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Microbiology 2 > M12 Spirochaetes & ANUG > Flashcards

M12 Spirochaetes & ANUG Flashcards

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Biology 101 flashcards
1
Q

what kind of cell wall does spirochetes have

A

gm -Ve cell wall

doesnt stain well

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2
Q

spirochetes are fastidious what does this mean

A

difficult to grow in lab on agar or broth

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3
Q

are spirochetes common in mouth

A

very common
assc with deep perio pockets
increase with periodontitis

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4
Q

what si struct of spirochetes

A

helical bac
central protoplasmic cyinder
3–5 axial filaments in outer cell envelope

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5
Q

what si the genus of spirochetes

A

Treponema

borrelia

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6
Q

what is borrelia burghdorferi

A

20 sub sp 5 cause disease

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7
Q

what is the disease borrelia burghdorferi cause

A

lymes disease

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8
Q

what is lames disease

A

tick bite - zoonotic
slow grow
microaerophilic spirochete

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9
Q

what is the primary infection of lames disease

A

red spot at bite site the enlarges withal area in middle

red ring

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10
Q

what are the symptoms of lymes disease

A 
headache
drowsiness
mild fever
joint/muscle pain 
swollen lymph nodes
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11
Q

when does he symptoms take effect

A

3-30 days post infection

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12
Q

what happens to 15% people after 1-5 weeks after a tick bite

A

neuro borrelia

- neurological implication

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13
Q

what are the symptoms of euro borrelia

A 
back pain 
numb feel at bite
meningits presntation 
chornic 
lyme arthritis
inflam heart
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14
Q

what does treponema palladium cause

A

csyphilus

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15
Q

what are the symptoms implications of csyphilus

A 
painless chancre
rash 
flu like symptoms 
occasional rash 
neuro and CV madness
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16
Q

what are the diffenret progressions of csyphilus and time

A

primary
- 3 days - 3 months

secondary
- 2 weeks - 24 months

latent
- 1-30 years

tertiary
- 1- greater than 30 years

17
Q

what can congenital syphilus cause

A

vertical transmission mother to child

  • saddle nose
  • hutchisons teeth notched incisors
18
Q

what is used to treat syphilus

A

penicillin

  • 2 million unitsintramuscular Pen G
  • 3 injections for latent syphiuls
19
Q

where are oral treponemes

A

loose assc at edge sub gingival plaque

20
Q

what are some oral treponemes

A

treponema vincentii
treponema denticola (red complex)
treponema oralis

21
Q

what is T denticola

A

larger genome the T palladium
most proteolytic member of red complex
attach at to gingival fibroblast
induce cyttoxicty and cell death

22
Q

what are the stress responses of t denticola

A 
superoxide dimutase (SOD) activity 
arginine deaminase
23
Q

what sit he assc of t deneticola with p gingivalis

A

commonly found assc with each other in chronic perio lesions
congregate
grown in mixed biofilms

24
Q

what does the relationship of t denticola and p gingivalis show

A

increasing evidence of synergistic assc between two periopathogens

25
Q

what is AUG

A

acute (necrotising) ulcerative gingivitis

acute painful true infection of gingiva

26
Q

what is AUG assc with

A

immunosuppression

  • poor oral hygiene
  • smoking
  • malnutrition
  • stress
  • systemic illness
27
Q

what causes AUG

A

a fuso-spirochaetal complex fusobac nucletum and treponema vincentii

28
Q

what other microorg is present at AUG

A

prevotella intermedia

large numbers

29
Q

what is the presentation of AUG

A

acute inflam red and shiny
bleeding
ulcers
lesions

30
Q

what is vincents angina normally assc with

A

AUG

31
Q

what is vin cents angina

A 
infection pharynx 
unilateral sore throat 
increased intensity over several days 
referred earache 
bad taste in mouth 
halitosis 
deep ulcer in one tonsil
32
Q

what does treponema vincentii do

A

spirochetes mix reuird
cell assc proteolytic enzymes
- prod trypsin like proteases
fusobacterium required for essential GF;s

33
Q

what is the treatment of AUG

A

intensive local oral hygiene - ultrasonic scaler
oral hygiene advice and mouth rinses - chlorhexidine
short course Ab
- metronizadole
- 200mg fro 5 days

34
Q

what is cancrum oris (NOMA)

A

severe form AUG

- children developing countries

35
Q

what si the typical pt fro cancrum oris

A

malnourished

measles and leukmai history

36
Q

what doe cancrum oris cause

A

gingival infections spread into the cheeks and face

extensive tissue loss and facial disfigurement

Microbiology 2 (23 decks)

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