Imp Fungal Infections of the Mouth Flashcards

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1
Q

what are fungi

A

eukaryotes

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2
Q

what is ubiquitous

A

saprophylytic or parasiitc

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3
Q

what is saprophytic

A

break down dead/organic matter

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4
Q

what are some characteristics of fungi

A

repro sexual/asexual
unicellular or filamentous vegetative strutures
budding, binary fission
surrounded by chitin cell wall

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5
Q

what are the four genera fungi

A

candida
cryptococcus
apergillus
pneumocystis

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6
Q

what are some common fungal related infection

A

athletes foot
ringworm
vulvovaginal candidiasis
aspergillosis

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7
Q

what are the two types of fungi

A

yeast mould

dimorphic and polymorphic

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8
Q

what are some yeats

A

single oval cells often reproduce by budding

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9
Q

what are moulds

A

multicellular and comp of tubules or filaments called hyphae

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10
Q

what is a mycelium

A

mass of hyphae

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11
Q

what is ascomycetes

A

candida sp

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12
Q

what is the marriage are of candida sp

A

35%

commonset cause infections

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13
Q

what are some common sp of candida found in the mouth

A

albicans (.90%)
glabrata (15-20%)
diff resistant natural systems

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14
Q

what si the structure of c albicans

A

oval budding
blastophores
pseudohyphae

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15
Q

what are chlamydospores

A

formed from c albicans

forms round thick walls resting structures

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16
Q

where does c albicans colonise

A

mouth
GI treat
skin
female genital tact

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17
Q

what superficial candidosis

A

pseudomembranous candidosis PMC

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18
Q

what is the superficial candidiasis mucosal infection

A

thrush
white pseudomem on buccal mucosa/vagina
easily removed by wipe
common in woman

19
Q

what are some other ski infections assc with superficial candidosis

A

intertrigo
nappy rash
paronychia
HIV infection

20
Q

what does superificl candidosis effect

A

mainly skin nd epi surfaces

21
Q

what is the other type of candidosis

A

mucocutaneous

involve bthskina nd underlying mucosa

22
Q

what is CMC

A

chronic mucocutaneous Candidosis

23
Q

what is CMC described as

A

disease of the diseased

24
Q

what is the condition of CMC

A

rare
persistent infection o mouth
skin and mucosa involved
been with t cell def

25
Q

what are the systemic/deep infection of candidossis

A

occur in major organs following candidaemia (blood infection)
can be fatal if untreated

26
Q

what happens in systemic candidosis

A
initial reaction 
- lower resp tract 
- candidaemia 
fungi migrate 
fatal if untreated
27
Q

what are the risk factors of systemic candidiosi

A

seriously ill patients
heart sugery
long term immunosuppression or drug therapy

28
Q

what is oral candidiasis presentations

A

PMC thrush
erythematous candidosis
angular cheitits
chronic hyperplasia candidosis

29
Q

how does erythematous candidosis come about orally

A

denture wearing most common

30
Q

how treat erythematous candidosis

A

antibiotics

topical steroids

31
Q

what is seen form erythematous candisoss

A

red swollen inflamed mucosae
to area of upper denture
c albicans
treat - topical, cleaning

32
Q

what causes antibiotic ore mouth

A

suppression of normal flora
overgrow c albicans
broad spec Ab

33
Q

how would treat antibiotic sore mouth

A

topical anti fungal agents

stop admin Ab

34
Q

what is angular cheitits

A

erythema and fissures in angular oris
seen denture wearers and vitamin deficiencies
superinfection s aureus

35
Q

what is chronic hyper plastic candidosis

A

individual lesions candidate leukoplakia
white patches cannot be rubbed off
parakeratinised and hyperplasia

36
Q

what are some risk factors of candidial leukoplakia

A
denture hygiene
medications
immunosuppression
xerostomia
endocrine disfunction
moisture 
smoking 
blood disease
37
Q

what is the adherence of c albans like

A

hyphen - form more adhesive - acrylic
hydrophobic surface
sp adhesins
fibrillar annoprotein

38
Q

what are the host defences/damage of c albicans

A

secreted proteinases (SAPs)
phospholipase
conc at hyphal tip

39
Q

what is the evolution of morphology and virulence in candida

A

yeast
pseudohyphae
hyphae

40
Q

what are anti fugal agents

A

antimycotics commonly prescribed by GDP’s

41
Q

what are some anti fungal agents

A

polygenes - nystatin
imidazole - micronazole
triazole - fluconazole
antimetabolite - fluorocytosine

42
Q

what does nystatin do

A

bind to ergosterol in fungal lipid mem - make mem leaky

43
Q

what do azoles do

A

inhibitor of ergosterol formation
used systemically
resistance