Lecture 8- Cerebrospinal Fluid and the Blood Brain Barrier

Question 1

Which ventricle is located around the thalamus

Answer 1

III

Question 2

Which ventricle is located between the brainstem and cerebellum?

Answer 2

IV

Question 3

Where is CSF produced?

Answer 3

Choroid plexus

Question 4

What is CSF composed of?

Answer 4

Ultra-filtered blood, few lymphocytes, and a small amount of protein

Question 5

What direction does CSF flow?

Answer 5

Cranial to caudal (lateral vent –> III –> cerebral aqueduct –> IV

Question 6

What is the most common location of a CSF block?

Answer 6

Cerebral aqueduct

Question 7

What reabsorbs CSF?

Answer 7

Arachnoid villi

Question 8

Functions of CSF-

Answer 8

Protection, pressure regulation, nourishment/waste removal, chemical buffer

Question 9

What disease causes dilation of the ventricular system?

Answer 9

Hydrocephalus

Question 10

What is a ventriculoperitoneal shunt used to treat?

Answer 10

Hydrocephalus

Question 11

Components of the BBB

Answer 11

Tight junctions, endothelial cells (blood side), basement membrane, astrocytes (brain side)

Question 12

For CNS inflammation, you must chose abx that can…

Answer 12

Cross the BBB