M12 Spirochaetes & ANUG Flashcards
what kind of cell wall does spirochetes have
gm -Ve cell wall
doesnt stain well
spirochetes are fastidious what does this mean
difficult to grow in lab on agar or broth
are spirochetes common in mouth
very common
assc with deep perio pockets
increase with periodontitis
what si struct of spirochetes
helical bac
central protoplasmic cyinder
3–5 axial filaments in outer cell envelope
what si the genus of spirochetes
Treponema
borrelia
what is borrelia burghdorferi
20 sub sp 5 cause disease
what is the disease borrelia burghdorferi cause
lymes disease
what is lames disease
tick bite - zoonotic
slow grow
microaerophilic spirochete
what is the primary infection of lames disease
red spot at bite site the enlarges withal area in middle
red ring
what are the symptoms of lymes disease
headache drowsiness mild fever joint/muscle pain swollen lymph nodes
when does he symptoms take effect
3-30 days post infection
what happens to 15% people after 1-5 weeks after a tick bite
neuro borrelia
- neurological implication
what are the symptoms of euro borrelia
back pain numb feel at bite meningits presntation chornic lyme arthritis inflam heart
what does treponema palladium cause
csyphilus
what are the symptoms implications of csyphilus
painless chancre rash flu like symptoms occasional rash neuro and CV madness
what are the diffenret progressions of csyphilus and time
primary
- 3 days - 3 months
secondary
- 2 weeks - 24 months
latent
- 1-30 years
tertiary
- 1- greater than 30 years
what can congenital syphilus cause
vertical transmission mother to child
- saddle nose
- hutchisons teeth notched incisors
what is used to treat syphilus
penicillin
- 2 million unitsintramuscular Pen G
- 3 injections for latent syphiuls
where are oral treponemes
loose assc at edge sub gingival plaque
what are some oral treponemes
treponema vincentii
treponema denticola (red complex)
treponema oralis
what is T denticola
larger genome the T palladium
most proteolytic member of red complex
attach at to gingival fibroblast
induce cyttoxicty and cell death
what are the stress responses of t denticola
superoxide dimutase (SOD) activity arginine deaminase
what sit he assc of t deneticola with p gingivalis
commonly found assc with each other in chronic perio lesions
congregate
grown in mixed biofilms
what does the relationship of t denticola and p gingivalis show
increasing evidence of synergistic assc between two periopathogens
what is AUG
acute (necrotising) ulcerative gingivitis
acute painful true infection of gingiva
what is AUG assc with
immunosuppression
- poor oral hygiene
- smoking
- malnutrition
- stress
- systemic illness
what causes AUG
a fuso-spirochaetal complex fusobac nucletum and treponema vincentii
what other microorg is present at AUG
prevotella intermedia
large numbers
what is the presentation of AUG
acute inflam red and shiny
bleeding
ulcers
lesions
what is vincents angina normally assc with
AUG
what is vin cents angina
infection pharynx unilateral sore throat increased intensity over several days referred earache bad taste in mouth halitosis deep ulcer in one tonsil
what does treponema vincentii do
spirochetes mix reuird
cell assc proteolytic enzymes
- prod trypsin like proteases
fusobacterium required for essential GF;s
what is the treatment of AUG
intensive local oral hygiene - ultrasonic scaler
oral hygiene advice and mouth rinses - chlorhexidine
short course Ab
- metronizadole
- 200mg fro 5 days
what is cancrum oris (NOMA)
severe form AUG
- children developing countries
what si the typical pt fro cancrum oris
malnourished
measles and leukmai history
what doe cancrum oris cause
gingival infections spread into the cheeks and face
extensive tissue loss and facial disfigurement
