> protect cytoplasm
UROTHELIUM
- Where urine temporarily is stored
- Contains folded mucosa which unfold as bladder fills.
- Transitional epithelium gets thinner as bladder fills
URINARY BLADDER
- Drains the bladder
- Lined initially by urothelium
URETHRA
is followed by stratified and pseuostratified
columnar epithelium
Urothelium
Male Urethra has three regions:
> Prostatic Urthera
Membranous Urethra
Penile Urethra
> Last portions of male urethra is
stratified squamous
epithelium