M11 Gram Negative Bacteria 2 Flashcards
what are some gram negative anaerobic bacilli that are motile
selenomonaos
centipeda
helicobacter
what are some gram negative anaerobic bacilli that are non motile
bactericides prophorymonans prevotella tannerlla fusobac leptotrichia
what is tannerella forsythia
saccharolytic
non pigmented bacteria
what does tannerlla forsythia do to blood agar
pits the surface
what is tannerlla forsythia associated with
periodontitis
but not when in isolation
what are some virulence factors of tannerlla forsythia
fibronectin apoptosis inducing factor protease hemagglutinin mirolysin
what is fibronectin do
BspA adhesion invasion induces release bone reads pro inflam cytokines induces chemokine
what do chemokine do
recruit neutrophils
inflammation
tissue destruction
how is the pathogenicity of tannerella forsythia limited
polymicrobial
wound chamber does not cause disease
gnotobiotic rats dont colonise efficiently
what are the interactions of tannerlaa forsythia
P gingival - enhances attachment to epi cells
forms mixed films with fusobac
what is fusobacterium
gram -ve spindle shaped FUSIFORM bac
pathogenic
what are some sub species of fusobacterium nucleate
nucleatum
polymorphism
vincentii
what can fusobac bind
gram -ve and +ve
what is fusobac mostly involved in
saccharolytic
binding organism
where does fusobac colonise
gingival sulus
what is the fusobacterium linked to
endotoxin linked to periodontitis
what virulence factor of fusobac is involved in extra oral infections
FadA
binds to epi cells
enter fibroblasts
what is fusobac nucleatum involved in
acute ulcerative gingivitis AUG
what is usually assc with fusobac nucleatum
treponema vincentii
spirochaete
= fusospirochateal infection
whatcondiion is assc with fusobac nucleatum
vincents angina cancrum oris ( AUG tissue destroy and immunosuppression)
when is AUG most common
young adults
smokers
ulcers on marginal margins
what can happen from AUG
gingival sore and bleed
foul breath
no fever
no swollen lymph nodes
what does fusobac do in terms of AUG
induce P kinases assc with cell prolif and migration
stim coagulase 3 expression
immune suppression by apoptosis
what does F nucelatum mediate
co invasion of s cristasus
what is F nucelatum mechanism proposed for
colon cancer
what is leptotrichia
gram -ve anaerobic bacilli
saccharolytic
in pairs
lactic acid
what is the main species of leptorichia
buccalis
what are the features of L buccalis
dental plaque
isolated from plaque over caries
galacto syl binding lectins
extra oral infections
what are gram -ve facultative anaerobes
prefer oxygen
capnophilic (5-10% co2)
what are some facultative anaerobes
haemophilia
aggregatibacter
eikenella
capnocytophaga
what is haempphilus and where is usually found
gram -ve
small bacilli
mouth and plaque
when are haemophilus present
first few days after birth
what is the most common haemophilia and where is it found
H segnis
supra gingival plaque
is haemohilus pathogenic
not particularly
what are he main aggregatibacter
atinomycetecomitans
what is aggregatibacter
oral sp in gingival sulcus gm -ve capnophilic cocci-bacillus periodontopathogen
what are some virulence factors for aggreatibacter
leukotriene
collegenase
IgG proteases
surface proteins
what does leukotoxin do
take out leucocytes
what is juvenile periodontitis
puberty
girls
localised - First molars and incisors
generalised is aggressive
what is high in microflora in local JP and what is there
actinomycetmcomitans
LPS - pro inflam endotoxin and promote bone loss
what does A actinomycetecomitans do
rapid destruction periodontitis
JP
papillon leferve syndrome
what is pavilion lefevre syndrome
skin condone
teeth loss
thick cracked skin
what is prescribed for JP
tetracycline and beta lactamase
what is eikenella
gm -ve asaccharolytic small bacillus pits agar
what is a sp of eikenella and where found
E corrodens
sub gingival plaque
what can eikenella do
periodontitis
alveolar bone loss
inc gingiviis
clench fist injuries
what is capnocytophaga
gm -ve fusiform Co2 dept
motile
what are some subspecies of capnocytophaga
ochraceae
sputigena
gingivalis
what does capnocytophaga
periodontitis
JP
what is an example of curved gm -ve bacilli and where found
campylobacter rectus
plaque and per pocket
how does periodontitis come about
progression from health to gingivitis to periodnotitits
what is seen in health
facultative - (+) rods and cocci anaerobic -(-) rods -(+) rods, cocci
what is seen in gingivitis
facultative - (+) cocci - (+) rods - (-) rods anaerobic - (-) rods - (-) cocci - (+) rods
what is seen in periodontitis
facultative - (+) rods - (+) cocci anaerobic - (-) Rods - (+) rods
what is the red complex
tannerella forsythia
porphyromonas
gingivalis
treponema denticola
what is the orange complex
prevotella intermedia
prevotella nigrescens
fusobacterium nucleatum
