M&R 1.1 - The Membrane Bilayer Flashcards

1
Q

What are the functions of the bilayer? (5)

A
  • Continuous and selective permeable barrier
  • Control chemical environment inside
  • Communication
  • Recognition
  • Signal generation in response to stimuli
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2
Q

What is the dehydrated composition of the membrane?

A
  • 40% Lipid
  • 60% Protein
  • 1-10% Carbohydrate
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3
Q

How does the hydrated composition of the membrane differ from the dehydrated composition?

A

Hydrated is 20% water

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4
Q

What is the significance of water in the Bilayer?

A
  • Bonds to Bilayer with hydrogen bonds

- Facilitates hydrophilic interactions

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5
Q

Which 3 lipids are involved in the membrane?

A
  • Phospholipids
  • Glycolipids
  • Cholesterol
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6
Q

Describe the head of a phospholipid molecule

A
  • Hydrophilic
  • Polar
  • Negative
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7
Q

Describe the fatty acid chains of a phospholipid molecule

A
  • Hydrophobic
  • Uncharged
  • Non-polar
  • Cis double bond causes a kink
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8
Q

What is the advantage of phospholipids in the bilayer?

A

Increases the fluidity therefore allowing it to be ever-changing

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9
Q

How do Glycolipids differ from phospholipids?

A

The phosphocholine moiety is replaced with a sugar group

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10
Q

What is a Glycolipid with a sugar monomer called?

A

Cerebroside

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11
Q

What is a Glycolipid with an oligosaccharide chain called?

A

Ganglioside

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12
Q

What is the advantage of the similarity between phospholipids and Glycolipids?

A

Creates a constant environment for membrane proteins

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13
Q

Describe the head group of a cholesterol molecule

A
  • Polar
  • Hydrophilic
  • Hydroxyl
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14
Q

Describe the tail group of a cholesterol molecule

A
  • Aliphatic

- Non-polar

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15
Q

Describe the conjugated ring structure of a cholesterol molecule

A
  • Planar

- Single bonds that are rigid

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16
Q

What is the significance of cholesterol molecules in the bilayer?

A
  • Form hydrogen bonds with phospholipids
  • Increases stability of the environment
  • Decreases movement therefore decreasing fluidity
  • Controls fluidity of bilayer
17
Q

How are micelles and the lipid Bilayer formed?

A

Spontaneously in water

18
Q

What are the 4 movements in the dynamics of the lipid bilayer?

A
  • Flexion
  • Rotation
  • Lateral Diffusion
  • Flip-flop
19
Q

Describe Flexion in relation to the membrane

A

Fatty acids are able to move left or right

20
Q

Describe rotation in relation to the membrane

A

Fatty acids can rotate around

21
Q

Describe lateral diffusion in relation to the membrane

A

Fatty acids are able to swap places (common)

22
Q

Describe flip-flop in relation to the membrane

A
  • Lipids move from one side to the other
  • One for one exchange
  • Rare as not thermodynamically stable