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Medical Histology > Lymphoid System- Lecture 9/30/21 > Flashcards

Lymphoid System- Lecture 9/30/21 Flashcards

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USMLE® Step 1 flashcards
1
Q

Primary lymphoid organs

A

Thymus and bone marrow

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2
Q

Secondary lymphoid organs (3)

A

MALT, lymph nodes, spleen

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3
Q

Bone marrow

A

Provide a protective environment for the development of immune competent B cells

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4
Q

Thymus

A

Provides a protective environment for the development of immunocompetent T-cells

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5
Q

Epitheliaoreticular cells

A

Supports the thymocytes, contribute to the blood thymus barrier

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6
Q

Hassall’s Corpsucles

A

Whorls of specialized epithelioreticular cells that reside in thymic medulla, poorly understood but appears to regulate T-cell development

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7
Q

Uncapsulated lymphoid organs (3)

A
  • Tonsils
  • Peyer’s patch
  • appendix
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8
Q

Encapsulated lymphoid organs (2)

A
  • Lymph nodes

- Spleen

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9
Q

Germinal center

A

Part of lymphoid nodule where the B-cells live/proliferate

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10
Q

Diffuse zone

A

Part of lymphoid that houses T-cells

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11
Q

MALT

A

Mucosa associated lymphoid tissue

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12
Q

Mucosa

A

Epithelia, surrounding connective tissue (lamina propria), muscle layer just deep to it

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13
Q

Submucosa

A

Layers underneath muscularis mucosa

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14
Q

Tonsil types

A
  • Pharyngeal
  • Palatine
  • Lingual
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15
Q

Characteristics of palatine (lingual) tonsils

A

SSNKE epithelium, deep crypts, palatine and lingual histologically indistinguishable

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16
Q

Characteristics of pharyngeal tonsil

A
  • Pseudostratified epithelia with no crypts
17
Q

Peyer’s patch

A

Lives in the mucosa/submucosa of small intestine epithelium , simple columnar epithelium

18
Q

M (microfold) cell

A

Specialized epithelia with basal invaginations and active pinocytosis to allow for maximal contact between immune cells and possible antigens

19
Q

Appendix

A

Nodules line in the mucosa

20
Q

Septa

A

In the thymus, separates the lobes of the thymus

21
Q

Blood thymus barrier

A

Any cell in thymus that recognizes and antigen is killed, so if any pathogen were to get in the cell that recognizes it would be killed

22
Q

Involuting thymus

A

Adult thymus, largely CT and Fat because inactive

23
Q

Appendix functions (4)

A
  • Immune surveillance
  • Vestigal
  • Endocrine organ
  • Reserve of gut flora
24
Q

Lymph node

A
  • Range from 1mm -several CM
  • Concentrated in neck, axilla and groin
  • Filter lymph and expose antigen
25
Q

Medullary cord

A

Loose CT, with highly cellular content

26
Q

Medullary sinus

A

Venous channel running between cords, discontinuous endothelium, traversed by reticular fibers

27
Q

Splenic cords and sinuses

A

Similar to lymph node, have blood cells in both, sinuses are not traversed by reticular fibers

28
Q

Subcapsular sinus

A

Sinus that runs just under the capsule

29
Q

Trebeculum

A

CT that supports the lymph node

30
Q

High endothelial venules

A

Lymphocyte entry only, becomes leaky during cortical reaction

31
Q

Spleen functions (6)

A
  • immune response
  • destroys damaged, senescent blood cells
  • Sequesters monocytes
  • Hematopoiesis
  • Storage of platelets
  • Recycling iron
32
Q

Red pulp

A

Where the splenic cords and splenic sinuses are

33
Q

White pulp

A

Contains the lymphatic double and the periarterial lymphatic sheath

34
Q

PALS

A

Periarterial lymphatic sheath, surrounds the central artery

35
Q

Trebecular artery

A

Surrounded by CT

36
Q

Red pulp cords

A
  • Loose CT and reticular fibers, blood enters cords first
37
Q

Red pulp sinuses

A
  • Venous channels lined by elongated discontinuous endothelial cells
38
Q

Marginal zone

A

First place that RBCs encounter WBCs of the red pulp cord

Medical Histology (19 decks)

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