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Microbiology 2 > M20 > Flashcards

M20 Flashcards

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Biology 101 flashcards
1
Q

what is sterilisation

A

process by which all living cells viable spores and viruses are detpryed or moved

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2
Q

what isdisinfection

A

killing, inhibition or removal of microorganisms that cause disease

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3
Q

what is sanitisation

A

reduction of microbial population to levels that a re safe for public health

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4
Q

what are some examples of prion based diseases

A 
scrapie = BSE 
creutzfeldt Jacob Disease 
GSS 
fatal familial insomnia 
Kuru
new variant CJD
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5
Q

what are the types of CJD

A

sporadic
inherited
transmitted

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6
Q

what is themes common CJD

A

sporadic

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7
Q

what is the pt for sCJD

A

elderly
dementia
unknown cause

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8
Q

where is highest levels of prion

A

CNS
retina
sensory ganglia
not blood

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9
Q

what is vCJD

A

fatal human neurodegenerative condition

transmissible spongiform encephalopathy

spread to humans via unclean inst

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10
Q

what can be found at position 129 on PRNP codon

A

methionine and valine

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11
Q

what ar ht genotypes of prion P

A

homozygous MM
homozygous VV
heterozygous MV

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12
Q

what re the symptoms of vCJD

A 
av age 28
dementia 
sensory unsteady 
involve moves
immobile 
mute death
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13
Q

what are the effects of vCJD

A

brain vacuolation
neural apoptosis
accumulate misfiled protease resistant prion protein

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14
Q

hat causes vCJD

A

scrapie
BSE
protein only hypothesis lead directly to prion

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15
Q

what is a prion

A

proteinaceous infectious particle

replicate itself in body

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16
Q

what ar the types of prion

A

PrpC conv to PrpSC (accumulates as plaque)

new cone PrpSC makes more PrpC

17
Q

explain few features of PrpC

A

made normally by body
prod in neurons
stability of myelin sheath and memory
identical to PrpSC

18
Q

what si the amount of PrpSC proportional o

A

infectivity

19
Q

what si the life cycle of a prion

A 
uptake via peters patches 
circa blood
accumulates lymphoid 
enters nerves orcorss BBB
accumulates in bain
20
Q

how is vCJD peripherally dist

A 
lymphoid tissue (tonsil, lymph node, spleen)
neural tissue (trigem gang) 
blood for transfusion
21
Q

what are some sites for decontamination

A

cleaning
autoclaving
files and reamers

Microbiology 2 (23 decks)

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