Lecture Two - Skin Flashcards

1
Q

Skin accessory structures

A
  • hair
  • sweat glands
  • receptors
  • nails
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2
Q

Where is hair found

A

All over the body except palms, soles and lips

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3
Q

What is hair made of?

A

Made of dead, keratinised cells produced inside a hair follicle
- hair shafts projects from the follicle

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4
Q

Accessory structures - hair

A
  • arrector pili muscle
  • root hair plexus
  • sebaceous glands
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5
Q

What does the arrector pili muscle do?

A
  • contraction produces ‘goose bumps’
  • improves insulation
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6
Q

What is the root hair plexus and what does it do?

A
  • a collection of sensory nerves at the base of each hair follicle
  • heightened sensation
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7
Q

What do the sebaceous glands do?

A
  • produce oily secretion called sebum
  • nourished hair shaft and naturally moisturises skin
  • water repellent
  • blocked hair follicles + infecutoion due to increase sebum production leads to acne
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8
Q

What does increased sebum production do

A
  • results in blocked hair follicles and infection leading to acne
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9
Q

What is lanolin?

A
  • sheep sebum
  • purified and used commercially in skin care products
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10
Q
A
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11
Q

Where are eccrine sweat glands found?

A
  • found in most areas of the skin
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12
Q

What do eccrine sweat glands do?

A
  • pour watery secretions directly onto the skin surface
  • important in thermoregulation and excretion
  • some antibacterial action
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13
Q

Where are apocrine sweat glands found?

A
  • found in specific areas
    E.g: armpit, groun and around nipples
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14
Q

What do apocrine sweat glands do?

A
  • secrete sticky/oily and at times potentially odorous secretions into the base of the hair follicle
  • influences by hormones e.g lactation
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15
Q
A
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16
Q

Receptors

A
  • tactile
  • lamellar
  • bulbous
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17
Q

What do nails do?

A
  • protect fingertips / toes
  • enhance sensation
  • sensory receptors require deformation
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18
Q
A
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19
Q

How does skin anatomy relate to its function ?

A
  • aging
  • pigmentation
    • protection from UV radiation (high pigmentation)
    • vitamin D production (low pigmentation)
  • skin cancer / vitamin D insufficiency
  • tattoo (artificial pigmentation)
20
Q

Skin aging

A
  • thin epidermis
  • thin dermis (sagging/wrinkling) - reduced collagen
  • slower skin repair
  • drier epidermis (less sebum)
  • impaired cooling (less sweat)
  • less pigmentation (pale skin, grey hair)
21
Q

Smoking and skin aging - tobacco

A
  • contains agents that accelerate aging
  • damages collagen and elastin in the skin
  • linked with poor wound healing, acne, skin and oral cancers
22
Q

Vaping and skin aging

A
  • contains nicotine
  • nicotine reduces blood circulation in the dermis
  • contact? Dermatitis (skin inflammation) due to metal coating on e-cigarettes
23
Q

Difference betweeen a mole and a freckle

A

Mole:
- cluster of melanocytes
- over proliferation can be caused by sun exposure

Freckle:
- melanocytes overproducing melanosomes
- over produciotn triggered by sun exposure

24
Q

Skin _____ matches ____ exposure

A

Skin pigmentation matches UV exposure ( in indigenous populations)

25
Q

Vitamin D is essential for…

A
  • normal calcium metabolism
  • strong bones
26
Q

Vitamin D diffieicny causes …

A
  • rickets
  • affects mood
27
Q

What is required for vitamin D synthesis

A
  • UV exposure in skin

This explains the greater incidence of lightly pigmented skin at higher latitudes

28
Q

Who is more susceptible to vitamin D dificiency ?

A

Highly pigmented people are more susceptible to vitamin D deficiency, particularly at extreme latitudes

29
Q

Why NZ has one of the highest rates of skin cancer world wide… why?

A
  • large European population
  • intense UV (elliptical orbit of sun, latitude, thin Ozone)
  • Australia is similar
30
Q

What absorbs UV light? And what does it result in?

A

Melanin pigment absorbs UV light, protecting cells from UV damage

31
Q

Where is melanin produced?

A

In melanocytes (cells)

32
Q

How is melanin pigment transferred to epidermal cells?

A

Melanin pigment is transferred to epidermal cells by melanosomes (vesicles containing melanin)

33
Q
A
34
Q
A
35
Q

Where are melanocytes found

A

Melanocytes are only found in the stratum basale - they are not shed

36
Q

Where are melanosomes found

A

Melanosomes are found throughout the epidermis - is shed with keratinocytes

37
Q

Desity of melanocytes ?

A

Varies throughout the body and through time

38
Q
A
39
Q

Basal cell carcinoma

A
  • common but relatively benign
  • originates in stratum basale (gets moved away from blood stream via epidermis shedding)
  • metastasis (spread) is rare
40
Q

Malignant melanoma

A
  • rare but deadly if not treated
  • originates in the melanocytes (pigmented)
  • highly metastatic
  • mortality rate dependent upon tumour
41
Q

The thickness of melanoma highly correlates with mortality rate

A
42
Q

Tattoo and how it relates to skin anatomy

A

Artificial pigmentation (usually ink) deposited deep within the skin
- dermal layer, i.e - not shed
- captured (but not broken down) inside immune cells/scar tissue
- ‘Lena’ tattoo, pigmentation of lymph nodes

43
Q

Pigment in lymph nodes =

A

Tattoo
Not melanoma

44
Q

Types of tattoo

A
  • trauma
  • decorative
  • cosmetic tattoos
45
Q

Tattoo Polynesian connection

A
  • Māori, ta moko
  • Samoan, Pe’a
46
Q

Skin is composed of…

A

All four basic tissue types:
Epithelial, muscular, nervous and connective