Cells and Tissues Flashcards
- Robert Hooke looks at cork under a microscope
1665
Cell is the basic unit of biological structure and function.
Cell Theory
Mathias Schleiden
1838
Theodore Schwann
1839
Rudolf Virchow
1858
• Entire organism is not merely a group of independent units but rather a living unit subdivided
into cells, which are connected and coordinated into a harmonious whole.
Organismal Theory
Organismal Theory
(1879) Anton de Bary
smallest unit of living structure capable of independent existence,
composed of a membrane-enclosed mass of protoplasm and containing a nucleus.
CELL
are the living structural and functional units enclosed by a membrane.
CELLS
are the living structural and functional units enclosed by a membrane.
CELLS
the study of cellular structure and function
CYTOLOGY
•All organisms are composed of one or more cells
•Chemical reactions of living organisms, including its energy-related
processes and its biosynthetic processes occur within the cell
•Cell contain the hereditary information of the organisms of which they
are part.
Cell Theory (Modern Form)
• First to arise in biological evolution
• Generally solitary with then nuclear material unenclosed in a membrane
Prokaryotic Cells
• Multicellular and provided with a nuclear membrane
• Larger and more complex, with a wider range of diversity and differentiation
Eukaryotic
Cell Functions
• Basic Unit of Life
• Protection and Support
• Movement
• Communication
• Metabolism and energy
release
• Inheritance
Physiologic Properties of Cells
• Excitability
• Conductivity
• Contractility
• Absorption and Secretion
• Excretion
• Respiration
• Growth and Reproduction
• Organization
PRINCIPAL PARTS OF THE CELL
A. Cell Membrane
B. Cytoplasm
C. Nucleus
• Flexible yet sturdy barrier that surrounds and contains the cytoplasm of a cell.
• Fragile, transparent barrier that contains the cell contents and separates them from the surrounding environment
Cell Membrane
the arrangement of molecules within the membrane resembles a sea of lipids containing many types of proteins.
• The lipids act as a barrier to certain substances.
• The proteins act as “gatekeepers” to certain molecules and ions
The fluid mosaic model
Cell Membrane Functions
• Gives shape to the cell
• Separates the cell from its
environment
• Serves as recognition sites
• Serves as selective barrier
Membrane Proteins
A. Integral protein
B. Peripheral protein
C. Glycoprotein
D. Glycocalyx
• extend into or through the lipid bilayer among the fatty acid tails and are firmly embedded in it.
Integral protein
• attached to the polar heads of membrane lipids or to integral proteins at the inner or outer surface of the membrane.
Peripheral protein
• Membrane proteins with a carbohydrate group attached that protrudes into the extracellular fluid
Glycoprotein
• “sugary coating” surrounding the membrane made up of the carbohydrate portions of the glycolipids and glycoproteins
Glycocalyx
The cell is either permeable or impermeable to certain substances.
MEMBRANE PERMEABILITY
means that a structure permits the passage of substances through it.
Permeable
means that a structure does not permit the passage of substances through it.
Impermeable
GRADIENTS ACROSS THE PLASMA MEMBRANE
• Concentration gradient
• Electrical gradient
Electrochemical gradient
is the difference in the concentration of a chemical between one side of the plasma membrane and the other.
Concentration gradient
is the difference in concentration of ions between one side of the plasma membrane and the other.
Electrical gradient
Together, these gradients make up an
Electrochemical gradient
TRANSPORT MECHANISMS ACROSS THE PLASMA MEMBRANE
I. Passive Process
II. Active Process
I. PASSIVE PROCESS
A. Simple diffusion
B. Osmosis
C. Facilitated Diffusion
D. Filtration
Net movement of particles from an area of higher concentration to an area with lower concentration, that is along their concentration gradient
Simple diffusion
Simple diffusion of water through a selectively permeable membrane
Osmosis
Same as simple diffusion but the diffusing substance is attached to a lipid soluble carrier
Facilitated Diffusion
Movement of water and solutes through a semi-permeable membrane from an area with higher hydrostatic pressure to an area with a lower hydrostatic pressure, that is, along a pressure gradient
Filtration
II. ACTIVE PROCESS
A. Active transport
B. Exocytosis
C. Endocytosis
D. Phagocytosis
E. Pinocytosis
F. Receptor Mediated Endocytosis
• Movement of substance through a membrane against a concentration or electrochemical gradient and requires a membrane carrier protein
Active transport
Secretion or ejection of substances enclosed in a membrane vesicle which fuses with the plasma membrane and ruptures
Exocytosis
Engulfed extracellular substance are brought to the cytoplasm in a membrane-limited vesicle
Endocytosis
Cell eating; insoluble substances are engulfed and are enclosed in a vesicle known as “phagosome”
Phagocytosis
Cell eating; insoluble substances are engulfed and are enclosed in a vesicle known as
Phagocytosis
Cell drinking; engulfment of small amount of fluid enclosed in pinocytic vesicles
Pinocytosis
External substances binds to membrane receptors and are engulfed with their receptors
Receptor Mediated Endocytosis
• The protoplasm outside the nucleus which contains the different organelles and
inclusions
• Divided into an outer gel-like ectoplasm and an inner more liquefied endoplasm
• Cytosol: the clear fluid portion in which the particles are dispersed
B. Cytoplasm
FORMED ELEMENTS OF THE CYTOPLASM
I. Organelles
II. Inclusions
III. Cytoskeleton
• Metabolically active internal organs carrying out specific essential functions
Organelles
Metabolically inert accumulations of cell products
Inclusions
• Responsible for the gel-like consistency of the cytoplasm
• Forms the structural support or framework of the cell
Cytoskeleton
I. ORGANELLES
A. Mitochondria
B. Ribosomes
C. Endoplasmic Reticulum
D. Golgi complex
E. Lysosomes
F. Centrosome
G. Cilia and Flagella
II. INCLUSIONS
A. Glycogen
• Storage form of carbohydrates in animal cells
B. Lipid
• Serves as energy source
• For synthesis of membranes
C. Pigments
D. Crystals
• Least common among the inclusions
III. CYTOSKELETON
A. Microfilaments
B. Intermediate filaments
C. Microtubules
• help generate movement and provide mechanical support
• thinnest elements of the cytoskeleton
• Composed of actin & myosin
Microfilaments
thicker than microfilaments but thinner than microtubules
Intermediate filaments
• largest of the cytoskeletal components and are long, unbranched hollow tubes composed mainly of the protein tubulin
Microtubules
• Control center of the cell
• Repository of genes which are the carriers of hereditary traits of an individual
• DNA is the principal nucleic acid of chromatin
Nucleus
• a single molecule of DNA associated with several proteins, contains thousands of hereditary units called genes.
Chromosome
control most aspects of cellular structure and function
Genes
• Shortest period of the cell cycle
• Nuclear division and Cytoplasmic division
CELL DIVISION
-is a group of cells that usually have a common origin in an embryo and
function together to carry out specialized activities.
-may be hard, semisolid, or even liquid in their consistency, a range
exemplified by bone, fat, and blood.
Tissue
is the science that deals with the study of tissues
Histology
is the science that deals with the study of tissues
Histology
is a physician who specializes in laboratory studies of cells and
tissues to help other physicians make accurate diagnoses.
Pathologist
are contact points between the plasma membranes of tissue cells.
CELL JUNCTIONS
are contact points between the plasma membranes of tissue cells.
CELL JUNCTIONS
CELL JUNCTIONS
Examples:
- Tight Junction
- Adherens Junction
- Desmosome
- Hemidesmosome
- Gap/ Communicating Junction
TYPES OF TISSUES
- Epithelial
- Connective
- Muscular
- Nervous
- Also know as Occluding Junctions or Zonula Occludens
-consist of web-like strands of transmembrane proteins that fuse together the outer surface of the adjacent plasma membrane to seal off passageways between adjacent cells
Tight Junctions