Lymphatic/Immune Flashcards
purpose of lymphatic system
absorb fat & fat-soluble vitamins thru lacteals, remove waste & destroy pathogens, return filtered lymph to veins
define LEUKOCYTE
white blood cell
define MUCOUS
adjective describing specialized membranes that line body cavities
define MUCUS
noun; fluid secreted by mucous membranes
define LACTEALS
specialized structures that absorb fats that can’t go thru blood & transforms them to be put in blood
describe INTERSTITIAL FLUID
plasma from arterial blood from arterioles to capillaries flowing into spaces between cells of tissues that deliver nutrients, O2, & hormones & bring waste & protein when leaving; 90% returning fluid
interstitial fluid is also known as
intercellular or intertissue fluid
describe LYMPH
10% return fluid that is not interstitial fluid; clear, faintly yellow & watery w/electrolytes & proteins; remove dead cells, debris, & pathogen
define LYMPHATIC CIRCULATORY SYSTEM
upward movement, fluid filtered by lymph nodes & depend on pumping motion of muscles to move liquid
aka: lymph
lymphatic fluid
aka: lymphatic circulatory system
secondary circulatory system
describe LYMPHATIC CAPILLARIES
microscopic, sealed on 1 side & tubes near surface; separate to bring lymph & close to push up & forward
define LYMPHATIC VESSELS
vessels deep in tissue w/valves to prevent backflow & form ducts to drain
describe RIGHT LYMPHATIC DUCT
right side of head & neck, upper right body quadrant & right arm; empty into right subclavian vein
thoracic duct
largest lymphatic vessel; left side of head & neck, LUG, left arm, lower trunk, legs’ empty into left subclavian vein
describe LYMPH NODES
lymphocytes destroy harmful stuff in lymph & filter to rejoin circulation; 400-700 in body in 3 groups (cervical, axillary, & inguinal)
define LYMPHOCYTES
leukocytes formed in bone marrow as stem cells that defend against antigens
aka: lymphocytes
lymphoid cells
define NATURAL KILLER CELLS
lymphocytes kill cancer/infected cells
define B CELLS
lymphocytes deal w/humoral immunity & immunoglobulins
aka: b cells
b lymphocytes
define HUMORAL IMMUNITY
turn plasma cells & secrete immunoglobulins
define IMMUNOGLOBULINS
antibody destroy antigen & then turns into plasma cell to secrete antibodies
define T CELLS
help in cell-mediated immunity
aka: t cells
T lymphocytes
describe CYTOKINES
group of proteins released by T-cells to act as intracellular signals for immune response; types = cytotoxic, helper, natural killer
define INTERFERONS
made in response to antigens to activate immune system, slow/stop virus multiplication, & signal cells to increase defense
define INTERLEUKINS
direct B & T cells to divide & proliferate (+ other stuff)
components of cell-mediated immunity
interleukins, interferons, cytokines
define CYTOTOXIC CELLS (T8)
attach to antigens & destroy
define HELPER CELLS (T4)
aid B cells to recognize antigens & stimulate antibody production
define NATURAL KILLER CELLS (NK cells)
target pathogenic cells (viruses & cancers) by recognizing sugars
describe TONSILS
3 masses of lymphoid tissue in protective ring to stop pathogens to respiratory from nose & mouth (adenoids, palatine, lingual)
describe THYMUS
mass of lymphoid above heart that stimulates lymphocytes into T cells; biggest @ puberty & shrinks w/age
define VERMIFORM APPENDIX
mass of lymphoid tissue that hangs from lower part of cecum
define SPLEEN
sac-like mass of lymphoid tissue in LUQ inferior diaphragm & posterior stomach
purpose of spleen
filters microorganisms & foreign from blood; forms lymphocytes & monocytes; destroyes RBCs; store extra RBCs & maintain balance between plasma & RBCs
define ANTIGEN-ANTIBODY REACTION
bind antigen to antibodies so immune can recognize & destroy
aka: antigen-antibody reaction
immune reaction
define TOLERANCE
acquired unresponsiveness to specific antigen or decline in responsiveness to drug
describe IMMUNOGLOBULINS
bind w/specific antigens in antigen-antibody response; types = G, A, M, D, E
describe IgG
most abundant & main defense; blood & lymph; fight bacteria, fungus, viruses, & foreign particles; 75% all Ig; only one that can cross placenta
describe IgA
gen against ingested antigens; bodily secretions/fluids; prevent attachment of virus & bacteria to epithelial surface
define IgM
in circulating bodily fluids & 1st to appear in response to exposure
define IgD
only on surface of B cells & important in B cell activation
define IgE
made in lungs, skin, mucous membranes & responsible for allergic reactions
describe PHAGOCYTES
specialized leukocytes part of antigen-antibody that destroys cell debris, dust, pollen, & pathogens; types = monocytes, macrophage, dendritic cells, mast cells
define MONOCYTES
leukocytes w/immunological defenses & become macrophages & dendritic cells after leaving bloodstream
define MACROPHAGE
leukocyte surround & kill to remove dead cells & stimulate immune cells
describe DENDRITIC CELLS
specialized leukocytes patrol body; grabs & swallows & alerts B & T cells
describe COMPLEMENT SYSTEM
group of proteins circulate blood when inactive; together w/antibodies dissolve & remove pathogenic bacteria & foreign cells
describe IMMUNITY
state of being resistant to disease; natural/passive (since birth/breast milk) & acquired (have had disease/vaccine)
describe MYCOSIS
any abnormal condition/disease bc of fungus
describe LYMPHADENITIS lymphadenitis
inflammation of lymph nodes gen indicating infection
aka: lymphadenitis
swollen glands
define LYMPHADENOPATHY
any disease affecting lymph nodes
describe LYMPANGIOMA
benign tumor from weird collection of lymphatic vessels bc congenital malformation of lymphatic system
define RUPTURED SPLEEN
covering of spleen torn
describe LYMPHEDEMA (LE)
swelling form abnormal accumulation of lymph fluid in tissues bc of damage to system; associated w/infections
define ALLERGIC REACTION
immune system reacts to harmless allergen
aka: allergy
hypersensitivity
define ALLERGY
overreaction to particular allergen
define LOCALIZED ALLERGIC RESPONSE localized allergic response
redness, itching, & burning after allergen contact
aka: localized allergic response
cellular response
define SYSTEMIC REACTION
anaphylaxis/anaphylactic shock
define ANAPHYLAXIS
severe & potentially fatal allergic reaction w/hives, difficulty breathing, nausea, vomiting, shock
describe AUTOIMMUNE DISORDERS
immune system makes antibodies against own; genetic & predominant in childbearing age women
define IMMUNODEFICIENCY DISORDER
missing/deficient in +1 part of immune response
describe SEVERE COMBINED IMMUNODEFICIENCY (SCID)
rare & inherited; high susceptibility to infection & failure to thrive
describe HUMAN IMMUNODEFICIENCY VIRUS (HIV)
blood-borne infection of virus that damages/kills T cells leading to progressive failure making patient very susceptible for life-threatening infections
define ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS)
most advanced & fatal stage of HIV
define OPPORTUNISITIC INFECTION
pathogen able to cause infection when host weak but otherwise not able to when patient healthy
describe KAPOSI’S SARCOMA
opportunistic infection associated w/HIV; cancer causing patches of red/purple abnormal tissue under skin, lining of mouth/nose/throat, in organs
describe ANTHRAX
contagious disease transmit thru livestock infected w/bacillus anthracis
describe SHIGELLOSIS
infection caused by shigella leading to diarrhea & fever; prevent w/good hygiene
describe LYME DISEASE
transmit via tick bite that bit infected deer w/spirochete Borrelia burgdorferi; s/s: fever, headache, fatigue, skin rash
define TINEA PEDIS
fungal infection between toes
aka: tinea pedis
athlete’s foot
aka: Candidiasis
yeast infection
describe GIARDIASIS
diarrheal disease from Giardia transmitted thru feces contaminated H2O
describe MALARIA
parasite in mosquitoes to humans; s/s: fever, shaking, chills, headache, muscle aches, & fatigue
describe TOXOPLASMOSIS
condition from parasites from pets to ppl via contaminated feces; pregnant ppl avoid
describe EBOLA
rare & generally fatal; transmit w/any bodily fluid w/virus & only when symptoms present; s/s: high fever, vomiting, diarrhea, internal bleeding, & organ failure
describe MEASLES
acute, highly contagious infection transmitted via respiratory droplets w/rubeola virus; s/s: red, itchy rash over body/high fever/runny nose/coughing/hearing loss/bronchitis
define MUMPS
acute viral infection w/swelling of parotid glands & gonads
describe RUBELLA
viral infection gen not severe/long very serious for women in early pregnancy; s/s: low fever, swollen glands, inflamed eyes, fine pink rash
describe RABIES
acute viral infection thru bite/saliva of infected
describe WEST NILE VIRUS
spread via infected mosquito bite; mild (flu like) or severe (spread to brain & spine)
describe ZIKA VIRUS
spread via infected mosquito bite, mom to baby, sex; s/s: fever, rash, birth defects
describe CYTOMEGALOVIRUS
found in most bodily fluids; silent infection until weakened immune or mom to baby; can cause serious congenital disabilities to baby
define VARICELLA
fever & rash w/itchy fluid-filled blisters
aka: varicella
chicken pox
describe HERPES ZOSTER
acute viral infection w/painful rash along torso along inflamed peripheral nerve bc of reactivated varicella virus
aka: herpes zoster
shingles
describe INFECTIOUS MONONUCLEOSIS
caused by Epstein-Barr virus in teens & YA; s/s: fever, sore throat, enlarged lymph nodes, spleen swelling, liver involvement; spread via saliva
aka: infectious mononucleosis
monon
describe ROSEOLA
common infants 6 months-2yrs; s/s: high fever & rash
aka: roseola
sixth disease
define NEOPLASM
tumor
define LEIOMYOMA
benign tumor of smooth muscle
define LEIOMYOSARCOMA
malignant tumor of smooth muscle
define RHABDOMYOMA
benign tumor of striated muscle on/in smooth muscle of heart
define RHABDOMYOSARCOMA (RMS)
malignant tumor of skeletal muscle
define MYOSARCOMA
malignant tumor from muscle
define CARCINOMA
malignant tumor occurring in epithelial
define CARCINOMA IN SITU
in og position & not disturbing/invading
define ADENOCARCINOMA
any 1 of large group of carcinomas from glandular/mucus secreting tissue (pancreas, lung, prostate, colon, esophagus)
define SARCOMAS
malignant tumor from connective (hard & soft)
define OSTEOSARCOMA
hard-tissue sarcoma gen w/upper shaft of long bones/pelvis/knee
define LYMPHOMA
gen term for malignancies affecting lymphoid tissues
describe HODGKIN’S LYMPHOMA (HL)
large, cancerous lymphocytes that compromise immune; spleen, liver, bone marrow, lymph nodes
describe NON-HODGKIN’S LYMPHOMA (NHL)
more common than HL; any lymphoma except Hodgkin’s, origin @ lymphocytes
describe DUCTAL CARCINOMA IN SITU (DCIS)
earliest stage of breast cancer before abnormal cells break thru milk duct walls; cancerous or benign
describe INFILTRATING DUCTAL CARCINOMA (IDC)
breast cancer starts in milk duct & invades fatty breast outside duct; most common
describe INFLAMMATORY BREAST CANCER (IBC)
rare & aggressive; cancer blocks lymphatic vessels in skin of breast; s/s: pain, rapid increase in breast size, redness, rash, swelling of nearby lymph nodes
define LYMPHOSCINTIGRAPHY
detect damage or malformations of lymphatic vessels w/radioactive substance into ducts & follow w/scanner or probe
define BIOIMPEDANCE SPECTROSCOPY
noninvasive way to diagnose lymphedema by measuring resistance to electrical current thru affect limb
define ENZYME-LINKED IMMUNOSORBENT ASSAY (ELISA)
blood test to screen for HIV antibodies, lyme disease, & other conditions
define MOLECULAR BREAST IMAGING (MBI)
nuclear medicine w/gamma radiation to detect potential breast cancer
define BREAST MRI
w/magnets, radio waves, & contrast
define CORE NEEDLE BIOPSY
hollow needle to collect samples
define SURGICAL BIOPSY
tissue collected bigger than tissue
define LYMPH NODE DISSECTION
all lymph nodes in major area removed to determine or slow cancer
define CULTURE & SENSITIVITY (C&S)
specimens put in growth medium & observed for bacterial reproduction
define IMMUNOELECTROPHORESIS
measures immunoglobulins based on differences in electrical charge & reactivity
define SEROLOGY
any variety of tests that screen blood for antigen-antibody reactions to show presence of infection/disease
define ANTIANGIOGENESIS
treatment disrupts blood supply to tumor
define ANTIHISTAMINES
relieve/prevent symptoms of allergy & prevent effects of histamine
define IMMUNOTHERAPY
stimulate/repress immune response
aka: immunotherapy
biological therapy
define SYNTHETIC IMMUNOGLOBULINS
post-exposure preventive against certain viruses (rabies & hepatitis)
aka: synthetic immunoglobulins
immune serum
define SYNTHETIC INTERFERON
use in treatment of MS, hepatitis C, & cancers
describe MONOCLONAL ANTIBODIES
any antibodies made in lab by identical offspring of clone of cells to artificially produce antibodies to enhance immune; treat non-Hodgkin’s lymphoma, melanoma, breast cancer, colon cancer
describe HIV TREATMENT
antiretroviral therapy (ART) treatment regimen; cocktail of drugs
define IMMUNOSUPPRESSANT
prevent/reduce normal immune response to prevent rejection of transplants & depress autoimmune disorders
define CORTICOSTEROID DRUG
synthetic hormone closely resembling cortisol
describe CYTOTOXIC DRUG
medication kill/damage cells; used as immunosuppressant/antineoplastic
define BACTERICIDE
substance that kills bacteria
define HOMRONE THERAPY
can treat Er & PR positive breast cancers
define LUMPECTOMY
remove tumor & other abnormal tissue of breast & good margins
aka: lumpectomy
partial mastectomy or breast-conserving surgery
describe MASTECTOMY
surgical removal of part/all breast & nipple & sometimes axillary lymph nodes; can spare skin & nipple; done if tissue diseased
aka: mastectomy
total or simple mastectomy
define MODIFIED RADICAL MASTECTOMY
surgical removal of entire breast & all/some axillary lymph nodes of adjacent arm
describe RADICAL MASTECTOMY
surgical removal of entire breast tissue, chest muscles, & lymph nodes; rare cases for breast cancer
define SIMPLE MASTECTOMY
surgical removal of entire breast tissue w/o touching lymph nodes
define CHEMOTHERAPY
use chemical agents & drug cocktails
define CHEMOPREVENTION
use natural/synthetic substances to reduce risk of developing/redeveloping cancer & reduce size/slow tumor development
describe ANTINEOPLASTIC
meds block development/growth/proliferation of malignant cells; common cancer treatment
define BRACHYTHERAPY
use radioactive materials in contact w/or implanted target tissues
define TELETHERAPY
radiation therapy from distance
describe TOMOTHERAPY
combo of tomography w/radiation therapy leading to precise target; radiation delivered slice by slice
define TARGETED THERAPY
develop form of anticancer to identify & attack specific cancer w/o harming other cells
describe ADJUVANT THERAPY
sometimes done after primary treatment; include chemotherapy, hormone therapy, radiation, immunotherapy, & targeted therapy
define CLINICAL TRIALS
involve testing new & promising cancer treatments w/o FDA approval for research
define ANTIBODY THERAPY
synthetic immunoglobulins, interferons, or immunodeficiency disease
define BACILLI
rod shaped spore forming bacteria
define RICKETTSIA
small bacterium living in lice, fleas, ticks, & mites
define SPIROCHETES
long, slender, spiral shaped bacteria w/flexible walls & can move
describe STAPHYLOCOCCI
group of 30 species of bacteria forming irregular clusters like grapes; most harmless & in skin & mucous membranes but some can lead to infection
define STAPHYLOCOCCUS AUREUS
infects wounds, toxic shock, food poisoning
aka: staphylococcus aureus
staph aureus
describe STREPTOCOCCI
bacteria forming chain; many harmless but some cause disease
describe METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA)
bacteria resistant to most antibiotics so infection becomes more serious, difficult to treat, & fatal; s/s: small, red bumps w/black tops become abscesses
define FUNGUS
simple parasitic organism that is harmless or pathogenic
define YEAST
type of fungus
define PARASITE
plant or animal living on or within another @ expense of host
define VIRUSES
very small infectious agents that invades cells & reproduce in cells
define MMR VACCINE
measles, mumps, & rubella vaccine given in early childhood
define ANGIOGENESIS
process tumor supports growth by making own supply
define STAGING
classifying tumors by progression, response to therapy & prognosis