Lecture 46- Liver Physiology

Question 1

What percent of blood supply to the liver comes from the hepatic artery

Answer 1

25%

Question 2

What is on the outside of the liver lobule in the portal triad?

Answer 2

the portal vein, hepatic arteriole, and bile duct

Question 3

Does bile from away from or towards the portal triad?

Answer 3

towards (opposite of blood)

Question 4

What is analogous to a lobule, but the portal triads on on the middle

Answer 4

Liver acinus

Question 5

What percent of the cardiac output is within the liver at any time?

Answer 5

30%

Question 6

What are macrophages called within the liver?

Answer 6

Kupffer cells

Question 7

What does the liver do to amino acids?

Answer 7

Deamination

Question 8

Where are plasma proteins made?

Answer 8

The liver

Question 9

Where are coagulation factors produced

Answer 9

THe liver

Question 10

How is bilirubin made

Answer 10

Breakdown of RBCs

Question 11

What protein shuttles unconjugated bilirubin in the blood stream

Answer 11

Albumin

Question 12

What conjugates bilirubin to secrete it in bile

Answer 12

Glucuronic acid

Question 13

What is the process of heme degredation

Answer 13

Heme -> biliverdin by heme oxygenase -> bilirubin by biliverdin reductase

Question 14

What happens to bilirubin in the colon

Answer 14

It is converted to urobilinogens by bacteria

Question 15

Causes of pre-hepatic bilirubinemia

Answer 15

RBC destruction

Question 16

Causes of hepatic bilirubinemia

Answer 16

liver shunt, no conjugation, bile duct obstruction

Question 17

Causes of post hepatic bilirubinemia

Answer 17

Cannot exctrete bile into the duodenum

Question 18

How can enterohepatic circulation prolong lipid life in the body

Answer 18

By recycling lipids and bile between the ileum and liver