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Microbiology 2 > M11 Gram Negative Bacteria 2 > Flashcards

M11 Gram Negative Bacteria 2 Flashcards

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1
Q

what are some gram negative anaerobic bacilli that are motile

A

selenomonaos
centipeda
helicobacter

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2
Q

what are some gram negative anaerobic bacilli that are non motile

A 
bactericides 
prophorymonans
prevotella
tannerlla
fusobac
leptotrichia
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3
Q

what is tannerella forsythia

A

saccharolytic

non pigmented bacteria

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4
Q

what does tannerlla forsythia do to blood agar

A

pits the surface

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5
Q

what is tannerlla forsythia associated with

A

periodontitis

but not when in isolation

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6
Q

what are some virulence factors of tannerlla forsythia

A 
fibronectin 
apoptosis inducing factor 
protease
hemagglutinin 
mirolysin
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7
Q

what is fibronectin do

A 
BspA
adhesion
invasion 
induces release bone reads pro inflam cytokines 
induces chemokine
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8
Q

what do chemokine do

A

recruit neutrophils
inflammation
tissue destruction

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9
Q

how is the pathogenicity of tannerella forsythia limited

A

polymicrobial
wound chamber does not cause disease
gnotobiotic rats dont colonise efficiently

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10
Q

what are the interactions of tannerlaa forsythia

A

P gingival - enhances attachment to epi cells

forms mixed films with fusobac

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11
Q

what is fusobacterium

A

gram -ve spindle shaped FUSIFORM bac

pathogenic

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12
Q

what are some sub species of fusobacterium nucleate

A

nucleatum
polymorphism
vincentii

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13
Q

what can fusobac bind

A

gram -ve and +ve

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14
Q

what is fusobac mostly involved in

A

saccharolytic

binding organism

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15
Q

where does fusobac colonise

A

gingival sulus

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16
Q

what is the fusobacterium linked to

A

endotoxin linked to periodontitis

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17
Q

what virulence factor of fusobac is involved in extra oral infections

A

FadA
binds to epi cells
enter fibroblasts

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18
Q

what is fusobac nucleatum involved in

A

acute ulcerative gingivitis AUG

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19
Q

what is usually assc with fusobac nucleatum

A

treponema vincentii
spirochaete
= fusospirochateal infection

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20
Q

whatcondiion is assc with fusobac nucleatum

A 
vincents angina
cancrum oris ( AUG tissue destroy and immunosuppression)
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21
Q

when is AUG most common

A

young adults
smokers
ulcers on marginal margins

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22
Q

what can happen from AUG

A

gingival sore and bleed
foul breath
no fever
no swollen lymph nodes

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23
Q

what does fusobac do in terms of AUG

A

induce P kinases assc with cell prolif and migration
stim coagulase 3 expression
immune suppression by apoptosis

24
Q

what does F nucelatum mediate

A

co invasion of s cristasus

25
Q

what is F nucelatum mechanism proposed for

A

colon cancer

26
Q

what is leptotrichia

A

gram -ve anaerobic bacilli
saccharolytic
in pairs
lactic acid

27
Q

what is the main species of leptorichia

A

buccalis

28
Q

what are the features of L buccalis

A

dental plaque
isolated from plaque over caries
galacto syl binding lectins
extra oral infections

29
Q

what are gram -ve facultative anaerobes

A

prefer oxygen

capnophilic (5-10% co2)

30
Q

what are some facultative anaerobes

A

haemophilia
aggregatibacter
eikenella
capnocytophaga

31
Q

what is haempphilus and where is usually found

A

gram -ve
small bacilli
mouth and plaque

32
Q

when are haemophilus present

A

first few days after birth

33
Q

what is the most common haemophilia and where is it found

A

H segnis

supra gingival plaque

34
Q

is haemohilus pathogenic

A

not particularly

35
Q

what are he main aggregatibacter

A

atinomycetecomitans

36
Q

what is aggregatibacter

A 
oral sp in gingival sulcus
gm -ve 
capnophilic 
cocci-bacillus 
periodontopathogen
37
Q

what are some virulence factors for aggreatibacter

A

leukotriene
collegenase
IgG proteases
surface proteins

38
Q

what does leukotoxin do

A

take out leucocytes

39
Q

what is juvenile periodontitis

A

puberty
girls
localised - First molars and incisors
generalised is aggressive

40
Q

what is high in microflora in local JP and what is there

A

actinomycetmcomitans

LPS - pro inflam endotoxin and promote bone loss

41
Q

what does A actinomycetecomitans do

A

rapid destruction periodontitis
JP
papillon leferve syndrome

42
Q

what is pavilion lefevre syndrome

A

skin condone
teeth loss
thick cracked skin

43
Q

what is prescribed for JP

A

tetracycline and beta lactamase

44
Q

what is eikenella

A

gm -ve asaccharolytic small bacillus pits agar

45
Q

what is a sp of eikenella and where found

A

E corrodens

sub gingival plaque

46
Q

what can eikenella do

A

periodontitis
alveolar bone loss
inc gingiviis
clench fist injuries

47
Q

what is capnocytophaga

A

gm -ve fusiform Co2 dept

motile

48
Q

what are some subspecies of capnocytophaga

A

ochraceae
sputigena
gingivalis

49
Q

what does capnocytophaga

A

periodontitis

JP

50
Q

what is an example of curved gm -ve bacilli and where found

A

campylobacter rectus

plaque and per pocket

51
Q

how does periodontitis come about

A

progression from health to gingivitis to periodnotitits

52
Q

what is seen in health

A 
facultative 
- (+) rods and cocci 
anaerobic 
-(-) rods
-(+) rods, cocci
53
Q

what is seen in gingivitis

A 
facultative 
- (+) cocci 
- (+) rods 
- (-) rods 
anaerobic 
- (-) rods 
- (-) cocci
- (+) rods
54
Q

what is seen in periodontitis

A 
facultative 
- (+) rods
- (+) cocci 
anaerobic 
- (-) Rods 
- (+) rods
55
Q

what is the red complex

A

tannerella forsythia
porphyromonas
gingivalis
treponema denticola

56
Q

what is the orange complex

A

prevotella intermedia
prevotella nigrescens
fusobacterium nucleatum

Microbiology 2 (23 decks)

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