Lecture 6 (Part 2) Flashcards

1
Q

Blood supply to the brain is about…

A

750ml/min or 50ml of blood/min/100g (steady supply)

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2
Q

Blood-brain barrier (BBB):

A

prevents the access of lipid soluble molecules to the brain, thus it essentially relies on glucose for its energy supply

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3
Q

why does very little anaerobic metabolism take place in the brain

A

Glucose is mostly oxidized in the brain with just a small portion being released as lactate

therefore, the brain has relatively high rates of O2 consumption and CO2 production

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4
Q

Under prolonged starvation, the brain adapts to use what as energy

A

ketones (fat oxidation)

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5
Q

How does the brain use ketone bodies as an energy substrate during prolonged fasting or starvation

A

Fat that comes from adipose tissue enters the blood and goes to the liver which breaks it down, and some of it is converted into ketones

Ketones are a smaller molecule that can pass through the BBB and serve as the energy source

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