Endocrine System Flashcards
Hypophysis
Another name for the pituitary gland
Pars distalis
Body of anterior lobe
Pars tuberalis
Neck of the anterior pituitary
Pars intermedia
Close to the cystic cavities
Sections of the anterior lobe of the pituitary
- Pars distalis
- pars intermedia
- Pars tuberalis
Pars nervosa
Posterior lobe of the pituitary
Parts of posterior pituitary
- Infundibulum
- Pars nervosa
Cells of the pars distalis
- Chromophobe
- Basophils
- Acidophils
Acidophiles ex (2)
- Samatotropes
- Lactotropes
Basophils ex (3)
- Corticotropes (ACTH)
- Thyrotropes (TSH)
- Gonadotropes (FSH and LH)
Folliculostellate cells
Dentdritic morphology devoid of granules, paracrine regulation and immune regulation
Pars intermedia secretions (3)
- MSH (melanin stimulating hormone)
- B-endorphin
- ACTH
Pituitary portal system
Runs from hypothalamus to anterior pituitary
Posterior pituitary hormones (2)
ADH
Oxytocin
herring bodies
Formed by pituicytes, storage for neurohormones
Oxytocin function
- Smooth muscle contraction
- Myoepithelial cell contraction 9mammary)
- Emotional
ADH (vasopressin) function
Increases permeability of collecting duct
Pineal gland secretion
Melatonin
Pineal gland cycles
Inhibited by light (norepinephrine) inhibited by dark
Corpora arencea
Brain sand, large calcification in pineal gland
Myeloconia
Brain dust, small calcification
Islet hormones
-Insulin
-Glucagon
_Somatostatin
-Pancreatic polypeptide
-Ghrelin
Alpha islet cell
secreted glucagon
Beta islet cell
Insulin (inside)
Thyroglobulin
Iodinated glycoprotein, comprises the major colloid components
Thyroxine
T4, most abundant form in blood, less active
Triiodothyronine
T3, less abundant, more active
Resorption lacunae
Sign of an active thyroid, blank spots in the colloid
Goiter
Hypertrophy and hyperplasia of the thyroid cells
Graves’ disease
Autoantibodies against the TSH receptor, hyperthyroidism, goiter develops from hyperplasia
Parafollicular, clear cells
Releases calcitonin
Calcitonin
Stimulated by high Ca2+, lowers blood calcium levels by reducing Osteoclast activity, increasing Osteoblast activity, decreasing Ca2+ absorption
Chief cells,
Secrete PTH
PTH
Increases blood calcium, increases Osteoclast activity, stimulates Vitamin D activation
Oxyphil cells
- appear at puberty
- unknown function
Ectopic thyroid
Thyroid where its not supposed to be
Three layers of adrenal gland
Zona Glomerulosa
Zona Fasciculata
Zona reticularis
Zona glomerulosa
Most superficial layer, secretes mineralcorticoids (aldosterone)
Zona Fasciculata
Middle layer, secretes glucocorticoids (cortisol)
Zona reticularis
Deepest layer, secretes androgens, precursor for sex hormones
Adrenal medulla
Neural crest derived, synthesize catecholamines (epinephrine or norepinephrine)
Chromaffin cells
Neuroendocrine cells, modified axons, under parasympathetic control