Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Microbiology 2 > M6 Staphylococcus > Flashcards

M6 Staphylococcus Flashcards

You may prefer our related Brainscape-certified flashcards:
Biology 101 flashcards
1
Q

what are some major strains of staphylococcus

A

s. aureus

s. epidermidis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what are some common features of staphylococcus

A 
gram +ve 
non motile
irregular shape 
aureole and facultative anaerobe 
catalase +ve 
oxidase -ve 
can be coagulase +ve or -ve
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

how common is s. aureus

A

20% colonisation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

where is s.aureus common

A

anterior nares and perineum

nosocomial and community

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what is MRSA

A

mainly nasocoimal
elderly and immunosuppressed
ICU

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what is the colonisation of s.epidermidis

A

100%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

where is s.epidermidis found

A

skin and mucous mems

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what si a nosocomial infection

A

assc with forgein devices - catheters

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what is the common direct contact transmission of staph

A

hand and skin or mucous

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what is the common indirect transmission of staph

A

instruments
bedding
door handles

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what si the way staph is air bourne

A

shedding of cocci from infected site into atmosphere

dust or squames

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what kind of bac is staph

A

oppputunisit

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what are staph means of entry

A 
hair follicles and sebaceous glands 
damaged or diseased skin 
broken skin 
catheters 
post influenza pneumonia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what is the pathogenicity of s. aureus

A

superififcal lesions - build to abscess
systemic - life threat
toxinoses - toxic shock

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what sit he carriage of s. aureus

A

anterior nares
perineum
hands
oral cav - age and pros

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what is the significance of s. aureus

A

HAI/nasocomial
oral abscesses
head and neck - ottis media

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

what are the virulence factors of staph

A

attachement
evasion of host defences
invasion/ tissue penetration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

what are some virulence factors

A 
capsule 
coagulate 
fibrinogen bind protein
TSST-1 
adhesins
kills leucocytes
shock 
rash 
desquamation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

what are adhesins

A

extracellular matrix molecules are present on epi, endo surfaces as well as a component of blood clots

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

what is imp about fibrinogen binding

A

fibriiognen cleave from fibrin monomers allows to colonise site

21
Q

wha are some s aureus skin infection

A 
folliculitis 
carbuncle - multiolbualr abscess
impetigo 
abscess
scalded skin syndrome
22
Q

what are some subs used for evasion of host defences

A 
protein A 
proteases 
superantigens 
lipases
coagulate
capsule
23
Q

what are toxinoses

A

TSST-1 toxic shock syndrome toxin 1

rapid progression high fever, sore throat, muscle pain

24
Q

what is the bacteria present in food poisoning

A

staphylococcal enterotoxin

25
Q

what is SSS

A

scalded skin syndrome
exfoliatin toxins
neonatal
face, axilla, groin

26
Q

what are superanitgens

A

bind to outside and staalises reaction in 1/10 T cells turning whole immune system on
assc with toxic shock
massive release cytokines

27
Q

what is diagnostic criteria of TSST-1

A

fever 39
diffuse macular rash - erythroderma- water under skin
hypotension
organ systems failing

28
Q

what does protein A do

A

bind to Fc region of IgG antibodies

produced by exponential growth

29
Q

what is protein a

A

coagulase +ve

activation complenent

30
Q

what do pretences do

A

cleave Ab, defnesins, platelet microbicidal proteins

destroy host tissue

31
Q

hat are lipase, phospholipase and esterase

A

combat surfactants produced to disrupt bacterial mem

post exponentially expressed scavenging enzymes

32
Q

what is Panton Valentine Leukocidin

A

PVL bicomponent toxin
sp toxicity for leucocytes
1-2% strains
assc with severe skin infections

33
Q

what are PVL and alpha toxin linked with

A

CA-MRSA

responsible for necrotising pneumonia and contagious severe kin infections

34
Q

what is necrotising pneumonia

A

preceding influenza like syndrome
rapid progression
acute resp distress
refractory hypoxamenia young and fit community acquired

35
Q

what si coagulase

A

plasma

protective allows clot and ashore but also covers assess host proteins such as fibrin

36
Q

wat does coagulase form

A

staphylothrombin promotes conversion of fibrinogen to fibrin and clotting

37
Q

what is coagulase +ve example

A

synonymous with pathogenic staphylococci

38
Q

what is an example of coagulase +ve an -Ve

A

+ve - s.aureus

-ve - s. epidermis

39
Q

what is fnbA

A

fibronectin adhesin

40
Q

what is cna

A

colagen ashesin

41
Q

what is sdrE

A

bone sialo-bindig

42
Q

what is hlg

A

gamma toxin (leukocidin)

43
Q

what is ica

A

polysaccharide intracellular adhesin

44
Q

what si themes common HAI strain

A

t032

45
Q

what is the regulation of pathogenicity factors

A

transition to exponential protein a,fibronectin binding proteins, surface proteins, coagulase

late expo surface proteins tuned off

stationary has secreted proteins turned on

46
Q

what si most common antibiotic treat

A

peniccilin

47
Q

what is issue with penicillin

A

50-80% resistant (beta-lactamase +ve)

48
Q

what is flucloxacillin

A

beta - lactase resistant use if can’t use penicillin

49
Q

if allergy to penicillin what is used

A

erythromycin

Microbiology 2 (23 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions