Lymphatic System and Immunity Flashcards
- The ability to fight off pathogens and prevent disease.
- Uses a combination of physical, chemical, and cellular defenses to maintain health.
immunity
2 main types of immunity
- innate immunity
- adaptive immunity
type of immunity
* present at birth
* immediate response
* general protection
Innate immunity
type of immunity:
* develops after exposure to specific pathogens
* slower but precise
* involves learning to recognize and remember pathogens for future defense
adaptive immunity
Present at birth, rapid response
* First line of defense:
* Skin and mucous membranes
* Second line of defense:
* Antimicrobial substances, inflammation, fever
* Components: Phagocytes, natural killer cells, complement system, interferons
Innate immunity
3 physical barriers
- Skin and mucous membranes
- Mucous membranes
- Cilia and mucus
First line of defense, blocking pathogen entry
skin and mucous membranes
traps microbes (physical barrier)
mucous membranes
expels microbes
cilia and mucus
3 internal defenses
- phagocytes (like macrophages)
- natural killer cells
- fever
Internal defense: engulf and destroy pathogens
phagocytes (like macrophages)
Internal defense: destroy infected or cancerous cells
natural killer cells
Internal defense: raises body temperature to inhibit microbial growth
fever
4 antimicrobial substances
- interferons
- complement system
- iron-binding proteins
- antimicrobial peptides
Antimicrobial substance (EXAM): proteins that prevent viral replication
interferons
Antimicrobial substance (EXAM): enhances immune response, leading to pathogen lysis
complement system
Antimicrobial substance (EXAM): reduce iron availability to microbes
iron-binding proteins
Antimicrobial substance (EXAM): directly kill microbes
antimicrobial peptides
2 key mechanism of innate immunity
- inflammation
- fever
body’s nonspecific response to tissue damage
inflammation
- increases interferon effectiveness
- inhibits microbial growth
- speeds up body reactions
fever
- localized response to infection or injury
- helps recruit immune cells to the side of damage
- increase blood flow and permeability
- cardinal signs: redness, swelling, heat, and pain
purpose of inflammation
- responds to specific microbes
- antigens
- two types
adaptive immunity
foreign substances triggering immune response
antigens
2 types of adaptive immunity
- cell-mediated immunity
- antibody-mediated immunity
type of adaptive immunity: T cells directly attack invaders
cell-mediated immunity
type of adaptive immunity: B cells produce antibodies
Antibody-mediated immunity
2 functions of the lymphatic system
A. Fluid balance and Lipid transport
B. Immune response
How does the lymphatic system maintain fluid balance and lipid transport?
- drains excess interstitial fluid
- transports dietary lipids
Fluid Balance and Lipid Transport: prevents tissue swelling by returning fluid to the bloodstream
drains excess interstitial fluid
Fluid Balance and Lipid Transport: fats absorbed from the digestive system are carried by the lymph
transports dietary lipids
Function of the lymphatic system that carries out immune responses by filtering harmful substances from lymph
immune response
- Develop in bone marrow, produce antibodies
- Produce antibodies
B cells
- Mature in the thymus, involved in cell-mediated immunity
- Attack infected cells directly
T cells
- A clear fluid similar to blood plasma. It circulates through the lymphatic vessels.
lymph
Thin-walled structures that transport lymph throughout the body
lymphatic vessels
Filter lymph and house immune cells like B and T cells
lymph nodes (Tagalog: kulani)
Aside from lymph, lymphatic vessels, and lymph nodes, what are the other components of the lymphatic system?
thymus, spleen, and lymphatic nodules
- Small, blind-ended vessels that absorb interstitial fluid.
- (start as closed-ended structure)
Lymphatic capillaries
_____ and ______ drain lymph into the bloodstream, returning it to circulation.
Thoracic duct and right lymphatic duct
Which areas does the right lymphatic duct drain?
- The right side of the head and
neck (right side of the face and
scalp). - The right upper limb (arm).
- The right side of the thorax
(chest), including the right lung, right side of the heart, and part of
the liver.
Which areas does the right lymphatic duct empties? (EXAM)
The right lymphatic duct drains into the venous system at the junction of the right internal jugular vein and the right subclavian vein.
Which areas does the thoracic duct drains?
- The entire left side of the body (left side of the head and neck, left upper limb, and left thorax).
- The entire lower body (both legs, pelvic region, and abdomen)
The thoracic duct empties where? (EXAM)
The thoracic duct drains into the venous system at the junction of the left internal jugular vein and the left subclavian vein.
● In tissue spaces between cells
● Merge to form larger lymphatic vessels
Lymphatic capillaries
● Empties its lymph to left internal jugular and left subclavian veins
Thoracic duct
- empties its lymph into the right internal jugular and right subclavian veins.
● Thus, lymph drains back into the blood.
Right lymphatic duct
Two pumps aid in lymph movement
○ Skeletal muscle pump
○ Respiratory pump
______ helps circulate immune cells to areas of infection or injury.
Lymphatic flow
consists of Red bone marrow and thymus, where lymphocytes mature.
Primary lymphatic organs
Lymph nodes, spleen, and lymphatic nodules, where immune responses are activated.
Secondary lymphatic organs
Where are red bone marrows found?
Mostly flat bones, and long bones
- Located in flat bones and long bone ends.
- Produces mature B cells and immature T cells.
red bone marrow
- Immature T cells migrate to the ________ to mature into functional T cells
thymus
These are sites where most immune responses occur.
Secondary lymphatic organs
Concentrated near mammary glands, axillae, and groin.
lymph nodes
the largest mass of lymphatic tissue
spleen
egg-shaped masses of lymphatic tissue
lymphatic nodules
- A two-lobed organ located:
§ Posterior to the sternum
§ Medial to the lungs
§ Superior to the heart
o Contains large numbers of T cells and macrophages.
Thymus
○ Located at intervals along lymphatic vessels
○ Masses of B cells and T cells surrounded by a capsule
○ Lymph flows through______
lymph nodes
o Located along lymphatic vessels
o Concentrated in certain areas (mammary glands, axillae, groin).
lymph nodes
§ Filter lymph and activate immune responses.
§ Contain B cells, T cells, dendritic cells, and macrophages.
Lymph nodes
- contain B cells, T cells, and macrophages
- Lymph flows through ____, where foreign substances are filtered and destroyed.
lymph nodes
____ bring lymph into nodes
Afferent vessels
_____ allow lymph to exit
Efferent vessels
- The ___ is the largest lymphatic organ, located between the stomach and diaphragm.
- nonpalpable
-
graveyard of RBC
o Functions (production):
§ White Pulp
§ Red Pulp
spleen
- Contains lymphatic tissue where immune responses take place.
white pulp
Removes worn-out blood cells and platelets and stores platelets
red pulp
In the two pump aid, “as long as it is moving, it will pour out lymph (ex. exercise); voluntary
Skeletal muscle pump
In the two pump aids, it “moves lymph and immune cells as we breath”; involuntary
respiratory pump
This lymphatic organ is large at birth, and gets small (decrease in function) at adolescence
Thymus
_______ is where lymphocytes mature, and _ is where immune responses are activated
Primary lymphatic organs, secondary lymphatic organs
- Egg-shaped masses of lymphatic tissue
o Not surrounded by a capsule
o Located in mucous membranes lining the GI, urinary, reproductive, and respiratory tracts
Lymphatic nodules
- Specific responses tailored to pathogens.
- T cells and B cells are central to this system.
- T cells attack infected cells.
- B cells produce antibodies that neutralize invaders.
adaptive immunity
- Substances recognized as foreign by the immune system
- Ex: microbes, pollen, drugs
antigens
The _____ generates specific responses to each antigen via clonal selection of T and B cells.
immune system
Process where lymphocytes multiply to fight a specific antigen
clonal selection
In lymphocyte proliferation:
* Actively fight infection.
effector cells
Stay in the body to quickly respond if the antigen returns
memory cells
Activate B cells and cytotoxic T cells.
helper t cells
Destroy infected cells directly
cytotoxic t cells
are crucial for attacking cells that are infected with viruses or intracellular pathogens
t cells
This activates the cytotoxic t cells
helper t cells
- In ____ (disease), it attacks helper t cells
transmitted by sex, blood-borne, or vertical transmission (mother-daughter genetics)
cripples the immune system*
HIV
Transform into plasma cells, which produce antibodies.
b cells
- Bind to antigens, neutralizing pathogens
- Marking pathogens for destruction by other immune cells
antibodies
5 types of immunoglobulins (EXAM)
IgG, IgA, IgM, IgD, IgE
Immunoglobulin: Most common, provides long-term immunity (EXAM)
IgG
Immunoglobulin: Found in mucous membranes (EXAM)
IgA
Immunoglobulins, it first produced during an immune response (EXAM)
IgM
Involved in B cell activation (EXAM)
IgD
Associated with allergic reactions (EXAM)
IgE
- Persist after an infection
- Allow for a faster and stronger response if the same antigen is encountered again.
- This is the basis of vaccinations
memory cells
introduces a harmless form of an antigen to stimulate the production of memory cells.
vaccination
____ leads to a decline in immune function
Aging
- _____ individuals are more susceptible to infections and malignancies.
- ____: With age, the body may
produce antibodies that attack its own cells,
leading to autoimmune conditions
Elderly , autoantibodies