Liver, Gallbladder, And Pancreas Lecture 10/13/21 Flashcards
Liver function (3)
- Metabolic
- Exocrine
- Endocrine
Liver blood flow
Input-> Portal vein and hepatic artery
Output-> Hepatic veins to inferior vena cava to heart
Central vein
Where sinusoids drain into
Portal triad
Portal vein
Hepatic artery
Bile duct
Direction of flow of blood/bile
Blood flows through sinusoids to the central vein
Lymph is generated in hepatocytes and drains toward bile duct
Liver lobules
Hexagonal arrangement with central vein at the center
Hepatic acinus
Oval between two central veins
Kupffer cells
Liver macrophages, derived from monocytes
Ito cells
Store vitamin A, generate scar tissue
Bile canaliculus
Sealed by tight junctions between hepatocytes, involved in bile secretion
Sinusoidal domain
Lines the sinusoid, full of microvilli, space of disse
Space of disse
Peri sinusoidal, lined with reticular fibers to slow flow
Gallbladder layers
Simple columnar epithelium
Lamina propria
Muscularis (irregular)
Serosa/Adventitia
Pancreas structure
Lobular with septa separating lobules
Serous acini
Orange like look with apical eosinophilic secretion